Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations. [PDF]
Genes DevSánchez-Vázquez R +5 more
europepmc +1 more source
Editorial: Novel insights connecting telomere biology to cancer development and progression
Frontiers in OncologyEkta Khattar, Erica Salvati
doaj +1 more source
Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells. [PDF]
Nat Cell BiolMarkiewicz-Potoczny M +8 more
europepmc +1 more source
Chromosomal Instability and Telomere Attrition in Systemic Sclerosis: A Historical Perspective. [PDF]
Genes (Basel)Artlett CM.
europepmc +1 more source
Telomere Maintenance and DNA Repair: A Bidirectional Relationship in Cancer Biology and Therapy. [PDF]
Cancers (Basel)Rembiałkowska N +9 more
europepmc +1 more source
Telomere-Related Gene Networks in the Ovary Shift Across Environmental Factors. [PDF]
J Exp Zool A Ecol Integr PhysiolWolf SE, George EM, Dong J, Rosvall KA.
europepmc +1 more source
Recent progress in human telomerase structure and its therapeutic targeting. [PDF]
Front Mol BiosciAlmansoori ME +5 more
europepmc +1 more source
Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1
Leonard-Booker C +6 more
europepmc +1 more source
Shelterin is a dimeric complex with extensive structural heterogeneity [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Abstract Human shelterin is a six-subunit complex – comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1 – that binds telomeres, protects them from the DNA-damage response, and regulates the maintenance of telomeric DNA. Although high-resolution structures have been generated of the individual structured domains within shelterin, the ...
John C Zinder +2 more
exaly +3 more sources