Results 71 to 80 of about 564 (139)
Control of malaria by bio-therapeutics and drug delivery systems [PDF]
, 2017 Malaria is a ubiquitous disease that can affect more than 40% of the world’s population who live with some risk of contracting this disease. The World Health Organization (WHO) has recently highlighted the high spread of this disease in Sub-Saharan ...
Al-Qaraghuli, Mohammed M +3 more
core +2 more sources
PharmaceuticalsBackground/Objectives: Precise intracellular delivery of chemotherapeutics remains a major challenge in HER2-positive breast cancer, where intratumoral heterogeneity and limited tissue penetration constrain efficacy.
Andrea C. Alfonseca-Ladrón de Guevara +5 more
doaj +1 more source
Single Domain Antibodies as New Biomarker Detectors
Diagnostics, 2017 Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow +5 more
doaj +1 more source
Efficient Construction and Effective Screening of Synthetic Domain Antibody Libraries
Methods and Protocols, 2019 Phage display is a powerful technique for drug discovery in biomedical research in particular for antibody libraries. But, several technical challenges are associated with the selection process.
Arghavan Solemani Zadeh +4 more
doaj +1 more source
Expresión recombinante de un dominio vNAR anti-EGFRvIII Epidermal Growth Factor Receptor presente en células tumorales, PAP realizado en el CIATEJ [PDF]
, 2023 Este proyecto, denominado "Expresión recombinante de un dominio vNAR anti-EGFRvIII (Epidermal Growth Factor Receptor) presente en células tumorales", tiene como propósito general extraer y aislar una proteína específica (vNAR R426) con el fin de ...
Urzúa-TorresSeptién, Andrés
core
Enhancing Stability of Camelid and Shark Single Domain Antibodies: An Overview
Frontiers in Immunology, 2017 Single domain antibodies (sdAbs) are gaining a reputation as superior recognition elements as they combine the advantages of the specificity and affinity found in conventional antibodies with high stability and solubility.
Ellen R. Goldman +3 more
doaj +1 more source
ファージディスプレイ法を利用したドチザメ Triakis scyllium 免疫グロブリンの性状解析 [PDF]
, 2021 東京海洋大学修士(海洋科学)東京海洋大学修士学位論文 2020年度(2021年3月) 海洋生命資源科学 修士 第3444号指導教員: 近藤秀裕全文公表年月日: 2023-07 ...
4481 +2 more
core
Advances in the Production and Batch Reformatting of Phage Antibody Libraries [PDF]
, 2019 Phage display antibody libraries have proven an invaluable resource for the isolation of diagnostic and potentially therapeutic antibodies, the latter usually being antibody fragments converted into IgG formats.
Gough, Kevin C. +3 more
core +2 more sources
Switching Aurora-A kinase on and off at an allosteric site [PDF]
, 2017 Protein kinases are central players in the regulation of cell cycle and signalling pathways. Their catalytic activities are strictly regulated through post-translational modifications and protein–protein interactions that control switching between ...
Barr +40 more
core +1 more source
Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]
In addition to antibodies with the classical composition of heavy and light chains, the adaptive immune repertoire of sharks also includes a heavy-chain only isotype, where antigen binding is mediated exclusively by a small and highly stable domain ...
Barelle, Caroline J. +5 more
core +1 more source