Results 21 to 30 of about 234,936 (321)

Core promoter short tandem repeats as evolutionary switch codes for primate speciation [PDF]

American Journal of Primatology, 2015
Alteration in gene expression levels underlies many of the phenotypic differences across species. Because of their highly mutable nature, proximity to the +1 transcription start site (TSS), and the emerging evidence of functional impact on gene ...
M. Ohadi, E. Valipour, Saeed Ghadimi-Haddadan, Pegah Namdar-Aligoodarzi, A. Bagheri, A. Kowsari, M. Rezazadeh, H. Darvish, S. Kazeminasab   +8 more
semanticscholar   +3 more sources

Modification of Huntington's disease by short tandem repeats. [PDF]

Brain Commun
Abstract Expansions of glutamine-coding CAG trinucleotide repeats cause a number of neurodegenerative diseases, including Huntington’s disease and several of spinocerebellar ataxias. In general, age-at-onset of the polyglutamine diseases is inversely correlated with the size of the respective inherited expanded CAG repeat.
Hong EP, Ramos EM, Aziz NA, Massey TH, McAllister B, Lobanov S, Jones L, Holmans P, Kwak S, Orth M, Ciosi M, Lomeikaite V, Monckton DG, Long JD, Lucente D, Wheeler VC, Gillis T, MacDonald ME, Sequeiros J, Gusella JF, Lee JM.   +20 more
europepmc   +4 more sources

Global abundance of short tandem repeats is non-random in rodents and primates [PDF]

BMC Genomic Data, 2022
Background While of predominant abundance across vertebrate genomes and significant biological implications, the relevance of short tandem repeats (STRs) (also known as microsatellites) to speciation remains largely elusive and attributed to random ...
Masoud Arabfard, Mahmood Salesi, Yazdan Hassani Nourian, Iman Arabipour, AliMohammad Ali Maddi, Kaveh Kavousi, Mina Ohadi   +6 more
doaj   +2 more sources

Author Correction: Short tandem repeats delineate gene bodies across eukaryotes [PDF]

Nature Communications
William B. Reinar, Anders K. Krabberød, Vilde O. Lalun, Melinka A. Butenko, Kjetill S. Jakobsen   +4 more
doaj   +2 more sources

Functional and Immunological Relevance of Anaplasma marginale Major Surface Protein 1a Sequence and Structural Analysis. [PDF]

, 2013
Bovine anaplasmosis is caused by cattle infection with the tick-borne bacterium, Anaplasma marginale. The major surface protein 1a (MSP1a) has been used as a genetic marker for identifying A.
Cabezas-Cruz, Alejandro, de la Fuente, José, Estrada-Peña, Agustín, Ferrolho, Joana, Grubhoffer, Libor, Kenneil, Rachel, Kocan, Katherine M., Lis, Katarzyna, Passos, Lygia M. F., Pohl, Anna E., Ribeiro, Mucio F. B., Shkap, Varda, Tonk, Miray, Valdés, James J., Zweygarth, Erich   +14 more
core   +21 more sources

Short tandem repeats bind transcription factors to tune eukaryotic gene expression

bioRxiv, 2022
Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and their polymorphisms alter gene expression, yet how they regulate transcription remains unknown. We find that STRs can modulate transcription factor (TF)-DNA affinities and
Connor A. Horton, Amr M. Alexandari, Michael G. B. Hayes, E. Marklund, Julia M. Schaepe, A. Aditham, Nilay Shah, Avanti Shrikumar, Ariel Afek, W. Greenleaf, Raluca Gordân, J. Zeitlinger, Anshul B Kundaje, P. Fordyce   +13 more
semanticscholar   +1 more source

Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species

Journal of Evolutionary Biology, 2022
Short tandem repeats (STRs) are units of 1–6 bp that repeat in a tandem fashion in DNA. Along with single nucleotide polymorphisms and large structural variations, they are among the major genomic variants underlying genetic, and likely phenotypic ...
M. Verbiest, Mikhail Maksimov, Yeong-ook Jin, M. Anisimova, M. Gymrek, Tugce Bilgin Sonay   +5 more
semanticscholar   +1 more source

DeepRepeat: direct quantification of short tandem repeats on signal data from nanopore sequencing

Genome Biology, 2022
Despite recent improvements in basecalling accuracy, nanopore sequencing still has higher error rates on short-tandem repeats (STRs). Instead of using basecalled reads, we developed DeepRepeat which converts ionic current signals into red-green-blue ...
Li Fang, Qian Liu, A. M. Monteys, P. Gonzalez-Alegre, B. Davidson, Kai Wang   +5 more
semanticscholar   +1 more source

DNA Fingerprinting: Use of Autosomal Short Tandem Repeats in Forensic DNA Typing

Cureus, 2022
Short tandem repeat (STR) markers for autosomal STR are used in forensic deoxyribonucleic acid (DNA) typing to track down the missing, verify family connections, and potentially connect suspects to crime sites.
Akshunna Keerti, Sudhir Ninave
semanticscholar   +1 more source

STRipy: A graphical application for enhanced genotyping of pathogenic short tandem repeats in sequencing data

bioRxiv, 2021
Short tandem repeats (STRs) are highly polymorphic with high mutation rates and expansions of STRs have been implicated as the causal variant in diseases.
A. Halman, E. Dolzhenko, A. Oshlack
semanticscholar   +1 more source