Sialic Acids as Receptors for Pathogens. [PDF]
Biomolecules, 2021 Carbohydrates have long been known to mediate intracellular interactions, whether within one organism or between different organisms. Sialic acids (Sias) are carbohydrates that usually occupy the terminal positions in longer carbohydrate chains, which ...
Burzyńska P +4 more
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Sialometabolism in Brain Health and Alzheimer’s Disease [PDF]
Frontiers in Neuroscience, 2022 Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are mostly found as terminal residues in glycan structures of glycoconjugates including both glycoproteins and glycolipids.
Rawal, Punam, Zhao, Liqin
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Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer. [PDF]
J Immunother Cancer, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Despite the successful application of immune checkpoint blockade in a range of human cancers, immunotherapy in PDAC remains unsuccessful.
Boelaars K +16 more
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Journal of Biological Chemistry, 1966 Sialic acid 9-phosphate synthetase, an enzyme that condenses phosphoenolpyruvate with N-acyl- d -mannosamine 6-phosphate to yield sialic acid 9-phosphate and inorganic phosphate, was purified approximately 800-fold from extracts of hog submaxillary gland. The enzyme was specific for the indicated substrates, and the available data suggest that a single
George W. Jourdian +2 more
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Sialic Acids and Their Influence on Human NK Cell Function. [PDF]
Cells, 2021 Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing
Rosenstock P, Kaufmann T.
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α2,3-Linked Sialic Acids Are the Potential Attachment Receptor for Shaan Virus Infection in MARC-145 Cells. [PDF]
Microbiol Spectr, 2022 Shaan virus (ShaV), a novel species of the genus Jeilongvirus, family Paramyxoviridae, was isolated from an insectivore bat (Miniopterus schreibersii) in Korea in 2016.
Jang SS +5 more
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An enhanced dual detection of DMB-labeled sialic acids using high-resolution accurate mass spectrometry and fluorescence detection. [PDF]
BBA AdvSialic acids are important glycan components not only in the conformation of the structure but also in functions of many biological activities. Detection methods for sialic acid have been developed, and fluorescent labeling of sialic acids with 1,2 ...
Omoto T +7 more
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Biological Functions and Analytical Strategies of Sialic Acids in Tumor. [PDF]
Cells, 2020 Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface.
Zhou X, Yang G, Guan F.
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Intramolecular Lactones of Sialic Acids. [PDF]
Int J Mol Sci, 2020 The so-called “sialo-chemical-biology” has become an attractive research area, as an increasing number of natural products containing a sialic acid moiety have been shown to play important roles in biological, pathological, and immunological processes.
Rota P +4 more
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Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein. [PDF]
Front Chem, 2021 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still an emergent pandemic for humans. The virus infection is achieved by penetrating its spike protein to host cells via binding with ACE2.
Li B +11 more
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