The effect on shikimate production by deleting <i>iolR</i> and metabolic engineering in PTS deficient <i>Corynebacterium glutamicum</i> strain. [PDF]
Ou RW +4 more
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Plant Immunometabolism: Metabolic Reprogramming Linking Developmental Signaling and Defense Metabolites. [PDF]
Zaman W, Ayaz A, Amin A.
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Chemoinformatic Approaches to Identify Bioactive Inhibitors Against Type I Dehydroquinase (DHQ1) Enzyme of Typhoidal <i>Salmonella</i>. [PDF]
Ashfaq A +4 more
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Expanding the substrate spectrum in engineered Pseudomonas taiwanensis for efficient production of 4-coumarate from lignocellulosic sugars. [PDF]
Wynands B +4 more
europepmc +1 more source
Physiological metabolic analysis and process optimization of hypoxia in promoting coenzyme Q<sub>10</sub> biosynthesis and accumulation in <i>Rhodobacter sphaeroides</i> HY01. [PDF]
Li B +9 more
europepmc +1 more source
Integrated genomic and phenotypic analysis of an endophytic bacterium reveals biocontrol and plant growth-promoting mechanisms. [PDF]
Sa R +8 more
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An overview of mechanism and chemical inhibitors of shikimate kinase
Journal of Biomolecular Structure and Dynamics, 2023Tuberculosis is a highly infectious disease other than HIV/AIDS and it is one of the top ten causes of death worldwide. Resistance development in the bacteria occurs because of genetic alterations, and the molecular insights suggest that the accumulation of mutation in the individual drug target genes is the primary mechanism of multi-drug resistant ...
M K Kathiravan
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Molecular model of shikimate kinase from Mycobacterium tuberculosis
Biochemical and Biophysical Research Communications, 2002Tuberculosis (TB) resurged in the late 1980s and now kills approximately 3 million people a year. The reemergence of tuberculosis as a public health threat has created a need to develop new anti-mycobacterial agents. The shikimate pathway is an attractive target for herbicides and anti-microbial agents development because it is essential in algae ...
Fernanda Canduri +2 more
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Molecular modeling and dynamics studies of Shikimate Kinase from Bacillus anthracis
Bioorganic and Medicinal Chemistry, 2008Bacillus anthracis has been used as weapon in bioterrorist activities, with high mortality, despite anti-microbial treatment, which strongly indicates a need of new drugs to treat anthrax. Shikimate Pathway is a seven-step biosynthetic route which generates chorismic acid.
Walter F DE AZEVEDO +2 more
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Shikimate Kinase, a Protein Target for Drug Design
Current Medicinal Chemistry, 2014ATP: shikimate 3-phosphotransferase catalyzes the fifth chemical reaction of shikimate pathway. This metabolic route is responsible for the production of chorismate, a precursor of aromatic amino acids. This especially interesting enzymatic step is indispensable for the survival of the etiological agent of tuberculosis and not found in animals ...
J D, Coracini, W F, de Azevedo
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