Results 91 to 100 of about 9,573 (184)

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy, Sivaraman Arumugam, Robin Charles Antony Arulraj, Anne Wincy Jacob Thomas, Henrique D. M. Coutinho   +4 more
wiley   +1 more source

Transcriptome profiling of grapevine seedless segregants during berry development reveals candidate genes associated with berry weight [PDF]

, 2016
Indexación: Web of Science; PubMedBackground Berry size is considered as one of the main selection criteria in table grape breeding programs. However, this is a quantitative and polygenic trait, and its genetic determination is still poorly understood ...
A Doligez, A Roberts, A Zamboni, AJ Bais, Alejandro Maass, Alex Di Genova, AM Almeida, AP Friend, Ariel Orellana, AS Negri, BG Coombe, BG Coombe, BG Coombe, BM Fischer, C Chen, C Conde, C Houel, C Pastore, C Pratt, C Sweetman, C Trapnell, CA Ledbetter, Claudia Muñoz-Espinoza, D Costenaro da Silva, D Lijavetzki, D Moreno, D Schenck, DH Lorenz, F Carrari, F Dyda, FG Silva da, FJ Pérez, G Fanizza, GR Cramer, I Debeaujon, J Correa, J Correa, J Guo, J Tello, J Xu, JA Cabezas, José Correa, JP Nitsch, K Chen, K Yang, KCH Amrine, L Bogrë, L Costantini, L Deluc, L Fernandez, M Barticevic, M Chakrabarti, M Fasoli, M González-Agüero, M Lu, M Rienth, M Salmaso, Mauricio González-Agüero, MB Ali, MC Palumbo, MJ Carmona, MJ Martínez-Esteso, MK Aradhya, N Mejía, N Mejía, N Schumann, N Wang, N Yokotani, NS Watson-Haigh, O Gudenschwager, O Jaillon, P Barba, P Langcake, P Neudecker, P Nicolas, Patricio Hinrichsen, R Core Team, R Ursem, Romina Silva, S Dal Santo, S Epskamp, S Guillaumie, S Lê, S Myles, S Taylor, S Zenoni, SBP Athauda, T Sekito, T Wei, X Chen, Z Du   +90 more
core   +3 more sources

19F NMR as a Molecular Reporter: Labelling Strategies and Methods for Probing Biomolecular Motion and Exchange

Chemistry–Methods, Volume 6, Issue 2, February 2026.
This review summarizes the unique benefits 19F NMR spectroscopy has to offer for the study of biological systems. Particular focus is laid on the available strategies for incorporation of fluorinated probes into proteins and the latest applications of the ever‐expanding toolbox of fluorine NMR methodology to study structure and dynamics.
Charles Burridge, Björn M. Burmann
wiley   +1 more source

Molecular Hybridization of Naphthoquinones as Selective Inhibitors of Shikimate Kinase: A Promising Strategy Against Mycobacterium tuberculosis

Drugs and Drug Candidates
Background: Tuberculosis (TB) remains a critical global health concern, exacerbated by the emergence of multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis.
Beatriz C. T. de Oliveira, Dandara de Paula Candido, Acácio S. de Souza, Iva S. de Jesus, Fernando de C. da Silva, Leonardo Bruno P. F. Barreto, Samyra A. da Silveira, Yrneh Y. P. Palacios, Francisco das C. de Souza, Maria Cristina S. Lourenço, Carlos Mauricio R. Sant’Anna, Vitor F. Ferreira, Alcione S. de Carvalho   +12 more
doaj   +1 more source

Nidulantes of Aspergillus (Formerly Emericella): A Treasure Trove of Chemical Diversity and Biological Activities

Metabolites, 2020
The genus Emericella (Ascomycota) includes more than thirty species with worldwide distribution across many ecosystems. It is considered a rich source of diverse metabolites.
Najla Ali Alburae, Afrah E. Mohammed, Hajer Saeed Alorfi, Adnan Jaman Turki, Hani Zakaria Asfour, Walied Mohamed Alarif, Ahmed Abdel-Lateff   +6 more
doaj   +1 more source

Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria [PDF]

, 2014
Mycobacterium tuberculosis remains a major cause of death due to the lack of treatment accessibility, HIV coinfection, and drug resistance. Development of new drugs targeting previously unexplored pathways is essential to shorten treatment time and ...
Cynamon, Michael, Guinn, Kristine M., Kheterpal, Indu, Li, Xiaoqing, Locher, Christopher, Osterman, Andrei L., Rodionova, Irina A., Rubin, Eric J., Schuster, Brian M., Scott, David A., Shoen, Carolyn, Sorci, Leonardo   +11 more
core   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Modulating Enzyme–Ligand Binding with External Fields

Biophysica
Protein enzymes are highly efficient catalysts that exhibit adaptability and selectivity under diverse biological conditions. In some organisms, such as bacteria, structurally similar enzymes, for instance, shikimate kinase (SK) and adenylate kinase (AK),
Pedro Ojeda-May
doaj   +1 more source

A key role for apoplastic H2O2 in Norway spruce phenolic metabolism [PDF]

, 2017
Apoplastic events such as monolignol oxidation and lignin polymerization are difficult to study in intact trees. To investigate the role of apoplastic hydrogen peroxide (H2O2) in gymnosperm phenolic metabolism, an extracellular lignin-forming cell ...
Boerjan, Wout, Brader, Gunter, Delhomme, Nicolas, Gauthier, Adrien, Karkonen, Anna, Laitinen, Teresa, Lim, Kean-Jin, Morreel, Kris, Nickolov, Kaloian, Schiffthaler, Bastian, Street, Nathaniel R, Teeri, Teemu H   +11 more
core   +4 more sources

Comparison of Predatory Phenotypes and Genotypes Between Bdellovibrio sp. BIS2 and Bacteriovorax sp. HI3 Isolated From the Same Freshwater Environment

Environmental Microbiology, Volume 28, Issue 1, January 2026.
Bdellovibrio and like organisms (BALOs) have gained attraction owing to their ecological and practical significance. This study comparatively investigated two BALO strains from the same freshwater pond, Bdellovibrio sp. BIS2 and Bacteriovorax sp. HI3, and revealed significant variation in their predatory behaviours and associated genetic profiles ...
Tomomi Sugiyama, Tsubasa Kojima, Naoki A. Uemura, Daisuke Nakane, Hideo Dohra, Daisuke Inoue, Michihiko Ike   +6 more
wiley   +1 more source