Results 71 to 80 of about 45,777 (283)

The severe combined immunodeficiency (scid) mouse. A laboratory model for the analysis of Lyme arthritis and carditis

Journal of Experimental Medicine, 1989
We report that the spirochete B. burgdorferi induces progressive polyarthritis and carditis in mice with severe combined immunodeficiency syndrome (scid) but not in normal C.B-17 mice.
Ulrich E. Schaible, M. Kramer, Crisan Museteanu, G. Zimmer, Horst Mossmann, M. Simon   +5 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Recent advances in understanding RAG deficiencies [version 1; referees: 2 approved]

F1000Research, 2019
Recombination-activating genes (RAG)1 and RAG2 initiate the molecular processes that lead to lymphocyte receptor formation through VDJ recombination.
Andrew Gennery
doaj   +1 more source

Newborn Screening for SCID and Other Severe Primary Immunodeficiency in the Polish-German Transborder Area: Experience From the First 14 Months of Collaboration

Frontiers in Immunology, 2020
In 2017, in the Polish-German transborder area of West Pomerania, Mecklenburg-Western Pomerania, and Brandenburg, in collaboration with two centers in Warsaw, a partnership in the field of newborn screening (NBS) for severe primary immunodeficiency ...
Maria Giżewska, Maria Giżewska, Katarzyna Durda, Theresa Winter, Theresa Winter, Iwona Ostrowska, Mariusz Ołtarzewski, Jeannette Klein, Oliver Blankenstein, Hanna Romanowska, Hanna Romanowska, Elżbieta Krzywińska-Zdeb, Elżbieta Krzywińska-Zdeb, Michał Filip Patalan, Michał Filip Patalan, Elżbieta Bartkowiak, Natalia Szczerba, Stefan Seiberling, Bożena Birkenfeld, Bożena Birkenfeld, Matthias Nauck, Matthias Nauck, Horst von Bernuth, Horst von Bernuth, Horst von Bernuth, Christian Meisel, Christian Meisel, Ewa Anna Bernatowska, Mieczysław Walczak, Mieczysław Walczak, Małgorzata Pac   +30 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Long-term neurocognitive function of pediatric patients with severe combined immune deficiency (SCID): pre- and post-hematopoietic stem cell transplant (HSCT). [PDF]

, 2009
BACKGROUND:Hematopoietic stem cell transplantation (HSCT) is the only cure for patients with severe combined immunodeficiency (SCID). The purpose of this study was to evaluate long-term neurodevelopment of patients with SCID following myeloablative ...
Azen, Colleen, Epport, Karen, Kohn, Donald B, Lin, Malinda, Parkman, Robertson, Shah, Ami J   +5 more
core  

Unbalanced Immune System: Immunodeficiencies and Autoimmunity [PDF]

, 2016
Increased risk of developing autoimmune manifestations has been identified in different primary immunodeficiencies (PIDs). In such conditions, autoimmunity and immune deficiency represent intertwined phenomena that reflect inadequate immune function ...
CAPALBO, DONATELLA, CIRILLO, EMILIA, D'ASSANTE, ROBERTA, De Cataldis, M, Di Giacomo, C, GALLO, VERA, Gaudino, G, GIARDINO, GIULIANA, Lorello, P, PALAMARO, LOREDANA, PIGNATA, CLAUDIO, PRENCIPE, MARIA ROSARIA, ROMANO, ROBERTA   +12 more
core   +2 more sources

723 STEM CELL DEFECTS IN SEVERE COMBINED IMMUNODEFICIENCY (SCID) [PDF]

Pediatric Research, 1978
Fractionated bone marrow cells from normal volunteers can regularly be induced to bear the human T-lymphocyte antigen (HTLA) marker to form E-rosettes and respond to concanavalin A (Con A) following coculture with normal thymic epithelial mono-layers (TEM) or supernatants (SUP). T-cell differentiation done in this way on marrow cells of 5 patients with
R Pahwa, S Pahwa, R J O'Reilly, R A Good
openaire   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

CsA can induce DNA double-strand breaks: implications for BMT regimens particularly for individuals with defective DNA repair [PDF]

, 2008
Several human disorders mutated in core components of the major DNA double-strand break (DSB) repair pathway, non-homologous end joining (NHEJ), have been described.
A Enders, A Gennery, A O'Marcaigh, B Gruhn, C Ahlers, C Couedel, D Buck, D Moshous, DB Yarosh, E Riballo, EP Rogakou, EP Rogakou, F Tremblay, HJ Deeg, HJ Deeg, HJ Kolb, IB Resnick, J Aschan, JF Buell, KW Caldecott, KW Caldecott, KW Caldecott, M Herman, M Herman, M Lobrich, M O'Driscoll, M O'Driscoll, M O'Driscoll, M Takata, M van der Burg, N Duncan, N Kobayashi, NJ Reynolds, O Fernandez-Capetillo, O Fernandez-Capetillo, P A Jeggo, P Ahnesorg, P Karran, P O'Donovan, RH Buckley, S Franco, S Franco, T Lindahl, T Ruutu, U Grawunder   +44 more
core   +1 more source