Results 51 to 60 of about 350 (116)

Ueg Week 2020 Poster Presentations

, 2020
United European Gastroenterology Journal, Volume 8, Issue S8, Page 144-887, October 2020.
wiley   +1 more source

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Frontiers in Immunology, 2019
Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases.
Obinna C. Ubah, John Steven, Andrew J. Porter, Andrew J. Porter, Caroline J. Barelle   +4 more
doaj   +1 more source

Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharks [PDF]

Antibody Therapeutics, 2018
ABSTRACT Background Shark new antigen receptor variable domain (VNAR) antibodies can bind restricted epitopes that may be inaccessible to conventional antibodies. Methods Here, we developed a library construction method based on ...
Feng, Mingqian, Bian, Hejiao, Wu, Xiaolin, Fu, Tianyun, Fu, Ying, Hong, Jessica, Fleming, Bryan D, Flajnik, Martin F, Ho, Mitchell   +8 more
openaire   +2 more sources

Single Domain Antibodies as New Biomarker Detectors

Diagnostics, 2017
Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow, Katja Fischer, Chiuan Yee Leow, Qin Cheng, Candy Chuah, James McCarthy   +5 more
doaj   +1 more source

Efficient Construction and Effective Screening of Synthetic Domain Antibody Libraries

Methods and Protocols, 2019
Phage display is a powerful technique for drug discovery in biomedical research in particular for antibody libraries. But, several technical challenges are associated with the selection process.
Arghavan Solemani Zadeh, Alissa Grässer, Heiko Dinter, Maximilian Hermes, Katharina Schindowski   +4 more
doaj   +1 more source

Enhancing Stability of Camelid and Shark Single Domain Antibodies: An Overview

Frontiers in Immunology, 2017
Single domain antibodies (sdAbs) are gaining a reputation as superior recognition elements as they combine the advantages of the specificity and affinity found in conventional antibodies with high stability and solubility.
Ellen R. Goldman, Jinny L. Liu, Dan Zabetakis, George P. Anderson   +3 more
doaj   +1 more source

Identification of nurse shark V_NAR single-domain antibodies targeting the spike S2 subunit of SARS-CoV-2. [PDF]

FASEB J, 2023
Buffington J, Duan Z, Kwon HJ, Hong J, Li D, Feng M, Xie H, Ho M.   +7 more
europepmc   +1 more source

MOESM1 of Isolation and characterization of malaria PfHRP2 specific VNAR antibody fragments from immunized shark phage display library

, 2018
Additional file 1. PCR amplification of randomly selected plaques from the VNAR domains primary library using T7SelectUP (For) and T7SelectDOWN (Rev) sequencing primers. Lane M represents 100 bp ladder; lane 1â 20 represents insert of single plaque; lane â ve represents negative control (PCR product with no cDNA template).
Leow, Chiuan, Fischer, Katja, Braet, Katleen, Cheng, Qin, McCarthy, James   +4 more
openaire   +1 more source

MOESM2 of Isolation and characterization of malaria PfHRP2 specific VNAR antibody fragments from immunized shark phage display library

, 2018
Additional file 2. Deduced amino acid sequences in hypervariable regions of VNAR clones targeting to three malaria biomarkers. The non-canonical cysteine residue is highlighted in red colour. This table also indicates the length of CDR3, number of cysteine residue, and type of IgNAR family for each clone.
Leow, Chiuan, Fischer, Katja, Braet, Katleen, Cheng, Qin, McCarthy, James   +4 more
openaire   +1 more source

Humanized shark variable new antigen receptors (VNARs) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source