Results 161 to 170 of about 9,573 (184)

Molecular model of shikimate kinase from Mycobacterium tuberculosis

Biochemical and Biophysical Research Communications, 2002
Tuberculosis (TB) resurged in the late 1980s and now kills approximately 3 million people a year. The reemergence of tuberculosis as a public health threat has created a need to develop new anti-mycobacterial agents. The shikimate pathway is an attractive target for herbicides and anti-microbial agents development because it is essential in algae ...
De Azevedo Jr., Walter Filgueira, Canduri, Fernanda, De Oliveira, Jaim Simões, Basso, Luiz Augusto, Palma, Mario Sergio, Pereihenrra, José Henrique, Santos, Diógenes Santiago   +6 more
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Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis

Alternatives to Laboratory Animals, 2023
Over the last decade, Mycobacterium tuberculosis has mutated into a putative ‘superbug’, as treatments against it have failed due to increasing antimicrobial resistance. As a result, the rising incidence of multidrug-resistant tuberculosis (MDR-TB) is posing a significant public health threat, thus, the need to develop effective drugs for MDR-TB has ...
Ashish, Jhangiani, Vandana, Panda, Aanchal, Sukheja, Sneha, Thomas, Piyush, Dusseja, Siddhartha, Pandya, Anand, Chintakrindi   +6 more
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Shikimate Kinase, a Protein Target for Drug Design

Current Medicinal Chemistry, 2014
ATP: shikimate 3-phosphotransferase catalyzes the fifth chemical reaction of shikimate pathway. This metabolic route is responsible for the production of chorismate, a precursor of aromatic amino acids. This especially interesting enzymatic step is indispensable for the survival of the etiological agent of tuberculosis and not found in animals ...
J D, Coracini, W F, de Azevedo
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The three-dimensional structure of shikimate kinase.

Journal of molecular biology, 1998
The three-dimensional structure of shikimate kinase from Erwinia chrysanthemi has been determined by multiple isomorphous replacement. Two models are presented: a high resolution 1.9 A model and a 2.6 A model which contains bound Mg-ADP. The enzyme is an alpha/beta protein consisting of a central sheet of five parallel beta-strands flanked by alpha ...
T, Krell, J R, Coggins, A J, Lapthorn
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Mechanism of Phosphoryl Transfer Catalyzed by Shikimate Kinase from Mycobacterium tuberculosis

Journal of Molecular Biology, 2006
The structural mechanism of the catalytic functioning of shikimate kinase from Mycobacterium tuberculosis was investigated on the basis of a series of high-resolution crystal structures corresponding to individual steps in the enzymatic reaction. The catalytic turnover of shikimate and ATP into the products shikimate-3-phosphate and ADP, followed by ...
Hartmann, M. ; https://orcid.org/0000-0001-6937-5677, Bourenkov, G., Oberschall, A., Strizhov, N., Bartunik, H.   +4 more
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Shikimate Kinase Inhibitors: An Update on Promising Strategy against Mycobacterium tuberculosis

Current Drug Targets, 2023
Abstract: Humanity has been battling with tuberculosis (TB) for a long period, and despite the availability of drugs well-known to act against the deadly microbe, the menace is still very far from reaching its end. Moreover, problems related to TB chemotherapy, such as lengthy treatment peri-ods leading to poor patient compliance, increasing drug ...
Vikrant Singh, Rajput, Ashish, Runthala, Inshad Ali, Khan   +2 more
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Interaction of shikimic acid with shikimate kinase.

Biochemical and biophysical research communications, 2005
The crystal structure of shikimate kinase from Mycobacterium tuberculosis (MtSK) complexed with MgADP and shikimic acid (shikimate) has been determined at 2.3A resolution, clearly revealing the amino acid residues involved in shikimate binding. In MtSK, the Glu61 strictly conserved in SK forms a hydrogen bond and salt-bridge with Arg58 and assists in ...
José Henrique, Pereira, Jaim Simões, de Oliveira, Fernanda, Canduri, Marcio Vinicius Bertacine, Dias, Mário Sérgio, Palma, Luiz Augusto, Basso, Walter Filgueira, de Azevedo, Diógenes Santiago, Santos   +7 more
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Stimulation by thioredoxin of shikimate kinase from spinach chloroplasts

Physiologia Plantarum, 1987
The activity of shikimate kinase (EC 2.7.1.71) from spinach (Spinacia oleracea L.) chloroplasts was increased up to 8.5‐fold by addition of thioredoxin and dithio‐threitol.
C. L. Schmidt, G. Schultz
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Molecular modeling and dynamics studies of Shikimate Kinase from Bacillus anthracis

Bioorganic & Medicinal Chemistry, 2008
Bacillus anthracis has been used as weapon in bioterrorist activities, with high mortality, despite anti-microbial treatment, which strongly indicates a need of new drugs to treat anthrax. Shikimate Pathway is a seven-step biosynthetic route which generates chorismic acid.
Ivani, Pauli, Rafael Andrade, Caceres, Walter Filgueira, de Azevedo   +2 more
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Crystal Structure of Mycobacterium tuberculosis Shikimate Kinase in Complex with Shikimic Acid and an ATP Analogue^,

Biochemistry, 2006
Shikimate kinase (SK) and other enzymes in the shikimate pathway are potential targets for developing nontoxic antimicrobial agents, herbicides, and antiparasite drugs, because the pathway is essential in microorganisms, plants, and parasites but absent from mammals. SK catalyzes the reaction of phosphoryl transfer from ATP to shikimic acid (SA). Since
Jianhua, Gan, Yijun, Gu, Yue, Li, Honggao, Yan, Xinhua, Ji   +4 more
openaire   +2 more sources