Results 81 to 90 of about 350 (116)

Marine Natural Products as Anticancer Agents 3.0. [PDF]

Mar Drugs
Alves C, Diederich M.
europepmc   +1 more source

vNARs as Neutralizing Intracellular Therapeutic Agents: Glioblastoma as a Target. [PDF]

Antibodies (Basel)
Manzanares-Guzmán A, Lugo-Fabres PH, Camacho-Villegas TA.   +2 more
europepmc   +1 more source

Nanobody fusion enhances production of difficult-to-produce secretory proteins. [PDF]

J Biol Chem
Yan R, Zhang Y, Zhang H, Ma J.
europepmc   +1 more source

Broad Neutralizing Antibodies Against SARS-CoV-2: Current Progress and Engineering Strategies. [PDF]

Viruses
Jia T, Huang Z, Xia N, Yuan Q.
europepmc   +1 more source

Insights into the recognition mechanism of shark-derived single-domain antibodies with high affinity and specificity targeting fluoroquinolones. [PDF]

Mar Life Sci Technol
Liu C, Li G, Chen Y, Lin H, Cao L, Wang K, Wang X, Flajnik MF, Sui J.   +8 more
europepmc   +1 more source

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Construction of Semisynthetic Shark vNAR Yeast Surface Display Antibody Libraries

Methods in Molecular Biology, 2023
The adaptive immune system of sharks comprises a unique heavy chain-only antibody isotype, termed immunoglobulin new antigen receptor (IgNAR), in which antigen binding is mediated by a single variable domain, referred to as vNAR. In recent years, efforts were made to harness these domains for biomedical and biotechnological applications particularly ...
Stefan Zielonka, Harald Kolmar, Doreen Könning   +2 more
exaly   +3 more sources

Exploring shark VNAR antibody against infectious diseases using phage display technology

Fish and Shellfish Immunology, 2023
Antibody with high affinity and specificity to antigen has widely used as a tool to combat various diseases. The variable domain of immunoglobulin new antigen receptor (VNAR) naturally found in shark contains autonomous function as single-domain antibody.
Chiuan Yee Leow, Chiuan Herng Leow, Hui Ting Lim   +2 more
exaly   +3 more sources

Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody

International Journal of Biological Macromolecules, 2020
Conventional monoclonal antibodies (mAbs) have been widely used in research and diagnostic applications due to their high affinity and specificity. However, multiple limitations, such as large size, complex structure and sensitivity to extreme ambient temperature potentially weaken the performance of mAbs in certain applications.
Chiuan Yee Leow, ABA Majeed, Chiuan Herng Leow   +2 more
exaly   +3 more sources