Results 41 to 50 of about 65,971 (285)
Urological Science, 2023 Purpose: The purpose of this study was to demonstrate the usefulness of genetic analysis with short tandem repeats (STRs) to identify the cellular origin of an unusual allograft urothelial carcinoma (UC).
Jia-Yuh Sheu +4 more
doaj +1 more source
Primers and Short Tandem Repeats genomic position.
, 2015 Primers and Short Tandem Repeats genomic position.
Pierre Hainaut (15065) +7 more
core +1 more source
lobSTR: A Short Tandem Repeat Profiler for Personal Genomes [PDF]
Genome Research, 2012 Short tandem repeats (STRs) have a wide range of applications, including medical genetics, forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to profile hundreds of thousands of STR loci. However, mainstream bioinformatics pipelines are inadequate for the task.
Melissa Gymrek +3 more
openaire +2 more sources
The challenge of small-scale repeats for indel discovery
Frontiers in Bioengineering and Biotechnology, 2015 Repetitive sequences are abundant in the human genome. Different classes of repetitive DNA sequences, including simple repeats, tandem repeats, segmental duplications, interspersed repeats and other elements, collectively span more than 50% of the genome.
Giuseppe eNarzisi, Michael C Schatz
doaj +1 more source
Systematic profiling of short tandem repeats in the cattle genome [PDF]
Genome Biology and Evolution, 2016 Short tandem repeats (STRs), or microsatellites, are genetic variants with repetitive 2–6 base pair motifs in many mammalian genomes. Using high-throughput sequencing and experimental validations, we systematically profiled STRs in five Holsteins.
Xu, Lingyang +10 more
openaire +2 more sources
Unexpected Properties of Short Genomic Tandem Repeats
, 2017 Length polymorphisms in genomic short tandem repeats have been implicated in a variety of diseases, most notably human neurodegenerative disorders. Expansions of tandem repeats are also associated with genomic instability in cancer. Our previous study of
Simon Kasif +3 more
core +1 more source
Short Tandem Repeats (STR) in cattle genomics and breeding [PDF]
Biotechnology in Animal Husbandry, 2018 Molecular markers are essential tool for determining the specific genetic makeup of an individual and are valuable approach for genetic improvement of farm animals.
Teneva Atanaska +7 more
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Link between short tandem repeats and translation initiation site selection
Human Genomics, 2018 Background Despite their vast biological implication, the relevance of short tandem repeats (STRs)/microsatellites to the protein-coding gene translation initiation sites (TISs) remains largely unknown.
Masoud Arabfard +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source