Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]
, 2014 Peer reviewedPublisher ...
Barelle, Caroline +5 more
core +1 more source
Analysis of the binding loops configuration and surface adaptation of different crystallized single‐domain antibodies in response to various antigens [PDF]
, 2017 Monoclonal antibodies have revolutionized the biomedical field through their ubiquitous utilization in different diagnostics and therapeutic applications.
Al Qaraghuli +93 more
core +1 more source
Human TNF cytokine neutralization with a vNAR fromHeterodontus franciscishark: A potential therapeutic use [PDF]
mAbs, 2013 The therapeutic use of single domain antibodies (sdAbs) is a promising new approach because these small antibodies maintain antigen recognition and neutralization capacity, have thermal and chemical stability and have good solubility. In this study, using phage display technology, we isolated a variable domain of a IgNAR (vNAR) from a Heterodontus ...
Tanya, Camacho-Villegas +4 more
openaire +2 more sources
Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand [PDF]
, 2019 Acknowledgments Supported by an unrestricted departmental grant from Research to Prevent Blindness (New York, NY), NEI K08EY023998 (KLP), P30-EY001730 (RVG; Bethesda, MD), by a grant from Elasmogen Limited (RVG), and with support from the Mark J.
Barelle, Caroline J. +7 more
core +1 more source
Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018 Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement with CD28 costimulation. The interaction of ICOS with its sole ligand, the inducible T cell costimulatory ligand (ICOSL; also known as B7‐related protein‐1 ...
Ronan O’Dwyer +11 more
wiley +1 more source
The Development of Single Domain Antibodies for Diagnostic and Therapeutic Applications [PDF]
, 2018 Monoclonal antibodies have become increasingly accepted as diagnostics and therapeutics for various human diseases due to their high affinity and specificity.
Cheng, Qin +3 more
core +2 more sources
Escherichia coli surface display for the selection of nanobodies
Microbial Biotechnology, Volume 10, Issue 6, Page 1468-1484, November 2017., 2017 Libraries of VHH genes encoding nanobodies have been traditionally cloned in phage display or yeast display systems. This review briefly describes these conventional approaches and focuses on the distinct properties of an E. coli display system developed in our laboratory, which combines the benefits of both phage display and yeast display systems ...
Valencio Salema, Luis Ángel Fernández
wiley +1 more source
CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration [PDF]
, 2023 Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood–brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy.
Coker, Shu-Fen +11 more
core +2 more sources
Bamboo Shark as a Small Animal Model for Single Domain Antibody Production
Frontiers in Bioengineering and Biotechnology, 2021 The development of shark single domain antibodies (sdAbs) is hindered by the high cost and tediousness of large-sized shark farming. Here, we demonstrated white-spotted bamboo sharks (Chiloscyllium plagiosum) being cultivated commercially as a promising ...
Likun Wei +24 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system.
Monica L. Fernández-Quintero +3 more
doaj +1 more source