Results 191 to 200 of about 79,021 (275)

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Mechanistic trade-offs between local and long-range signaling activity in natural and synthetic morphogens. [PDF]

Sci Adv
Schlissel G, Hansen AS, Li P.
europepmc   +1 more source

My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley   +1 more source

Posterior shift of Shh-Fgf signaling in axolotl limb regeneration drives sequential digit formation. [PDF]

iScience
Furukawa S, Yamamoto S, Nakayama H, Ohashi A, Satoh A.   +4 more
europepmc   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Lipidomic analysis of isolated lipid droplets reveals potential metabolic pathway differences between medulloblastoma subgroups. [PDF]

Front Neurosci
Cotton K, Stafford J, Edwards C, Niklison-Chirou MV.   +3 more
europepmc   +1 more source

Update on the Pathophysiology, Aetiology and Management of Central Sleep Apnoea

Respirology, Volume 31, Issue 9, Page 873-881, September 2026.
ABSTRACT Central sleep apnoea (CSA) of the periodic breathing type occurs during the transition between wakefulness and stage 1 and 2 non‐REM sleep. In adults at sea level, it occurs most commonly due to advanced heart failure (HF) or chronic opioid use and in ~5% of obstructive sleep apnoea patients initiating CPAP.
Sahan D. Chandrasekara, Matthew T. Naughton   +1 more
wiley   +1 more source

High Corticosterone Affects Somite Development During Early Avian Embryogenesis. [PDF]

Biomolecules
Nursimulu DA, Heiß A, Song J, Jahns H, Pugo-Gunsam P, Schneider-Stock R.   +5 more
europepmc   +1 more source

SHH wt Allele [PDF]

, 2020
openaire   +1 more source

Age‐related population level decoupling of obstructive sleep apnea severity from body mass index: Insights from over 40,000 patients across the adult lifespan

Sleep Research, Volume 3, Issue 3, Page 223-231, September 2026.
Abstract Study Objectives Obesity is a major determinant of obstructive sleep apnea (OSA) severity, but its influence may vary across adulthood. We examined age‐related patterns of body mass index (BMI), apnea–hypopnea index (AHI), and hypoxemic burden, and assessed whether the association between BMI and OSA severity attenuates with age.
Peretz Lavie
wiley   +1 more source