Results 201 to 210 of about 79,021 (275)

SHH drives gastric cancer-associated fibroblast activation via ACLY-dependent acetyl-CoA metabolism and histone acetylation. [PDF]

Discov Oncol
Zhang X, Sun L, Zhang Y, Wang Y, Huang Y, Jiang Y, Wang D.   +6 more
europepmc   +1 more source

Human Blood‐Brain Tumor Barrier on a Chip to Investigate Personalized Treatment for Glioblastoma Patients

Small, Volume 22, Issue 49, 1 September 2026.
A microfluidic model of the glioblastoma (GBM) margin was developed to mimic patient‐specific blood‐brain tumor barrier (BBTB) function and drug response. The platform revealed inter‐patient variability in barrier integrity and drug sensitivity, offering a tool for personalized therapy evaluation in GBM.
Minsu Ryoo, Gaeun Lee, Jinwoo Jung, Sujin Cho, Sharon Jeeho Ham, Nayeong Kang, Hyeongjin Ahn, Yu Jin Kim, JeongMin Sim, Jeongman Park, Juwon Kim, Sohyun Hwang, Jihwan Yoo, Youn‐Jung Kang, Jaejoon Lim, Jungho Ahn, Song Ih Ahn   +16 more
wiley   +1 more source

Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration. [PDF]

Int J Mol Sci
Jo IY, Kim JW, Kim JK, Shin JO.
europepmc   +1 more source

Molecular Mechanisms of Age‐Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics

Aging Cell, Volume 25, Issue 9, September 2026.
Multi‐omics profiling reveals that aging impairs stem/progenitor cell differentiation and taste bud regeneration in the posterior tongue. Age‐related macrophage polarization remodeling, marked by the accumulation of pro‐inflammatory M1 macrophages, contributes to a Thbs1‐enriched inhibitory niche that limits taste cell growth and differentiation ...
Wandong Zhao, Xudong Cha, Yingqi Xie, Enhao Wang, Wenlu Xing, Zengyi Xu, Langchao Liang, Changhai Xiong, Morong Zhou, Penghui Fu, Zhe Wang, Xin Liu, Yiqun Yu, Huanhai Liu, Hanbo Li, Wenwen Ren   +15 more
wiley   +1 more source

Sonic hedgehog reduces alveolar bone resorption by triggering the coupling of type H vessel formation and osteogenesis in a periodontitis model. [PDF]

BMC Oral Health
Zhou H, Qi YX, Ma SY, Liu J, Zhu CH, Yu SC, Li A, Pei DD.   +7 more
europepmc   +1 more source

Molecular and clinical features of a Japanese medulloblastoma cohort: Subgroup‐specific prognostic stratification using economical/accessible diagnostic methods

Brain Pathology, Volume 36, Issue 5, September 2026.
This study characterizes the molecular subgroup–specific features of a nationwide Japanese cohort comprising 242 medulloblastomas (MBs). Furthermore, we introduce SEE‐6‐CNA, a simple, cost‐effective, and FFPE‐compatible molecular test that is applicable to routine pathology samples and serves as a surrogate for risk stratification in non‐WNT/non‐SHH ...
Kohichi Go, Asako Katsuma, Ema Yoshioka, Tomoko Shofuda, Kohei Fukuoka, Koichi Ichimura, Yuko Matsushita, Yohei Mineharu, Yasuhide Makino, Takeshi Kawauchi, Atsushi Sasaki, Junko Hirato, Takeshi Inoue, Yoshinori Kodama, Masayuki Mano, Daisuke Kanematsu, Noriyuki Kijima, Naoki Kagawa, Dai Keino, Akitake Mukasa, Tomonari Suzuki, Koji Yoshimoto, Daisuke Kuga, Keishi Horiguchi, Shigeru Yamaguchi, Masayuki Kanamori, Kai Yamasaki, Kenichi Ishibashi, Takuya Akai, Masayoshi Yamaoka, Ryuji Ishizaki, Atsufumi Kawamura, Shigeo Ohba, Joji Ishida, Ryo Ando, Junya Fukai, Tomoru Miwa, Masazumi Fujii, Ai Muroi, Kuniaki Saito, Atsuko Harada, Yasuhiko Hayashi, Masahiro Nonaka, Young‐Soo Park, Yusuke Kobayashi, Tadashi Higuchi, Yosuke Miyairi, Kazuhisa Yoshifuji, Noriyoshi Takebe, Soichi Oya, Kosuke Nakajo, Mitsutoshi Nakada, Yoshiteru Nakano, Mizuki Kambara, Koji Adachi, Kazuhiro Tanaka, Hideo Nakamura, Yukihiko Sonoda, Ryuta Saito, Takafumi Wataya, Kazuhiko Kurozumi, Michael D. Taylor, Yoshitaka Narita, Soichiro Shibui, Hajime Arai, Hiroaki Sakamoto, Isao Date, Motoo Nagane, Ryo Nishikawa, Yoshiki Arakawa, Yonehiro Kanemura   +70 more
wiley   +1 more source

PCK2 as a potential therapeutic target for aggressive MYC-amplified non-WNT/non-SHH medulloblastoma based on tumor continuum. [PDF]

Acta Neuropathol Commun
Xue S, Zhan Z, Cai Y, Chen W, Chen R, Mao Y, Xie C, Liu J, Luo Z, Liu S, Zhang X, Li P, Long H, Song Y.   +13 more
europepmc   +1 more source

Medulloblastoma - SHH subtype

, 2020
openaire   +1 more source

Human iPSC‐Derived Brain Organoids: A Disease‐Oriented Evaluation of Modeling Fidelity

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
Organoids are self‐organizing 3D structures that mimic organ architecture and function with multiple cell types arranged in spatial patterns. Brain organoids can be patterned towards specific regions and can incorporate glial and microglial components.
Bishwa R. Pokharel, Abigail Dickerson, Sanjana G. Shenoy, Mira S. Ramasamy, Niska Majumdar, Paul P. Cook, Shaw M. Akula   +6 more
wiley   +1 more source

RAC1 regulates Sonic Hedgehog-medulloblastoma growth via GLI-mediated transcription. [PDF]

Neuro Oncol
Jangde N, Lee MH, Ruiz L, Egan I, Jermakowicz AM, Chowdary R, Chu J, Wynn DT, Goka E, Lippman M, Robbins DJ, Ayad NG.   +11 more
europepmc   +1 more source