Results 111 to 120 of about 3,150,561 (392)

The pathophysiology of severe falciparum malaria

Parasitology Today, 1986
By the end of the 1940s, the clinical and pathological features of severe falciparum malaria had been well described by military physicians and pathologists working in theatres of war where the disease was endemic. From that time serious efforts were made to discover the pathophysiology of the severe manifestations of malaria because an understanding ...
Phillips, R, Warrell, D
openaire   +3 more sources

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

Serum Angiopoietin-1 and -2 and VEGF are associated with severe disease in vivax malaria

Journal of Vector Borne Diseases, 2020
Background & objectives: Malaria continues to be a significant public health problem in tropical countries including India; however, there are limited tools to predict occurrence of severe disease due to malaria.
Srinivas H Gowda, Hiren Anghan, Hridesh Mishra, Kunzang Chosdol, Manasvini Bhatt, Vinod Kumar, Piyush Ranjan, Praveen Aggarwal, Naveet Wig, Manish Soneja   +9 more
doaj   +1 more source

Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia [PDF]

, 2015
This deposit is composed by the main article, and it hasn't any supplementary materials associated.Haemoglobin S (HbS) is the gene known to confer the strongest advantage against malaria morbidity and mortality.
Costa, João, Coutinho, António, do Sambo, Maria Rosário, Lardoeyt, Roberto, Penha-Gonçalves, Carlos, Trovoada, Maria Jesus   +5 more
core   +2 more sources

Clinical and laboratory predictors of death in African children with features of severe malaria: a systematic review and meta-analysis

BMC Medicine, 2017
BackgroundThe criteria for defining severe malaria have evolved over the last 20 years. We aimed to assess the strength of association of death with features currently characterizing severe malaria through a systematic review and meta-analysis ...
Paulina Sypniewska, J. Duda, I. Locatelli, C. R. Althaus, F. Althaus, B. Genton   +5 more
semanticscholar   +1 more source

The Management of Patients with Severe Malaria

The American Journal of Tropical Medicine and Hygiene, 2007
Severe malaria is a global problem, claiming at least 1 million lives annually. Few adequately powered clinical studies have been directed at improving the management of severe malaria over the years, but this situation is slowly changing. The antimalarial treatment of severe disease is being transformed by the development and deployment of the water ...
Day, N, Dondorp, A
openaire   +4 more sources

Possibilities for Climate Change Adaptation Investments in Ghana: Exploring Private Sector Concerns and Perceptions About Policy Incentives

Business Strategy and the Environment, EarlyView.
ABSTRACT Policy incentives can significantly boost private sector investment in climate change adaptation, especially in developing countries. Leveraging private sector resources, including human capital, financial assets, and technological innovations, is crucial for enhancing adaptation efforts.
Jane Osei, Albert Ahenkan, Samuel Weniga Anuga   +2 more
wiley   +1 more source

Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study.

American Journal of Tropical Medicine and Hygiene, 2017
We studied associations between delayed care seeking, demographic, socioeconomic, and geographic factors and likelihood of severe malaria in Ugandan children. The study was based at Jinja Hospital, Uganda.
A. Mpimbaza, G. Ndeezi, Anne Ruhweza Katahoire, P. Rosenthal, C. Karamagi   +4 more
semanticscholar   +1 more source

Pathophysiology of severe malaria in children

Acta Tropica, 2004
Over the past decade there has been a growing recognition that the rationalization of severe malaria in children into the two major syndromes of cerebral malaria and severe malaria anaemia is much too simplistic. Indeed, it has become apparent that death from severe malaria may arise from a wider spectrum of pathophysiological disorders with many ...
Maitland, K, Marsh, K
openaire   +3 more sources

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source