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Impact of shelterin complex on telomere accessibility
Biophysical Journal, 2022ABSTRACT Shelterin plays critical roles in maintaining and protecting telomeres by regulating access of various physiological agents to telomeric DNA. We present single molecule measurements investigating the impact of the POT1 and a four-component shelterin complex on the accessibility of human telomeric DNA overhangs with ...
Sajad Shiekh +7 more
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Shelterin complex at telomeres: Roles in cancers
Gene Reports, 2021Abstract Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, have multiple roles in tumorigenesis. The shelterin complex consists of six telomere-specific proteins that are involved in the protection of the telomeres. The shelterin complex protects the telomeres from degradation, prevents the activation of unwanted repair ...
Emad Khodadadi +7 more
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Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives [PDF]
Journal of Cellular and Molecular Medicine, 2011 Aberrant telomere homeostasis is essential for cell immortality, enabling cells to evade telomere dependent senescence. Disruption of telomere structure and function in cancer cells is highly toxic as shown by detailed pre-clinical evaluation of telomerase inhibitors.
Alan E Bilsland +2 more
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Shelterin complex mutated in familial CLL [PDF]
Nature Reviews Clinical Oncology, 2016 exaly +2 more sources
Sequence analysis of the shelterin telomere protection complex genes in dyskeratosis congenita
Journal of Medical Genetics, 2011Background Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterised by dystrophic nails, abnormal skin pigmentation and oral leukoplakia. Patients are at very high risk of cancer and other medical problems. They have exceedingly short telomeres for their age and approximately 60% have a
Sharon A, Savage +6 more
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A child with severe form of dyskeratosis congenita and TINF2 mutation of shelterin complex
Pediatric Blood & Cancer, 2010A 26-month-old male presented with bone marrow failure and dystrophic nail lesions mimicking onychomycosis. There was no skin finding. Treatment with androgen and methylprednisolone was started due to unavailability of a matched-related hematopoietic stem cell donor. After 30 months, transfusion support was required.
Zengin, Emine +2 more
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Journal of Hepatology, 2013 Hepatocellular carcinomas (HCCs) expressing "stemness"-related markers have been associated with aggressive biological behavior and poor prognosis. We examined the relationship between "stemness"-related protein expression and telomere length, hTERT and shelterin complex protein expression and chromosomal instability.Quantitative fluorescent in situ ...
Yoo-Seok Yoon +2 more
exaly +4 more sources
Exploring the role of Shelterin complex and telomerase activity in Multiple Myeloma
Clinical Lymphoma Myeloma and Leukemia, 2015bEMD at presentation was comparable to the patients without EMD, and was significantly better than the patients with sEMD P 0.05. Conclusion: The clinical features of MM patients with bEMD were different from the patients with sEMD. Outcome of this population was significantly better than the patients with sEMD, and was comparable to the patients ...
R. Kumar +4 more
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La protection des extrémités des chromosomes eucaryotes est vitale pour la stabilité du génome. Chez les mammifères, le complexe Shelterine est responsable de cette protection car il inhibe la réponse aux cassures double brin et les machineries de réparation.
Claire GHILAIN +2 more
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Claire GHILAIN +2 more
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European Respiratory Journal, 2013
Introduction: IPF is an adult-onset, lethal lung disease of unknown etiology. Reports linking telomerase mutations to familial IPF suggest that reduced telomerase activity and telomere shortening are key factors in disease pathogenesis. Accelerated telomere shortening is also observed in sporadic IPF in the absence of gene mutations. We therefore aimed
Martina Korfei +7 more
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Introduction: IPF is an adult-onset, lethal lung disease of unknown etiology. Reports linking telomerase mutations to familial IPF suggest that reduced telomerase activity and telomere shortening are key factors in disease pathogenesis. Accelerated telomere shortening is also observed in sporadic IPF in the absence of gene mutations. We therefore aimed
Martina Korfei +7 more
openaire +1 more source