Results 81 to 90 of about 335 (107)

Nanobody fusion enhances production of difficult-to-produce secretory proteins. [PDF]

J Biol Chem
Yan R, Zhang Y, Zhang H, Ma J.
europepmc   +1 more source

Insights into the recognition mechanism of shark-derived single-domain antibodies with high affinity and specificity targeting fluoroquinolones. [PDF]

Mar Life Sci Technol
Liu C, Li G, Chen Y, Lin H, Cao L, Wang K, Wang X, Flajnik MF, Sui J.   +8 more
europepmc   +1 more source

CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization. [PDF]

Cell Res
Qiu S, Chen J, Wu T, Li L, Wang G, Wu H, Song X, Liu X, Wang H.   +8 more
europepmc   +1 more source

Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies. [PDF]

Genes Dis
Juma SN, Liao J, Huang Y, Vlashi R, Wang Q, Wu B, Wang D, Wu M, Chen G.   +8 more
europepmc   +1 more source

Production of Clinical-Grade SARS-CoV-2 Spike Ferritin Nanoparticle Protein Immunogen by Transient Transfection. [PDF]

Vaccines (Basel)
Hajduczki A, Chang WC, De La Barrera R, Wood JF, Chen WH, Martinez EJ, Jensen JL, Sankhala RS, Smith C, Anderson A, Morrison EB, Peterson CE, Rees PA, Soman S, Kuklis C, Ahmed A, King J, Nasar F, Corbitt C, Choe M, Thomas PV, Zemil M, Wieczorek L, Polonis VR, Dooley HM, Mascola JR, de Val N, Matyas GR, Rao M, Gromowski GD, Modjarrad K, Vasan S, Froude JW, Michael NL, Joyce MG, Zarling S.   +35 more
europepmc   +1 more source

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Construction of Semisynthetic Shark vNAR Yeast Surface Display Antibody Libraries

Methods in Molecular Biology, 2023
The adaptive immune system of sharks comprises a unique heavy chain-only antibody isotype, termed immunoglobulin new antigen receptor (IgNAR), in which antigen binding is mediated by a single variable domain, referred to as vNAR. In recent years, efforts were made to harness these domains for biomedical and biotechnological applications particularly ...
Harald Kolmar, Julius Grzeschik, Doreen Könning   +2 more
exaly   +3 more sources

Exploring shark VNAR antibody against infectious diseases using phage display technology

Fish and Shellfish Immunology, 2023
Antibody with high affinity and specificity to antigen has widely used as a tool to combat various diseases. The variable domain of immunoglobulin new antigen receptor (VNAR) naturally found in shark contains autonomous function as single-domain antibody.
Hui Ting Lim, Boon Hui Kok, Chiuan Yee Leow   +2 more
exaly   +3 more sources

Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody

International Journal of Biological Macromolecules, 2020
Conventional monoclonal antibodies (mAbs) have been widely used in research and diagnostic applications due to their high affinity and specificity. However, multiple limitations, such as large size, complex structure and sensitivity to extreme ambient temperature potentially weaken the performance of mAbs in certain applications.
Chiuan Yee Leow, Abu Bakar Abdul Majeed, Chiuan Herng Leow   +2 more
exaly   +3 more sources

Shark Attack: High affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation

Journal of Biotechnology, 2014
A novel method for stepwise in vitro affinity maturation of antigen-specific shark vNAR domains is described that exclusively relies on semi-synthetic repertoires derived from non-immunized sharks. Target-specific molecules were selected from a CDR3-randomized bamboo shark (Chiloscyllium plagiosum) vNAR library using yeast surface display as platform ...
Stefan Zielonka, Andreas Christmann, Martin Empting   +2 more
exaly   +3 more sources

Shark VNAR phage display libraries: An alternative source for therapeutic and diagnostic recombinant antibody fragments

Fish & Shellfish Immunology, 2023
The development of recombinant antibody fragments as promising alternatives to full-length immunoglobulins offers vast opportunities for biomedicine. Antibody fragments have important advantages compared with conventional monoclonal antibodies that make them attractive for the biotech industry: superior stability and solubility, reduced immunogenicity,
Karen, Manoutcharian, Goar, Gevorkian
openaire   +2 more sources