Results 181 to 190 of about 74,513 (285)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

The nociceptor primary cilium. [PDF]

Brain
Ganter GK, Reveche HC, Fitzsimons LA, Khomula EV, Levine JD, Tucker KL.   +5 more
europepmc   +1 more source

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12 ‐Related Developmental Disorders

American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1619-1650, July 2026.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Subtype-specific prognostic impact of TNIK in medulloblastoma. [PDF]

J Neurooncol
Klaus FL, Maragkou T, Delbridge C, Eberhardt CG, Hewer E, Gocke A, Radpour R, Mawrin C, Mogler C, Neumann JE, Forster S.   +10 more
europepmc   +1 more source

Primary cilia–extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Alzheimer's disease (AD) is a neurodegenerative condition marked by cognitive decline and synaptic issues. Recent studies show primary cilia (PCs), sensory organelles present on the surface of most mammalian cells, act as a critical regulators of brain homeostasis and signaling.
Vishal Singh Guleria, Charisse N. Winston   +1 more
wiley   +1 more source

Roles of sonic hedgehog signaling in retinal patterning and neurogenesis during mammalian eye development. [PDF]

Development
Krueger MR, Cheema SK, Simo S, Levine EM, Brown NL, La Torre A.   +5 more
europepmc   +1 more source

PVT1 lincRNA signals an androgen‐dependent transcriptional activation program of oncogenes in prostate cancer cells

International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.
What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho, Fabio Nunes de Mello, Ana Carolina Tahira, Gabriel Nakanishi Fortes, Agatha Fischer‐Carvalho, Pedro Jardim Poli, Murilo Sena Amaral, Sergio Verjovski‐Almeida   +7 more
wiley   +1 more source

A 10-year-long ongoing complete response to vismodegib as first-line treatment in adult metastatic medulloblastoma. [PDF]

Acta Oncol
Abdi S, Poikonen-Saksela P, Halonen P, Tynninen O, Reardon DA, Hernberg M.   +5 more
europepmc   +1 more source

Targeting Cilia Initiation & Maintenance in Shh-MB

The 62nd Annual Medical Student Research Forum at UT Southwestern Medical Center (Tuesday, January 30, 2024, 3-6 p.m., D1.700 Lecture Hall)Medulloblastoma (MB) is the most common malignant pediatric brain tumor.
Popokh, Benjamin
core  

The Reliability of Intraoperative Frozen Section for Glottic Lesions Suspected of Early Malignancy

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 1, Page 173-180, July 2026.
Abstract Objective Glottic lesions suspected of malignancy may be treated by laser cordectomy. Although obviating the preoperative biopsy can expedite treatment and preserve the surgical planes, it poses a risk of mistreatment. This study sought to determine if intraoperative frozen section (FS) prior to cordectomy can reliably guide lesion management.
Gal Levi, Yaniv Hamzany, Nir Tsur, Yulia Strenov, Daniel Ben‐Ner, Hagit Shoffel‐Havakuk   +5 more
wiley   +1 more source