Functional Analysis of 3-Dehydroquinate Dehydratase/Shikimate Dehydrogenases Involved in Shikimate Pathway in Camellia sinensis [PDF]
Frontiers in Plant Science, 2019 Polyphenols play an important role in the astringent taste of tea [Camellia sinensis (L.)] infusions; catechins in phenolic compounds are beneficial to health.
Keyi Huang +10 more
doaj +6 more sources
Increased Glyphosate-Induced Gene Expression in the Shikimate Pathway Is Abolished in the Presence of Aromatic Amino Acids and Mimicked by Shikimate [PDF]
Frontiers in Plant Science, 2020 The herbicide glyphosate inhibits the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in the aromatic amino acid (AAA) biosynthetic pathway, also known as the shikimate pathway.
Ainhoa Zulet-González +4 more
doaj +3 more sources
Uncovering the Role of PhzC as DAHP Synthase in Shikimate Pathway of Pseudomonas chlororaphis HT66 [PDF]
Biology, 2022 DAHP synthase catalyzes the first step in the shikimate pathway, deriving the biosynthesis of aromatic amino acids (Trp, Phe and Tyr), phenazine-1-carboxamide, folic acid, and ubiquinone in Pseudomonas chlororaphis.
Songwei Wang +4 more
doaj +3 more sources
Computational modelling provides insight into the effects of glyphosate on the shikimate pathway in the human gut microbiome [PDF]
Current Research in Toxicology, 2020 The herbicide active ingredient glyphosate can affect the growth of microorganisms, which rely on the shikimate pathway for aromatic amino acid biosynthesis.
Robin Mesnage, Michael N. Antoniou
doaj +3 more sources
CRISPR-mediated multigene integration enables Shikimate pathway refactoring for enhanced 2-phenylethanol biosynthesis in Kluyveromyces marxianus [PDF]
Biotechnology for Biofuels, 2021 Background 2-phenylethanol (2-PE) is a rose-scented flavor and fragrance compound that is used in food, beverages, and personal care products. Compatibility with gasoline also makes it a potential biofuel or fuel additive.
Mengwan Li +6 more
doaj +3 more sources
Mycobacterium tuberculosis Shikimate Pathway Enzymes as Targets for the Rational Design of Anti-Tuberculosis Drugs [PDF]
Molecules, 2020 Roughly a third of the world’s population is estimated to have latent Mycobacterium tuberculosis infection, being at risk of developing active tuberculosis (TB) during their lifetime.
José E. S. Nunes +8 more
doaj +3 more sources
Metabolic Engineering of the Shikimate Pathway for Production of Aromatics and Derived Compounds—Present and Future Strain Construction Strategies [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced secondary metabolites.
Nils J. H. Averesch, Jens O. Krömer
doaj +3 more sources
Metabolic engineering of Escherichia coli for shikimate pathway derivative production from glucose–xylose co-substrate [PDF]
Nature Communications, 2020 In lignocellulose biomass, microbes prefer consuming glucose over xylose, which affects target compound production. Here, the authors achieve simultaneous utilization of glucose and xylose for target chemical production and cell growth, respectively, and
Ryosuke Fujiwara +3 more
doaj +3 more sources
Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms [PDF]
Nature Communications, 2019 Mother Nature is a valuable resource for the discovery of drug and agricultural chemicals. Here, the authors show that 7-deoxy-sedoheptulose produced by a cyanobacterium is an antimicrobial and herbicidal compound that acts through inhibition of 3 ...
Klaus Brilisauer +8 more
doaj +3 more sources
Engineering of Shikimate Pathway and Terminal Branch for Efficient Production of L-Tryptophan in Escherichia coli. [PDF]
Int J Mol Sci, 2023 L-tryptophan (L-trp), produced through bio-manufacturing, is widely used in the pharmaceutical and food industries. Based on the previously developed L-trp-producing strain, this study significantly improved the titer and yield of L-trp, through ...
Liu S, Wang BB, Xu JZ, Zhang WG.
europepmc +2 more sources