Results 21 to 30 of about 2,926,592 (211)
SKPDB: a structural database of shikimate pathway enzymes [PDF]
BMC Bioinformatics, 2010 Background The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design.
de Azevedo Walter F +7 more
doaj +4 more sources
Enhanced biosynthesis of arbutin by engineering shikimate pathway in Pseudomonas chlororaphis P3. [PDF]
Microb Cell Fact, 2018 BackgroundArbutin is a plant-derived glycoside with potential antioxidant, antibacterial and anti-inflammatory activities. Currently, it is mainly produced by plant extraction or enzymatic processes, which suffers from expensive processing cost and low ...
Wang S +5 more
europepmc +2 more sources
Diet-Related Metabolic Perturbations of Gut Microbial Shikimate Pathway-Tryptamine-tRNA Aminoacylation-Protein Synthesis in Human Health and Disease. [PDF]
Int J Tryptophan Res, 2019 Human gut bacterial Na(+)-transporting NADH:ubiquinone reductase (NQR) sequence is associated with Alzheimer disease (AD). Here, Alzheimer disease-associated sequence (ADAS) is further characterized in cultured spore-forming Clostridium sp.
Paley EL.
europepmc +2 more sources
Shikimate Metabolic Pathway Engineering in Corynebacterium glutamicum
Journal of Microbiology and Biotechnology, 2021 Shikimate is a key high-demand metabolite for synthesizing valuable antiviral drugs, such as the anti-influenza drug, oseltamivir (Tamiflu). Microbial-based strategies for shikimate production have been developed to overcome the unstable and expensive ...
E. Park +6 more
semanticscholar +4 more sources
Molecules, 2022 The shikimate pathway is a necessary pathway for the synthesis of aromatic compounds. The intermediate products of the shikimate pathway and its branching pathway have promising properties in many fields, especially in the pharmaceutical industry.
Sijia Wu +4 more
doaj +1 more source
Multiple Metabolic Engineering Strategies to Improve Shikimate Titer in Escherichia coli
Metabolites, 2023 Shikimate is a valuable chiral precursor for synthesizing oseltamivir (Tamiflu®) and other chemicals. High production of shikimate via microbial fermentation has attracted increasing attention to overcome the unstable and expensive supply of shikimate ...
Taidong Bo +6 more
doaj +1 more source
Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism. [PDF]
PLoS ONE, 2012 Shikimate kinase (SK), which catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid in the presence of ATP, is the enzyme in the fifth step of the shikimate pathway for biosynthesis of aromatic amino acids.
Wen-Chi Cheng +7 more
doaj +1 more source
Shikimate pathway in apicomplexan parasites [PDF]
Nature, 1999 The discovery of plastids in apicomplexan parasites1,3 raised the possibility that these organelles might harbour plastid-specific metabolic activities that could be blocked by therapeutic agents. Ideally, these agents would inhibit the parasites without harming their vertebrate hosts.
Patrick J. Keeling +5 more
openaire +3 more sources
Molecules, 2021 Methicillin-resistant Staphylococcus aureus (MRSA) is an important threat as it causes serious hospital and community acquired infections with deathly outcomes oftentimes, therefore, development of new treatments against this bacterium is a priority ...
Lluvia Rios-Soto +7 more
doaj +1 more source
Pathway-based screening strategy for multitarget inhibitors of diverse proteins in metabolic pathways. [PDF]
PLoS Computational Biology, 2013 Many virtual screening methods have been developed for identifying single-target inhibitors based on the strategy of "one-disease, one-target, one-drug".
Kai-Cheng Hsu +4 more
doaj +1 more source