Results 101 to 110 of about 350 (116)
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Fish & Shellfish Immunology
IgNAR exhibits significant promise in the fields of cancer and anti-virus biotherapies. Notably, the variable regions of IgNAR (VNAR) possess comparable antigen binding affinity with much smaller molecular weight (∼12 kDa) compared to IgNAR. Antigen specific VNAR screening is a changeling work, which limits its application in medicine and therapy ...
Bo Zhong +10 more
openaire +2 more sources
IgNAR exhibits significant promise in the fields of cancer and anti-virus biotherapies. Notably, the variable regions of IgNAR (VNAR) possess comparable antigen binding affinity with much smaller molecular weight (∼12 kDa) compared to IgNAR. Antigen specific VNAR screening is a changeling work, which limits its application in medicine and therapy ...
Bo Zhong +10 more
openaire +2 more sources
International Journal of Biological Macromolecules
The Shark-derived immunoglobulin new antigen receptors (IgNARs) have gained increasing attention for their high solubility, exceptional thermal stability, and intricate sequence variation. In this study, we immunized whitespotted bamboo shark (Chiloscyllium plagiosum) to create phage display library of variable domains of IgNAR (VNARs) for screening ...
Weijie, Li +10 more
openaire +2 more sources
The Shark-derived immunoglobulin new antigen receptors (IgNARs) have gained increasing attention for their high solubility, exceptional thermal stability, and intricate sequence variation. In this study, we immunized whitespotted bamboo shark (Chiloscyllium plagiosum) to create phage display library of variable domains of IgNAR (VNARs) for screening ...
Weijie, Li +10 more
openaire +2 more sources
2015
The aim of the work presented herein was the generation of high-affinity shark vNAR domains targeting different disease related antigens. For this, the natural IgNAR V domain repertoire of the bamboo shark (Chiloscyllium plagiosum) was analyzed and in analogy to these findings, a semi-synthetic complementarity determining region 3 (CDR3)-randomized ...
openaire +1 more source
The aim of the work presented herein was the generation of high-affinity shark vNAR domains targeting different disease related antigens. For this, the natural IgNAR V domain repertoire of the bamboo shark (Chiloscyllium plagiosum) was analyzed and in analogy to these findings, a semi-synthetic complementarity determining region 3 (CDR3)-randomized ...
openaire +1 more source
Generation of VNAR Libraries from Immunized Sharks and Selection of Target-Specific Clones
Methods in Molecular Biology, 2022Helen Dooley
exaly
High affinity binding proteins derived from shark vNAR domains by stepwise affinity maturation
Journal of Biotechnology, 2014Martin Empting +2 more
exaly
Cytoplasmic and periplasmic expression of recombinant shark VNAR antibody in Escherichia coli
Preparative Biochemistry and Biotechnology, 2019James S McCarthy +2 more
exaly