Results 31 to 40 of about 63,042 (246)

Genetic investigation of the origin of an allograft ureteral carcinoma with short tandem repeats: From recipient or donor?

Urological Science, 2023
Purpose: The purpose of this study was to demonstrate the usefulness of genetic analysis with short tandem repeats (STRs) to identify the cellular origin of an unusual allograft urothelial carcinoma (UC).
Jia-Yuh Sheu, Jeff Shih-Chieh Chueh, Chao-Yuan Huang, Hsiao-Lin Hwa, Shuo-Meng Wang   +4 more
doaj   +1 more source

Retrospective cell lineage reconstruction in humans by using short tandem repeats

Cell Reports: Methods, 2021
Summary: Cell lineage analysis aims to uncover the developmental history of an organism back to its cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important insights into the cell lineages of animals.
Liming Tao, Ofir Raz, Zipora Marx, Manjusha S. Ghosh, Sandra Huber, Julia Greindl-Junghans, Tamir Biezuner, Shiran Amir, Lilach Milo, Rivka Adar, Ron Levy, Amos Onn, Noa Chapal-Ilani, Veronika Berman, Asaf Ben Arie, Guy Rom, Barak Oron, Ruth Halaban, Zbigniew T. Czyz, Melanie Werner-Klein, Christoph A. Klein, Ehud Shapiro   +21 more
doaj   +1 more source

The challenge of small-scale repeats for indel discovery

Frontiers in Bioengineering and Biotechnology, 2015
Repetitive sequences are abundant in the human genome. Different classes of repetitive DNA sequences, including simple repeats, tandem repeats, segmental duplications, interspersed repeats and other elements, collectively span more than 50% of the genome.
Giuseppe eNarzisi, Michael C Schatz
doaj   +1 more source

Short tandem repeat polymorphism evolution in humans [PDF]

European Journal of Human Genetics, 1998
Forty-five dinucleotide short tandem repeat polymorphisms were typed in ten large samples of a globally distributed set of populations. Although these markers had been selected for high heterozygosity in European populations, we found them to be sufficiently informative for linkage analysis in non-Europeans.
F, Calafell, A, Shuster, W C, Speed, J R, Kidd, K K, Kidd   +4 more
openaire   +2 more sources

Short Tandem Repeats (STR) in cattle genomics and breeding [PDF]

Biotechnology in Animal Husbandry, 2018
Molecular markers are essential tool for determining the specific genetic makeup of an individual and are valuable approach for genetic improvement of farm animals.
Teneva Atanaska, Todorovska Elena, Petrović Milan P., Kusza Szilvia, Perriassamy Kathiravan, Caro-Petrović Violeta, Ostojić-Andrić Dušica, Gadjev Dimitar   +7 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Link between short tandem repeats and translation initiation site selection

Human Genomics, 2018
Background Despite their vast biological implication, the relevance of short tandem repeats (STRs)/microsatellites to the protein-coding gene translation initiation sites (TISs) remains largely unknown.
Masoud Arabfard, Kaveh Kavousi, Ahmad Delbari, Mina Ohadi   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Comprehensive Insights Into Forensic Features and Genetic Background of Chinese Northwest Hui Group Using Six Distinct Categories of 231 Molecular Markers

Frontiers in Genetics, 2021
The Hui minority is predominantly composed of Chinese-speaking Islamic adherents distributed throughout China, of which the individuals are mainly concentrated in Northwest China.
Chong Chen, Chong Chen, Xiaoye Jin, Xingru Zhang, Xingru Zhang, Wenqing Zhang, Yuxin Guo, Ruiyang Tao, Anqi Chen, Anqi Chen, Qiannan Xu, Qiannan Xu, Min Li, Min Li, Yue Yang, Yue Yang, Bofeng Zhu, Bofeng Zhu, Bofeng Zhu   +18 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source