The shikimate pathway: gateway to metabolic diversity. [PDF]
Nat Prod RepCovering: 1997 to 2023The shikimate pathway is the metabolic process responsible for the biosynthesis of the aromatic amino acids phenylalanine, tyrosine, and tryptophan.
Shende VV, Bauman KD, Moore BS.
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Mechanistic investigation of a D to N mutation in DAHP synthase that dictates carbon flux into the shikimate pathway in yeast. [PDF]
Commun Chem, 2023 3-deoxy-D- arabino -heptulosonate-7-phosphate synthase (DAHPS) is a key enzyme in the shikimate pathway for the biosynthesis of aromatic compounds. _L-Phe and _L-Tyr bind to the two main DAHPS isoforms and inhibit their enzyme activities, respectively ...
Liu H +8 more
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Isolation and Identification of Non-Saccharomyces Yeast Producing 2-Phenylethanol and Study of the Ehrlich Pathway and Shikimate Pathway. [PDF]
J Fungi (Basel), 2023 2-phenylethanol (2-PE) has been widely utilized as an aromatic additive in various industries, including cosmetics, beer, olive oil, tea, and coffee, due to its rose-honey-like aroma.
Zhou R +9 more
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An Evolutionary Conservation and Druggability Analysis of Enzymes Belonging to the Bacterial Shikimate Pathway. [PDF]
Antibiotics (Basel), 2022 Enzymes belonging to the shikimate pathway have long been considered promising targets for antibacterial drugs because they have no counterpart in mammals and are essential for bacterial growth and virulence.
Frlan R.
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The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation. [PDF]
Plant Cell, 2021 The plant shikimate pathway directs bulk carbon flow toward biosynthesis of aromatic amino acids (AAAs, i.e. tyrosine, phenylalanine, and tryptophan) and numerous aromatic phytochemicals.
Yokoyama R +3 more
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Cheminformatics Identification and Validation of Dipeptidyl Peptidase-IV Modulators from Shikimate Pathway-Derived Phenolic Acids towards Interventive Type-2 Diabetes Therapy. [PDF]
Metabolites, 2022 Recently, dipeptidyl peptidase-IV (DPP-IV) has become an effective target in the management of type-2 diabetes mellitus (T2D). The study aimed to determine the efficacy of shikimate pathway-derived phenolic acids as potential DPP-IV modulators in the ...
Balogun FO +4 more
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Yarrowia lipolytica chassis strains engineered to produce aromatic amino acids via the shikimate pathway. [PDF]
Microb Biotechnol, 2021 Yarrowia lipolytica is widely used as a microbial producer of lipids and lipid derivatives. Here, we exploited this yeast’s potential to generate aromatic amino acids by developing chassis strains optimized for the production of phenylalanine, tyrosine ...
Larroude M, Nicaud JM, Rossignol T.
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Functional characterization of two 3-dehydroquinases of AroQ1 and AroQ2 in the shikimate pathway and expression of genes for the type III secretion system in Ralstonia solanacearum [PDF]
Frontiers in Microbiology, 2023 The shikimate pathway is a general route for the biosynthesis of aromatic amino acids (AAAs) in many microorganisms. A 3-dehydroquinase, AroQ, controls the third step of the shikimate pathway that catalyzes the formation of 3-dehydroquinate from 3 ...
Qingshan Zhang +6 more
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Structural and Biochemical Analyses Reveal that Chlorogenic Acid Inhibits the Shikimate Pathway. [PDF]
J Bacteriol, 2020 The shikimate pathway is an attractive target for the development of herbicides and antimicrobial agents, as it is essential in plants, bacteria, and apicomplexan parasites but absent in humans.
Neetu N +5 more
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BIOMASS YIELD 1 regulates sorghum biomass and grain yield via the shikimate pathway. [PDF]
J Exp Bot, 2020 BIOMASS YIELD 1 encodes a 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) that affects sorghum biomass and grain yield through regulation of primary and secondary metabolism via the shikimate pathway.
Chen J +8 more
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