Results 31 to 40 of about 350 (116)
Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical Applications
Cells, 2021 Shark is a cartilaginous fish that produces new antigen receptor (IgNAR) antibodies. This antibody is identified with a similar human heavy chain but dissimilar sequences.
Salma Nassor Juma +6 more
doaj +1 more source
Marine Drugs, 2022 Tumor necrosis factor α (TNFα), an important clinical testing factor and drug target, can trigger serious autoimmune diseases and inflammation. Thus, the TNFα antibodies have great potential application in diagnostics and therapy fields.
Linfei Zhao +5 more
doaj +1 more source
Ancient species offers contemporary therapeutics: an update on shark V<sub>NAR</sub> single domain antibody sequences, phage libraries and potential clinical applications. [PDF]
Antib Ther, 2020 ABSTRACTThe antigen binding variable domain (VNAR) of the shark immunoglobulin new antigen receptor (IgNAR) evolved approximately 500 million years ago and it is one of the smallest antibody fragments in the animal kingdom with sizes of 12–15 kDa.
English H, Hong J, Ho M.
europepmc +4 more sources
Marine-derived microbes and molecules for drug discovery
Inflammation and Regeneration, 2022 Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many islands and is surrounded by seas, straits, gulfs, bays, and coves, giving it the second longest coastline ...
Yoshimasa Tanaka +8 more
doaj +1 more source
Shark-derived single-domain antibodies for the detection of decapod iridescent virus 1
Aquaculture Reports, 2023 Decapod iridescent virus 1 (DIV1) has emerged as a novel threat to shrimp farming. The development of a rapid, convenient, and accurate method for diagnosing DIV1 is urgently needed, serving as a key factor in the reduction of the risk of viral outbreaks.
Jinlin Chen +6 more
doaj +1 more source
Frontiers in Marine Science, 2023 Elasmobranchs are crucial for comparative studies of evolution, as they belong to the most ancient vertebrate lineages that survived numerous extinction events and persist until today.
Jianqing Wen +14 more
doaj +1 more source
Nature Communications, 2021 Shark antibodies (Variable New Antigen Receptors, VNARs) are the smallest naturally occurring antibody fragments. Here, the authors screen a VNAR phage display library against the SARS-CoV2 receptor binding domain (RBD) and identify VNARs that neutralize
Obinna C. Ubah +20 more
doaj +1 more source
Brain delivery of biologics using a cross‐species reactive transferrin receptor 1 VNAR shuttle
The FASEB Journal, Volume 34, Issue 10, Page 13272-13283, October 2020., 2020 Abstract Transferrin receptor 1 (TfR1) mediated transcytosis is an attractive strategy to enhance brain uptake of protein drugs, but translation remains a challenge. Here, a single domain shark antibody VNAR fragment (TXB2) with similar affinity to murine and human TfR1 was used to shuttle protein cargo into the brain. TXB2 was fused to a human IgG1 Fc
Dag Sehlin +6 more
wiley +1 more source
Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD Protein
International Journal of Molecular Sciences, 2022 The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the major target for antibody therapeutics. Shark-derived variable domains of new antigen receptors (VNARs) are the smallest antibody fragments with flexible paratopes that can recognize protein motifs inaccessible to classical antibodies. This study reported four VNARs binders (JM-2,
Yu-Lei Chen +9 more
openaire +2 more sources
Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF165 Neutralization
Marine Drugs, 2018 Variable new antigen receptor domain (vNAR) antibodies are novel, naturally occurring antibodies that can be isolated from naïve, immune or synthetic shark libraries. These molecules are very interesting to the biotechnology and pharmaceutical industries
Tanya A. Camacho-Villegas +6 more
doaj +1 more source