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Shikimate Kinase: A Potential Target for Development of Novel Antitubercular Agents
Current Drug Targets, 2007Tuberculosis (TB) remains the leading cause of mortality due to a bacterial pathogen, Mycobacterium tuberculosis. However, no new classes of drugs for TB have been developed in the past 30 years. Therefore there is an urgent need to develop faster acting and effective new antitubercular agents, preferably belonging to new structural classes, to better ...
José H, Pereira +6 more
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Folding and stability of shikimate kinase
2002Shikimate kinase (SK; EC 2.7.1.71), an enzyme that catalyses the specific phosphorylation of the 3-hydroxyl group of shikimate using ATP as the phosphoryl donor, was chosen as a representative example of a subclass of a/p proteins with which to examine the unfolding, stability and mechanism of protein folding.
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Discovery of Helicobacter pylori shikimate kinase inhibitors: Bioassay and molecular modeling
Bioorganic & Medicinal Chemistry, 2007Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway and catalyzes the phosphate transfer from ATP to shikimate in generating shikimate 3-phosphate and ADP. SK has been developed as a promising target for the discovery of antibacterial agents.
Cong, Han +5 more
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Biochemical and Biophysical Research Communications, 2016
The molecular bases of disease provide exceptional prospect to translate research findings into new drugs. Nevertheless, to develop new and novel chemical entities takes huge amount of time and efforts, mainly due to the stringent processes. Therefore, drug repurposing is one of such strategies which is being used in recent times to identify new ...
Sapna, Pandey +5 more
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The molecular bases of disease provide exceptional prospect to translate research findings into new drugs. Nevertheless, to develop new and novel chemical entities takes huge amount of time and efforts, mainly due to the stringent processes. Therefore, drug repurposing is one of such strategies which is being used in recent times to identify new ...
Sapna, Pandey +5 more
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Effects of salts on the function and conformational stability of shikimate kinase
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003The unfolding of shikimate kinase (SK) from Erwinia chrysanthemi by urea and its subsequent refolding on dilution of the denaturing agent has been studied in detail [Eur. J. Biochem. 269 (2002) 2124]. Comparison of the effects of urea on the enzyme with those of guanidinium chloride (GdmCl) and NaCl indicated that chloride ions significantly weakened ...
Eleonora, Cerasoli +5 more
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The gene (aroK) encoding shikimate kinase I fromEscherichia coli.
DNA Sequence, 1995Shikimate kinase I (SKI), encoded by the aroK gene, converts shikimate to shikimate 3-phosphate, an intermediate in the biosynthesis of the aromatic amino acids. This paper provides evidence that the E. coli aroK reading frame is in a different place to that reported previously and presents a predicted SKI sequence of 173 residues and a molecular mass ...
H G, Griffin, M J, Gasson
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Mechanistic studies on chorismate synthase and shikimate kinase
2018This thesis was digitised by the British Library from microfilm. You can acquire a single copy of this thesis for research purposes by clicking on the padlock icon on the thesis file. Please be aware that the text in the supplied thesis pdf file may not be as clear as text in a thesis that was born digital or digitised directly from paper due to the ...
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