Results 11 to 20 of about 428,429 (208)

Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Cell Reports, 2020
Summary: Secondary bacterial infections often complicate viral respiratory infections. We hypothesize that perturbation of the gut microbiota during influenza A virus (IAV) infection might favor respiratory bacterial superinfection.
Valentin Sencio, Adeline Barthelemy, Luciana P. Tavares, Marina G. Machado, Daphnée Soulard, Céline Cuinat, Celso Martins Queiroz-Junior, Marie-Louise Noordine, Sophie Salomé-Desnoulez, Lucie Deryuter, Benoit Foligné, Céline Wahl, Benoit Frisch, Angelica T. Vieira, Christophe Paget, Graeme Milligan, Trond Ulven, Isabelle Wolowczuk, Christelle Faveeuw, Ronan Le Goffic, Muriel Thomas, Stéphanie Ferreira, Mauro M. Teixeira, François Trottein   +23 more
doaj   +3 more sources

Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose

Frontiers in Cell and Developmental Biology, 2023
Aims: Gut-microbiome derived short-chain fatty acids exert anti-inflammatory effects and delay progression of kidney disease in diabetic nephropathy. The aim of this study was to examine the impact in vivo and in vitro of short-chain fatty acid treatment
Yan Jun Li, Yan Jun Li, Jin Ma, Yik Wen Loh, Steven J. Chadban, Steven J. Chadban, Steven J. Chadban, Huiling Wu, Huiling Wu, Huiling Wu   +9 more
doaj   +1 more source

Short-chain fatty acids in diseases

Cell Communication and Signaling, 2023
AbstractShort-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate transporters, such as monocarboxylate transporter 1 and sodium-coupled monocarboxylate transporter 1, which promote cellular metabolism. An increasing number
Dan Zhang, Yong-Ping Jian, Yu-Ning Zhang, Yao Li, Li-Ting Gu, Hui-Hui Sun, Ming-Di Liu, Hong-Lan Zhou, Yi-Shu Wang, Zhi-Xiang Xu   +9 more
openaire   +3 more sources

Exogenous Short Chain Fatty Acid Effects in APP/PS1 Mice

Frontiers in Neuroscience, 2022
Elucidating the impact of the gut microbiome on Alzheimer’s Disease (AD) is an area of intense interest. Short chain fatty acids (SCFAs) are major microbiota metabolites that have been implicated as a mediator of gut microbiome effects in the brain. Here,
Diana J. Zajac, Benjamin C. Shaw, David J. Braun, Stefan J. Green, Joshua M. Morganti, Steven Estus   +5 more
doaj   +1 more source

Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function

Critical Care Explorations, 2021
Objectives:. The intestinal microbiome can modulate immune function through production of microbial-derived short-chain fatty acids. We explored whether intestinal dysbiosis in children with sepsis leads to changes in microbial-derived short-chain fatty ...
Scott L. Weiss, MD, MSCE, Kyle Bittinger, PhD, Jung-Jin Lee, PhD, Elliot S. Friedman, PhD, Lisa M. Mattei, PhD, Kathryn Graham, BS, Donglan Zhang, BS, Jeny Bush, RNC, Fran Balamuth, MD, PhD, MSCE, Francis X. McGowan, Jr, MD, Frederic D. Bushman, PhD, Robert N. Baldassano, MD, Gary D. Wu, MD, Douglas C. Wallace, PhD, Ronald G. Collman, MD   +14 more
doaj   +1 more source

Short-Chain Fatty Acids [PDF]

, 2020
The relationship between diet and the diversity and function of the intestinal microbiomeand its importance for human health is currently the subject of many studies. The type and proportionof microorganisms found in the intestines can determine the energy balance of the host.
Paulina Markowiak-Kopeć, Katarzyna Śliżewska   +1 more
openaire   +1 more source

The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids. [PDF]

Cell
Mannochio-Russo H, Charron-Lamoureux V, van Faassen M, Lamichhane S, Gonçalves Nunes WD, Deleray V, Ayala AV, Tanaka Y, Patan A, Vittali K, Rajkumar P, El Abiead Y, Zhao HN, Gomes PWP, Mohanty I, Lee C, Sund A, Sharma M, Liu Y, Pattynama D, Walker GT, Norton GJ, Khatib L, Andalibi MS, Wang CX, Ellis RJ, Moore DJ, Iudicello JE, Franklin D, Letendre S, Chin L, Walker C, Renwick S, Zemlin J, Meehan MJ, Song X, Kasper D, Burcham Z, Kim JJ, Kadakia S, Raffatellu M, Bode L, Chu H, Zengler K, Wang M, Siegel D, Knight R, Dorrestein PC.   +47 more
europepmc   +2 more sources

Short-chain fatty acids [PDF]

, 2021
Global obesity rates are increasing more and more. Short-chain fatty acids, the end products of fermentation of indigestible carbohydrates by intestinal bacteria, can influence metabolism and therefore play a role in the development of obesity and diabetes.
openaire   +2 more sources

Distinct Effects of Short Chain Fatty Acids on Host Energy Balance and Fuel Homeostasis With Focus on Route of Administration and Host Species

Frontiers in Neuroscience, 2021
Accumulating evidence implicates gut-microbiota-derived metabolites as important regulators of host energy balance and fuel homeostasis, the underlying mechanisms are currently subject to intense research.
Dehuang Kong, Lidewij Schipper, Gertjan van Dijk   +2 more
doaj   +1 more source

Short-chain fatty acids in cancer pathogenesis

Cancer and Metastasis Reviews, 2023
AbstractCancer is a multi-step process that can be viewed as a cellular and immunological shift away from homeostasis in response to selected infectious agents, mutations, diet, and environmental carcinogens. Homeostasis, which contributes importantly to the definition of “health,” is maintained, in part by the production of short-chain fatty acids ...
Mark A. Feitelson, Alla Arzumanyan, Arvin Medhat, Ira Spector   +3 more
openaire   +2 more sources