Results 21 to 30 of about 222,833 (265)
Short Chain Fatty Acids and Colon Cancer [PDF]
The Journal of Nutrition, 2002 The development of intestinal cancer involves complex genetic and epigenetic alterations in the intestinal mucosa. The principal signaling pathway responsible for the initiation of tumor formation, the APC-beta-catenin-TCF4 pathway, regulates both cell proliferation and colonic cell differentiation, but many other intrinsic and extrinsic signals also ...
Leonard H, Augenlicht +6 more
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NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells
Cell Reports, 2019 Summary: Autophagy plays a critical role in the maintenance of immunological memory. However, the molecular mechanisms involved in autophagy-regulated effector memory formation in CD8+ T cells remain unclear. Here we show that deficiency in NIX-dependent
Shubhranshu S. Gupta +6 more
doaj +1 more source
npj Parkinson's Disease, 2021 Animal models indicate that butyrate might reduce motor symptoms in Parkinson’s disease. Some dietary fibers are butyrogenic, but in Parkinson’s disease patients their butyrate stimulating capacity is unknown.
Florence Baert +6 more
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Short-chain fatty acids in cancer pathogenesis
Cancer and Metastasis Reviews, 2023 AbstractCancer is a multi-step process that can be viewed as a cellular and immunological shift away from homeostasis in response to selected infectious agents, mutations, diet, and environmental carcinogens. Homeostasis, which contributes importantly to the definition of “health,” is maintained, in part by the production of short-chain fatty acids ...
Mark A. Feitelson +3 more
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Engineering fungal de novo fatty acid synthesis for short chain fatty acid production
Nature Communications, 2017 The production of short chain fatty acids by microorganisms has numerous industrial and biofuel applications. Here the authors reprogrammeS. cerevisiaefatty acid synthase with five mutations to produce C6- and C8-fatty acids and identify thioesterases ...
Jan Gajewski +4 more
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Regulation of Inflammation by Short Chain Fatty Acids [PDF]
Nutrients, 2011 The short chain fatty acids (SCFAs) acetate (C2), propionate (C3) and butyrate (C4) are the main metabolic products of anaerobic bacteria fermentation in the intestine. In addition to their important role as fuel for intestinal epithelial cells, SCFAs modulate different processes in the gastrointestinal (GI) tract such as electrolyte and water ...
Vinolo, Marco A.R. +3 more
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Regulation of short-chain fatty acid production [PDF]
Proceedings of the Nutrition Society, 2003 Short-chain fatty acid (SCFA) formation by intestinal bacteria is regulated by many different host, environmental, dietary and microbiological factors. In broad terms, however, substrate availability, bacterial species composition of the microbiota and intestinal transit time largely determine the amounts and types of SCFA that are produced in healthy ...
Sandra, Macfarlane, George T, Macfarlane
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BioTechniques, 2023 Butyrate and propionate represent two of three main short-chain fatty acids produced by the intestinal microbiota. In healthy populations, their levels are reportedly equimolar, whereas a deviation in their ratio has been observed in various diseased ...
Pranvera Hiseni +5 more
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De novo fatty acid synthesis and elongation of fatty acids by subcellular fractions of lung
Journal of Lipid Research, 1971 Fatty acid synthesis by subcellular fractions of rabbit lung was studied by measuring the incorporation of either radioactive acetyl coenzyme A or malonyl coenzyme A into long-chain fatty acids.
HARVEY SCHILLER, KLAUS BENSCH
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Frontiers in Physiology, 2023 Introduction: The microbiota–gut–brain axis plays an important role in the pathophysiology of autism spectrum disorder, but its specific mechanisms remain unclear.
Jiu-Gen Zhong +10 more
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