Results 101 to 107 of about 335 (107)

The shark strikes twice: Generation of Mono- and Bispecific High-Affinity vNAR Antibody Domains via Step-Wise Affinity Maturation

2015
The aim of the work presented herein was the generation of high-affinity shark vNAR domains targeting different disease related antigens. For this, the natural IgNAR V domain repertoire of the bamboo shark (Chiloscyllium plagiosum) was analyzed and in analogy to these findings, a semi-synthetic complementarity determining region 3 (CDR3)-randomized ...
openaire   +1 more source

Ancient species offers contemporary therapeutics: an update on shark VNAR single domain antibody sequences, phage libraries and potential clinical applications

Antibody Therapeutics, 2020
Jessica Hong, Mitchell Ho, Ho Mitchell   +2 more
exaly  

Human TNF cytokine neutralization with a vNAR fromHeterodontus franciscishark: A potential therapeutic use

MAbs, 2013
Tanya A Camacho-Villegas, Edna Sánchez-Castrejón   +1 more
exaly  

Cytoplasmic and periplasmic expression of recombinant shark VNAR antibody in Escherichia coli

Preparative Biochemistry and Biotechnology, 2019
Katja Fischer, Qin Cheng, James S Mccarthy   +2 more
exaly  

KRM1 Targeting Shark VNARs Confer Broad Protection Against Enterovirus Infection

openaire   +1 more source

Synthesis of Shark VNAR Antibody Labelled Gold Nanoparticles for Potential Plasmodium Falciparum, Malaria Diagnosis Kit Development

Dhenmolly Arumugam, Nor Dyana Zakaria, Boon Hui Kok, Khairunisak Abdul Razak, Chiuan Yee Leow, Chiuan Herng Leow   +5 more
openaire   +1 more source

Swimming with sharks: expression, purification, and characterization of variable new antigen receptor (VNAR) mutant variants

openaire   +1 more source