Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Despite the successful application of immune checkpoint blockade in a range of human cancers, immunotherapy in PDAC remains unsuccessful.
Manfred Wuhrer +16 more
doaj +2 more sources
The Emerging Role of Sialic Acids in Obesity and Diabetes: Molecular Mechanisms and Therapeutic Perspectives [PDF]
BiomoleculesSialic acids are terminal monosaccharides that cap glycans on glycoconjugates. Accumulating clinical and experimental evidence shows that obesity, insulin resistance, and diabetes are accompanied by changes in sialic-acid levels. In these conditions, the
Xinyi Peng +4 more
doaj +2 more sources
Sialic Acids and Their Influence on Human NK Cell Function [PDF]
Cells, 2021 Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing
Philip Rosenstock, Thomas Kaufmann
doaj +2 more sources
Analysis on the terahertz spectral characteristics of two types of sialic acids in solid state and aqueous solution [PDF]
Scientific ReportsIn this study, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) were chosen as representative sialic acids to study their terahertz (THz) spectral characteristics in solid and aqueous states.
Zhuang Peng +6 more
doaj +2 more sources
An enhanced dual detection of DMB-labeled sialic acids using high-resolution accurate mass spectrometry and fluorescence detection [PDF]
BBA AdvancesSialic acids are important glycan components not only in the conformation of the structure but also in functions of many biological activities. Detection methods for sialic acid have been developed, and fluorescent labeling of sialic acids with 1,2 ...
Takayuki Omoto +7 more
doaj +2 more sources
α2,3-Linked Sialic Acids Are the Potential Attachment Receptor for Shaan Virus Infection in MARC-145 Cells [PDF]
Microbiology Spectrum, 2022 Shaan virus (ShaV), a novel species of the genus Jeilongvirus, family Paramyxoviridae, was isolated from an insectivore bat (Miniopterus schreibersii) in Korea in 2016.
Seong Sik Jang +5 more
doaj +2 more sources
Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections [PDF]
mBioPorcine epidemic diarrhea virus (PEDV) is a globally distributed alphacoronavirus with economic importance that can cause severe watery diarrhea and even death in piglets.
Guanghao Guo +12 more
doaj +2 more sources
Intramolecular Lactones of Sialic Acids. [PDF]
Int J Mol Sci, 2020 The so-called “sialo-chemical-biology” has become an attractive research area, as an increasing number of natural products containing a sialic acid moiety have been shown to play important roles in biological, pathological, and immunological processes.
Rota P +4 more
europepmc +5 more sources
Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein [PDF]
Frontiers in Chemistry, 2021 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still an emergent pandemic for humans. The virus infection is achieved by penetrating its spike protein to host cells via binding with ACE2.
Bingqian Li +12 more
doaj +2 more sources
Sialometabolism in Brain Health and Alzheimer’s Disease
Frontiers in Neuroscience, 2021 Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are mostly found as terminal residues in glycan structures of glycoconjugates including both glycoproteins and glycolipids.
Punam Rawal, Liqin Zhao, Liqin Zhao
doaj +1 more source