Results 21 to 30 of about 61,394 (249)

A Census of Tandemly Repeated Polymorphic Loci in Genic Regions Through the Comparative Integration of Human Genome Assemblies

Frontiers in Genetics, 2018
Polymorphic Tandem Repeat (PTR) is a common form of polymorphism in the human genome. A PTR consists in a variation found in an individual (or in a population) of the number of repeating units of a Tandem Repeat (TR) locus of the genome with respect to ...
Loredana M. Genovese, Filippo Geraci, Lucia Corrado, Eleonora Mangano, Romina D'Aurizio, Roberta Bordoni, Marco Severgnini, Giovanni Manzini, Giovanni Manzini, Gianluca De Bellis, Sandra D'Alfonso, Marco Pellegrini   +11 more
doaj   +1 more source

Mutation of human short tandem repeats [PDF]

Human Molecular Genetics, 1993
A total of 20,000 parent-offspring transfers of alleles were examined through the genotyping within 40 CEPH reference families of 28 short tandem repeat polymorphisms (STRPs) located on chromosome 19. Forty-seven initial mutation events were detected in the STRPs using DNA from transformed lymphoblastoid cell lines, but less than half (39%) could be ...
J L, Weber, C, Wong
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Applications of X-Chromosome Short Tandem Repeats for Human Identification: A Review

Journal of Tropical Life Science, 2023
The forensic DNA profiling technique has tremendously contributed to forensic human identification, an important aspect in forensic investigations.
Naji Arafat Mahat, Aedrianee Reeza Alwi, Faezah Mohd Salleh, Seri Mirianti Ishar, Mohammad Rahim Kamaluddin, Mohd Radzniwan A. Rashid   +5 more
doaj   +1 more source

Short tandem repeat polymorphism evolution in humans [PDF]

European Journal of Human Genetics, 1998
Forty-five dinucleotide short tandem repeat polymorphisms were typed in ten large samples of a globally distributed set of populations. Although these markers had been selected for high heterozygosity in European populations, we found them to be sufficiently informative for linkage analysis in non-Europeans.
F, Calafell, A, Shuster, W C, Speed, J R, Kidd, K K, Kidd   +4 more
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Relatively semi-conservative replication and a folded slippage model for short tandem repeats

BMC Genomics, 2020
Background The ubiquitous presence of short tandem repeats (STRs) in virtually all genomes implicates their functional relevance, while a widely-accepted definition of STR is yet to be established. Previous studies majorly focus on relatively longer STRs,
Hongxi Zhang, Douyue Li, Xiangyan Zhao, Saichao Pan, Xiaolong Wu, Shan Peng, Hanrou Huang, Ruixue Shi, Zhongyang Tan   +8 more
doaj   +1 more source

Retrospective cell lineage reconstruction in humans by using short tandem repeats

Cell Reports: Methods, 2021
Summary: Cell lineage analysis aims to uncover the developmental history of an organism back to its cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important insights into the cell lineages of animals.
Liming Tao, Ofir Raz, Zipora Marx, Manjusha S. Ghosh, Sandra Huber, Julia Greindl-Junghans, Tamir Biezuner, Shiran Amir, Lilach Milo, Rivka Adar, Ron Levy, Amos Onn, Noa Chapal-Ilani, Veronika Berman, Asaf Ben Arie, Guy Rom, Barak Oron, Ruth Halaban, Zbigniew T. Czyz, Melanie Werner-Klein, Christoph A. Klein, Ehud Shapiro   +21 more
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Condensin Promotes Position Effects within Tandem DNA Repeats via the RITS Complex

Cell Reports, 2016
Summary: Tandem repetitive DNA is highly abundant in eukaryotic genomes and contributes to transcription control and genome stability. However, how the individual sequences within tandem repeats behave remains largely unknown.
Haijin He, Shu Zhang, Danni Wang, Andreas Hochwagen, Fei Li   +4 more
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Profiling the Genome-Wide Landscape of Short Tandem Repeats by Long-Read Sequencing

Frontiers in Genetics, 2022
Background: Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple genetic diseases and the regulation of gene expression. Long-read sequencing (LRS) offers a potential solution to genome-wide STR analysis. However,
Zhenhua Liu, Guihu Zhao, Yuhui Xiao, Sheng Zeng, Yanchun Yuan, Xun Zhou, Zhenghuan Fang, Runcheng He, Bin Li, Yuwen Zhao, Hongxu Pan, Yige Wang, Guoliang Yu, I-Feng Peng, Depeng Wang, Qingtuan Meng, Qian Xu, Qiying Sun, Xinxiang Yan, Lu Shen, Lu Shen, Hong Jiang, Hong Jiang, Kun Xia, Junling Wang, Jifeng Guo, Fan Liang, Jinchen Li, Jinchen Li, Jinchen Li, Beisha Tang, Beisha Tang, Beisha Tang, Beisha Tang   +33 more
doaj   +1 more source

The challenge of small-scale repeats for indel discovery

Frontiers in Bioengineering and Biotechnology, 2015
Repetitive sequences are abundant in the human genome. Different classes of repetitive DNA sequences, including simple repeats, tandem repeats, segmental duplications, interspersed repeats and other elements, collectively span more than 50% of the genome.
Giuseppe eNarzisi, Michael C Schatz
doaj   +1 more source

Inferring short tandem repeat variation from paired-end short reads [PDF]

Nucleic Acids Research, 2013
The advances of high-throughput sequencing offer an unprecedented opportunity to study genetic variation. This is challenged by the difficulty of resolving variant calls in repetitive DNA regions. We present a Bayesian method to estimate repeat-length variation from paired-end sequence read data.
Cao, Minh Duc, Tasker, Edward, Willadsen, Kai, Imelfort, Michael, Vishwanathan, Sailaja, Sureshkumar, Sridevi, Balasubramanian, Sureshkumar, Bodén, Mikael   +7 more
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