Results 61 to 70 of about 24,858 (221)

Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways. [PDF]

PLoS Computational Biology, 2013
Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of "one-disease, one-target, one-drug".
Kai-Cheng Hsu, Wen-Chi Cheng, Yen-Fu Chen, Wen-Ching Wang, Jinn-Moon Yang   +4 more
doaj   +1 more source

Biosynthesis of α-Tocopherol and Plastoquinone-9 in spinach chloroplasts [PDF]

, 1980
Prenylation and methylation reaction in al biosynthesis is localized in the envelope membranes of the chloroplasts, while PQ-9 biosynthesis takes place in the envelope membranes and also in the thylakoid membranes.
Mazliak, P., Schultz, Gernot, Soll, Jürgen   +2 more
core   +1 more source

Thirty years of glyphosate‐resistant crops and weeds: Current situation and future prospects

Pest Management Science, EarlyView.
Since 1996, when the first glyphosate‐resistant crop was commercialized and the first resistant weed was reported, resistance has expanded globally. This review analyzes emergence patterns across weed species, crops, regions, resistance mechanisms, and herbicides.
Ricardo Alcántara‐de la Cruz, Yure Marin Guidi, Mariana Ramirez‐Castillo, Fernando Storniolo Adegas, Caio Antonio Carbonari, Edivaldo Domingues Velini, Rafael De Prado, Stephen O. Duke   +7 more
wiley   +1 more source

Engineering 2-Pyrone-4,6-Dicarboxylic Acid Production Reveals Metabolic Plasticity of Poplar. [PDF]

Plant Biotechnol J
ABSTRACT Woody biomass is a promising source of fermentable sugars for biofuels and bio‐based chemicals, but its industrial use is limited by the costly biorefinery process. A viable strategy to reduce costs involves enhancing both biomass processability and the generation of high‐value co‐products.
Dwivedi N, Ji P, Tian Y, Kaur D, Vulavala VKR, Tobimatsu Y, Eudes A, Liu CJ.   +7 more
europepmc   +2 more sources

Location of chlorogenic acid biosynthesis pathway and polyphenol oxidase genes in a new interspecific anchored linkage map of eggplant [PDF]

, 2014
© Gramazio et al.; licensee BioMed Central. 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
A Bombarely, A Cho, A Concellón, A Frary, A Kumar, A Moglia, A Stàgel, AP Singh, B Menin, BD Whitaker, C Chai, C Coetzer, C Comino, C Comino, C Ma, C Urbany, CM André, CM Rommens, D Chagné, D Kosambi, D Luthria, E Portis, E Portis, E Portis, EC Ramirez, Elena Castillo, F Wu, F Wu, Francisco Javier Herraiz, G Mennella, H Fukuoka, H Fukuoka, Isabel Andújar, J Doyle, J Prohens, J Prohens, J Van Ooijen, Jaime Prohens, JR Stommel, K Shirasawa, K Yamakawa, KV Alheit, L Barchi, L Barchi, L Barchi, L Tran, M Di Guardo, M Doğan, M Jeuken, M Krzywinski, M Murata, M Plazas, M Plazas, Mariola Plazas, MC Daunay, MD Dos Santos, MD Raigón, P Byrne, P Vos, Pietro Gramazio, PM Hanson, R Kofler, R Lo Scalzo, R Niggeweg, R Shi, Rachel S Meyer, RN Lester, S Doganlar, S Doganlar, S Knapp, S Rozen, S Vilanova, Sandra Knapp, Santiago Vilanova, SM Newman, SM Shetty, T Nunome, T Nunome, T Nunome, T Vogt, TA Hall, The Angiosperm Phylogeny Group, TM Fulton, Y Ren, Z Huang   +84 more
core   +1 more source

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

The multidimensional regulation roles and mechanisms of calcium in fruit quality

Journal of Integrative Plant Biology, EarlyView.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang, Siyang Gao, Mengdi Li, Zeqi Zhao, Chengwei Yang, Ji‐Hong Liu, Chunlong Li   +6 more
wiley   +1 more source

Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds—Present and Future Strain Construction Strategies

Frontiers in Bioengineering and Biotechnology, 2018
The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced secondary metabolites.
Nils J. H. Averesch, Jens O. Krömer
doaj   +1 more source

The acanthamoeba shikimate pathway has a unique molecular arrangement and is essential for aromatic amino acid biosynthesis [PDF]

, 2015
The shikimate pathway is the only known biosynthetic route for de novo synthesis of aromatic compounds. It is described as an ancient eukaryotic innovation that has been retained in a subset of eukaryotes, replaced in plants through the acquisition of ...
Campbell, Sara J., Cano, Antonella, Henriquez, Fiona L., Muench, Stephen P., Roberts, Craig W., Sundararaj, Bharath K.   +5 more
core   +1 more source

Cell‐type‐specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves

New Phytologist, EarlyView.
Summary In plants, multiple cell types contribute to immunity, but what division of labor exists among cell types when immunity is activated? We compared, at single‐cell resolution, the response of Arabidopsis thaliana leaf cells during pattern‐triggered and effector‐triggered immunity (PTI/ETI), sampled at 3 and 5 h after infection with Pseudomonas ...
Shanshan Wang, Ilja Bezrukov, Pin‐Jou Wu, Hannah Gauß, Marja Timmermans, Detlef Weigel   +5 more
wiley   +1 more source