Results 41 to 50 of about 335 (107)

Anti‐ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen‐Induced Mouse Model of Rheumatoid Arthritis

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement with CD28 costimulation. The interaction of ICOS with its sole ligand, the inducible T cell costimulatory ligand (ICOSL; also known as B7‐related protein‐1 ...
Ronan O’Dwyer, Marina Kovaleva, Jiquan Zhang, John Steven, Emma Cummins, Deborah Luxenberg, Alfredo Darmanin-Sheehan, Miguel F. Carvalho, Matthew Whitters, Kenneth Saunders, Caroline J. Barelle, Ilaria Roato   +11 more
wiley   +1 more source

Bamboo Shark as a Small Animal Model for Single Domain Antibody Production

Frontiers in Bioengineering and Biotechnology, 2021
The development of shark single domain antibodies (sdAbs) is hindered by the high cost and tediousness of large-sized shark farming. Here, we demonstrated white-spotted bamboo sharks (Chiloscyllium plagiosum) being cultivated commercially as a promising ...
Likun Wei, Meiniang Wang, Meiniang Wang, Haitao Xiang, Haitao Xiang, Haitao Xiang, Yuan Jiang, Jinhua Gong, Dan Su, M. A. R. Al Azad, Hongming Dong, Hongming Dong, Hongming Dong, Limin Feng, Jiajun Wu, Leo Lai Chan, Leo Lai Chan, Naibo Yang, Naibo Yang, Naibo Yang, Jiahai Shi, Jiahai Shi, Jiahai Shi, Jiahai Shi, Jiahai Shi   +24 more
doaj   +1 more source

Escherichia coli surface display for the selection of nanobodies

Microbial Biotechnology, Volume 10, Issue 6, Page 1468-1484, November 2017., 2017
Libraries of VHH genes encoding nanobodies have been traditionally cloned in phage display or yeast display systems. This review briefly describes these conventional approaches and focuses on the distinct properties of an E. coli display system developed in our laboratory, which combines the benefits of both phage display and yeast display systems ...
Valencio Salema, Luis Ángel Fernández
wiley   +1 more source

Shark Antibody Variable Domains Rigidify Upon Affinity Maturation—Understanding the Potential of Shark Immunoglobulins as Therapeutics

Frontiers in Molecular Biosciences, 2021
Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system.
Monica L. Fernández-Quintero, Clarissa A. Seidler, Patrick K. Quoika, Klaus R. Liedl   +3 more
doaj   +1 more source

Specific Targeting of Lymphoma Cells Using Semisynthetic Anti-Idiotype Shark Antibodies

Frontiers in Immunology, 2020
The B-cell receptor (BCR) is a key player of the adaptive immune system. It is a unique part of immunoglobulin (Ig) molecules expressed on the surface of B cells. In case of many B-cell lymphomas, the tumor cells express a tumor-specific and functionally
Arturo Macarrón Palacios, Julius Grzeschik, Lukas Deweid, Simon Krah, Stefan Zielonka, Thies Rösner, Matthias Peipp, Thomas Valerius, Harald Kolmar   +8 more
doaj   +1 more source

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development

Frontiers in Immunology, 2017
The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics.
Obinna C. Ubah, John Steven, Marina Kovaleva, Laura Ferguson, Charlotte Barelle, Andrew J. R. Porter, Andrew J. R. Porter, Caroline J. Barelle   +7 more
doaj   +1 more source

Single domain antibody: Development and application in biotechnology and biopharma

Immunological Reviews, Volume 328, Issue 1, Page 98-112, November 2024.
Summary Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb).
Ting Yu, Fang Zheng, Wenbo He, Serge Muyldermans, Yurong Wen   +4 more
wiley   +1 more source

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins

Antibodies, 2015
At 420 million years, the variable domain of New Antigen Receptors or VNARs are undoubtedly the oldest (and smallest) antigen binding single domains identified in the vertebrate kingdom.
Caroline Barelle, Andy Porter
doaj   +1 more source

Ueg Week 2020 Poster Presentations

, 2020
United European Gastroenterology Journal, Volume 8, Issue S8, Page 144-887, October 2020.
wiley   +1 more source

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Frontiers in Immunology, 2019
Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases.
Obinna C. Ubah, John Steven, Andrew J. Porter, Andrew J. Porter, Caroline J. Barelle   +4 more
doaj   +1 more source