Results 81 to 90 of about 4,729 (146)
Liquid–Liquid Phase Separation in Major Hallmarks of Cancer
Cell Proliferation, Volume 59, Issue 2, February 2026.Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie +10 more
wiley +1 more source
Phylointeractomics reconstructs functional evolution of protein binding
Nature Communications, 2017 Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution.
Dennis Kappei +10 more
doaj +1 more source
Retrovirology, 2005 Background The functional state of human telomeres is controlled by telomerase and by a protein complex named shelterin, including the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 involved in telomere capping functions.
Gilson Eric +6 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Mechanistic pathways of PIK3R1 in skin aging and rejuvenation were analyzed by bioinformatics approach and Gene Expression Omnibus database. Compared with young skin, PIK3R1 was differentially expressed in aged and IPL rejuvenated skin. Coexpression and network analyses revealed that PIK3R1 jointly participated in skin aging and rejuvenation via PI3K ...
Zhike Zhou +8 more
wiley +1 more source
Multiple cancer pathways regulate telomere protection
EMBO Molecular Medicine, 2019 Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cancer. In addition,
Leire Bejarano +9 more
doaj +1 more source
Treating Cancer by Targeting Telomeres and Telomerase
Antioxidants, 2017 Telomerase is expressed in more than 85% of cancer cells. Tumor cells with metastatic potential may have a high telomerase activity, allowing cells to escape from the inhibition of cell proliferation due to shortened telomeres. Human telomerase primarily
Marko Ivancich +6 more
doaj +1 more source
Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review
Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng +8 more
wiley +1 more source
Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.
PLoS Genetics, 2009 The checkpoint kinases ATM and ATR are redundantly required for maintenance of stable telomeres in diverse organisms, including budding and fission yeasts, Arabidopsis, Drosophila, and mammals.
Bettina A Moser +4 more
doaj +1 more source
PRKN‐Mediated Ubiquitin‐Proteasome Degradation of METTL3 Promotes Cellular Senescence
Aging Cell, Volume 25, Issue 1, January 2026.Schematic diagram of model for PRKN mediate METTL3 proteasome degradation promoting cellular senescence. The left panel shows a high abundance of METTL3 expression in young cells. METTL3 mediates m6A modification on TRF2 and POT1 mRNA, leading to their high expression and maintaining telomere stability.
Liping Chen +14 more
wiley +1 more source
TELOMERES AND TELOMERASE COMPLEX. THE MAIN CLINICAL MANIFESTATION OF GENETIC MALFUNCTIONING
Кардиоваскулярная терапия и профилактика, 2015 Telomeres and telomerase complex have got be known by scientists not long ago. At the current moment there quite large data on this topic collected.
О. М. Drapkina, R. N. Shepel
doaj +1 more source