Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis [PDF]
Cell & BioscienceBackground Trichinosis is one of the most widespread parasitic infections worldwide. Trichinella spiralis not only infects humans but can also utilize wild anddomestic animals as hosts. The serine protease inhibitors secreted by Trichinella spiralis play
Ruixue Li, Bing Zhang, Chen Chen
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Serpins in rice: protein sequence analysis, phylogeny and gene expression during development
BMC Genomics, 2012 Background Most members of the serpin family of proteins are potent, irreversible inhibitors of specific serine or cysteine proteinases. Inhibitory serpins are distinguished from members of other families of proteinase inhibitors by their metastable ...
Francis Sheila E +4 more
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Host cell and viral protease targets of human SERPINs identified by in silico docking [PDF]
The EMBO JournalSerine protease inhibitors (SERPINs) are involved in various physiological processes and diseases, such as inflammation, cancer metastasis, and neurodegeneration.
Joaquin Rodriguez Galvan +9 more
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PLoS Neglected Tropical Diseases, 2020 Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological processes, including digestion, coagulation, inflammation and immune responses. The presence of serpins in Fasciola hepatica excretory-secretory products indicates
Carolina De Marco Verissimo +6 more
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Investigation of a Serine Protease Inhibitor Active in the Infectious Stage of the Human Liver Fluke Opisthorchis viverrini [PDF]
PathogensSerine protease inhibitors (serpins) participate in the regulation of inflammation, blood coagulation, and complement activation in humans. This research aimed to identify and characterize such inhibitors of the human liver fluke Opisthorchis viverrini ...
Rosnanee Salang +3 more
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Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum-infected macrophages [PDF]
mBioSerine protease inhibitors (serpins) constitute the largest family of protease inhibitors expressed in humans, but their role in infection remains largely unexplored.
Esther Nobs +5 more
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Serine protease inhibitors and human wellbeing interplay: new insights for old friends [PDF]
PeerJ, 2019 Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets.
Héla Mkaouar +8 more
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Serpins in cartilage and osteoarthritis: what do we know?
Biochemical Society Transactions, 2021 Serpins (serine proteinase inhibitors) are an ancient superfamily of structurally similar proteins, the majority of which use an elegant suicide inhibition mechanism to target serine proteinases. Despite likely evolving from a single common ancestor, the
David J. Wilkinson
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Serpin functions in host-pathogen interactions [PDF]
PeerJ, 2018 Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors.
Jialing Bao +5 more
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Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders
Frontiers in Cardiovascular Medicine, 2021 Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential
Elsa P. Bianchini +4 more
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