Results 71 to 80 of about 4,729 (146)

Type 2 Diabetes From the Perspective of Telomere Biology

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
This graphical abstract illustrates the bidirectional relationship between the telomere/telomerase system and T2DM: telomere attrition contributes to pancreatic β‐cell dysfunction and insulin resistance through mechanisms such as oxidative stress and apoptosis, while T2DM‐related hyperglycemia and chronic inflammation further exacerbate telomere damage.
Hongye Cao, Haixia Feng, Zhen Shen, Yanqin Huang   +3 more
wiley   +1 more source

Loss of telomere protection: consequences and opportunities.

Frontiers in Oncology, 2013
Telomeres are repetitive sequences at the natural ends of linear eukaryotic chromosomes that protect these from recognition as chromosome breaks. Their ability to do so critically depends on the binding of sufficient quantities of functional shelterin, a
Jacqueline Johanna Leonarda Jacobs
doaj   +1 more source

The shelterin component TRF2 mediates columnar stacking of human telomeric chromatin

The EMBO Journal, 2023
Telomere repeat binding factor 2 (TRF2) is an essential component of the telomeres and also plays an important role in a number of other non-telomeric processes.
Sook Yi Wong, Aghil Soman, Nikolay Korolev, Wahyu Surya, Qinming Chen, Wayne Shum, John van Noort, Lars Nordenskiöld   +7 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

Structural and functional analysis of the human POT1-TPP1 telomeric complex

Nature Communications, 2017
POT1 and TTP1 are part of the shelterin complex that caps and stabilizes the ends of telomeres. Here the authors present a structural analysis of the human POT1-TTP1 complex, shedding light on how it assembles and how cancer-associated mutations impact ...
Cory Rice, Prashanth Krishna Shastrula, Andrew V. Kossenkov, Robert Hills, Duncan M. Baird, Louise C. Showe, Tzanko Doukov, Susan Janicki, Emmanuel Skordalakes   +8 more
doaj   +1 more source

Clinical, genetic, and familial features of POT1 tumor predisposition syndrome

Cancer, Volume 132, Issue 4, 15 February 2026.
Abstract Background Protection of telomere 1 (POT1) tumor predisposition syndrome (POT1‐TPD) is a hereditary leukemia syndrome that is identified in ∼5% of patients with chronic lymphocytic leukemia (CLL) and is characterized by a predisposition to other cancers, including gliomas, melanomas, and angiosarcomas.
Courtney D. DiNardo, Jennifer Croden, Hiam M. Abdel‐Salam, Tapan Kadia, Matteo Molica, Alexandre Bazinet, Prithviraj Bose, Abhishek Maiti, Fadi Haddad, Jan Burger, Hagop Kantarjian, William Wierda, Nitin Jain, Alessandra Ferrajoli   +13 more
wiley   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Telomere length variation and expression analysis of shelterin complex genes during gallbladder carcinogenesis

Journal of Cancer Research and Therapeutics, 2017
Telomeres, which are bound with shelterin protein complex, play an important role in maintaining genomic stability and its dysfunction may lead to carcinogenesis. Here, we aimed to analyze whether shelterin complex gene expression and telomere length variation, play any role in gallbladder carcinogenesis.Telomere length analysis was carried out by ...
Satish S, Poojary, Gunja, Mishra, Tekcham Dinesh, Singh, Sanjiv, Gupta, Braj Raj, Shrivastav, Pramod Kumar, Tiwari   +5 more
openaire   +2 more sources

The WHO Classification of Genetic Tumour Syndromes: Considerations for histopathology

Histopathology, Volume 88, Issue 7, Page 1291-1294, June 2026.
Ian A Cree, Mark J Arends, Joseph D Khoury, Erika RE Denton, Anthony J Gill, Alexander J Lazar, Ian M Frayling, Stefan M Pfister, Mark A Rubin, Katia RM Leite, Raymond Dalgleish, Elspeth A Bruford, Sharon Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source