Results 111 to 120 of about 5,044 (156)

An overview of mechanism and chemical inhibitors of shikimate kinase

Journal of Biomolecular Structure and Dynamics, 2023
Tuberculosis is a highly infectious disease other than HIV/AIDS and it is one of the top ten causes of death worldwide. Resistance development in the bacteria occurs because of genetic alterations, and the molecular insights suggest that the accumulation of mutation in the individual drug target genes is the primary mechanism of multi-drug resistant ...
M K Kathiravan
exaly   +3 more sources

Molecular model of shikimate kinase from Mycobacterium tuberculosis

Biochemical and Biophysical Research Communications, 2002
Tuberculosis (TB) resurged in the late 1980s and now kills approximately 3 million people a year. The reemergence of tuberculosis as a public health threat has created a need to develop new anti-mycobacterial agents. The shikimate pathway is an attractive target for herbicides and anti-microbial agents development because it is essential in algae ...
Fernanda Canduri   +2 more
exaly   +4 more sources

Molecular modeling and dynamics studies of Shikimate Kinase from Bacillus anthracis

Bioorganic and Medicinal Chemistry, 2008
Bacillus anthracis has been used as weapon in bioterrorist activities, with high mortality, despite anti-microbial treatment, which strongly indicates a need of new drugs to treat anthrax. Shikimate Pathway is a seven-step biosynthetic route which generates chorismic acid.
Walter F DE AZEVEDO   +2 more
exaly   +3 more sources

Shikimate Kinase, a Protein Target for Drug Design

Current Medicinal Chemistry, 2014
ATP: shikimate 3-phosphotransferase catalyzes the fifth chemical reaction of shikimate pathway. This metabolic route is responsible for the production of chorismate, a precursor of aromatic amino acids. This especially interesting enzymatic step is indispensable for the survival of the etiological agent of tuberculosis and not found in animals ...
J D, Coracini, W F, de Azevedo
openaire   +2 more sources

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