Results 91 to 100 of about 4,729 (146)

POT1 Shelterin Complex Mutations Promote Genomic Instability in CLL [PDF]

Cancer Discovery, 2013
Abstract Somatic POT1 mutations occur frequently in CLL and induce telomeric and chromosomal aberrations.
openaire   +1 more source

New players in end-protection: LIM-domain proteins associate with the shelterin complex

Aging, 2010
One of the vital activities performed by telomeres is the protection of chromosome ends. This allows cells to distinguish the tip of linear chromosomes from sites of DNA damage, and to prevent end-to-end chromosome fusions. The protective function of telomeres is lost when telomeres become critically short; a condition that is frequently found in aging
openaire   +2 more sources

α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway

Antioxidants
Cellular senescence is a hallmark of aging characterized by irreversible growth arrest and functional decline. Progressive telomeric DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger
Marianna Kapetanou, Sophia Athanasopoulou, Andreas Goutas, Dimitra Makatsori, Varvara Trachana, Efstathios Gonos   +5 more
doaj   +1 more source

Analysis of telomere length variation and Shelterin complex subunit gene expression changes in ethanol-exposed human embryonic stem cells. [PDF]

J Psychiatr Res, 2021
Moazzam M, Yim T, Kumaresan V, Henderson DC, Farrer LA, Zhang H.   +5 more
europepmc   +1 more source

Shelterin complex and digestive system tumor

World Chinese Journal of Digestology, 2012
Si-Yu Hao, Jing-Cui Yu
openaire   +1 more source

The structure of Poz1-Tpz1 reveals a dimerization module in the fission yeast shelterin complex

, 2014
Linear eukaryotic chromosomes are characterized by having distinct DNA ends. These ends, designated telomeres, are threatened by continued shortening in replication, nucleolytic degradation and unwanted fusion by the DNA-repair machinery. In order to counteract these processes, eukaryotic cells have evolved a protective cap, designated shelterin, which
openaire   +2 more sources

Abstract 1538: Understanding telomere-loop regulation by shelterin protein complex

Journal of Biological Chemistry, 2023
Joana Pashaj, Bianca Chavez, Ci Ji Lim
openaire   +1 more source

A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation. [PDF]

Neoplasia, 2019
Bilsland AE, Liu Y, Turnbull A, Sumpton D, Stevenson K, Cairney CJ, Boyd SM, Roffey J, Jenkinson D, Keith WN.   +9 more
europepmc   +1 more source

Heat stress and stocking density disrupt telomere maintenance through shelterin complex dysregulation and oxidative damage in broiler chickens. [PDF]

BMC Vet Res
Bahadoran S, Hashemi S, Hassanpour H.
europepmc   +1 more source

Initiation of Pulmonary Fibrosis after Silica Inhalation in Rats is linked with Dysfunctional Shelterin Complex and DNA Damage Response. [PDF]

Sci Rep, 2019
Shoeb M, Mustafa GM, Joseph P, Umbright C, Kodali V, Roach KA, Meighan T, Roberts JR, Erdely A, Antonini JM.   +9 more
europepmc   +1 more source