Results 61 to 70 of about 547,631 (352)

Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer

Nature Communications, 2021
Emerging data demonstrate that the activity of immune cells can be modulated by microbial molecules. Here, we show that the short-chain fatty acids (SCFAs) pentanoate and butyrate enhance the anti-tumor activity of cytotoxic T lymphocytes (CTLs) and ...
Maik Luu, Zeno Riester, Adrian Baldrich, Nicole Reichardt, S. Yuille, A. Busetti, M. Klein, Anne Wempe, Hanna Leister, H. Raifer, F. Picard, K. Muhammad, K. Ohl, Rossana Romero, Florence Fischer, C. Bauer, M. Huber, T. Gress, M. Lauth, Sophia Danhof, T. Bopp, T. Nerreter, I. Mulder, U. Steinhoff, M. Hudecek, A. Visekruna   +25 more
semanticscholar   +1 more source

Nuts, bolts and short-chain fatty acids [PDF]

Canadian Medical Association Journal, 2011
I recall precisely two lectures on nutrition in medical school. True, we heard physiology lectures on short-chain fatty acids, and our biochemistry professors encouraged us to remember the structures of the amino acids, but just how these things related to what a person should eat remained ...
openaire   +2 more sources

Dietary short chain fatty acids protect against type 1 diabetes [PDF]

, 2017
The short-chain fatty acids (SCFAs) acetate and butyrate, which are released from specialized diets by gut microbes, protect non-obese diabetic (NOD) mice against insulitis and slow the progression of ...
Wen, L, Wong, FS
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health [PDF]

, 2018
Purpose of this Review: This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.
Chambers, Edward S., Frost, Gary, Morrison, Douglas J., Preston, Tom   +3 more
core   +1 more source

Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation*

Journal of Biological Chemistry, 2003
Short chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are produced at high concentration by bacteria in the gut and subsequently released in the bloodstream.
E. Le Poul, Cécile Loison, S. Struyf, J. Springael, V. Lannoy, Marie-Eve Decobecq, S. Brézillon, V. Dupriez, G. Vassart, J. Van Damme, M. Parmentier, M. Detheux   +11 more
semanticscholar   +1 more source

Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids

Scientific Reports, 2023
Microglia play a vital role maintaining brain homeostasis but can also cause persistent neuroinflammation. Short-chain fatty acids (SCFAs) produced by the intestinal microbiota have been suggested to regulate microglia inflammation indirectly by ...
M. Caetano-Silva, L. Rund, N. Hutchinson, J. Woods, A. Steelman, Rodney W. Johnson   +5 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The Potential Effects of Short-Chain Fatty Acids on the Epigenetic Regulation of Innate Immune Memory

Challenges, 2020
The regulation of innate immunity is substantially more ‘plastic’ than previously appreciated. Innate immune memory (manifested through trained immunity and tolerance) is a recently described epigenetic phenomenon that is a model example, with broad ...
Raphael Watt, Kimberley Parkin, David Martino   +2 more
doaj   +1 more source

Supplementation of lactic acid bacteria has positive effects on the mucosal health of Atlantic salmon (Salmo salar) fed soybean meal

Aquaculture Reports, 2023
We investigated the ability of lactic acid bacteria, when added individually or in combination in feeds, to prevent soybean meal-induced enteritis in Atlantic salmon.
Nadanasabesan Nimalan, Solveig Lysfjord Sørensen, Adriána Fečkaninová, Jana Koščová, Dagmar Mudroňová, Soňa Gancarčíková, Ioannis N. Vatsos, Saraswathy Bisa, Viswanath Kiron, Mette Sørensen   +9 more
doaj   +1 more source