Sialic Acids and Their Influence on Human NK Cell Function [PDF]
Cells, 2021 Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing
Philip Rosenstock, Thomas Kaufmann
doaj +3 more sources
Biological Functions and Analytical Strategies of Sialic Acids in Tumor [PDF]
Cells, 2020 Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface.
Xiaoman Zhou, Ganglong Yang, Feng Guan
doaj +3 more sources
Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:Leishmania donovani, belonging to a unicellular protozoan parasite, display the differential level of linkage-specific sialic acids on their surface.
Saptarshi Roy, Chitra Mandal
doaj +2 more sources
Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Despite the successful application of immune checkpoint blockade in a range of human cancers, immunotherapy in PDAC remains unsuccessful.
Manfred Wuhrer +16 more
doaj +2 more sources
The role of cell surface sialic acids for SARS-CoV-2 infection. [PDF]
Glycobiology, 2021 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a new virus that has higher contagious capacity than any other previous human coronaviruses (HCoVs) and causes the current coronavirus disease 2019 pandemic. Sialic acids are a group of nine-
Sun XL.
europepmc +2 more sources
An enhanced dual detection of DMB-labeled sialic acids using high-resolution accurate mass spectrometry and fluorescence detection [PDF]
BBA AdvancesSialic acids are important glycan components not only in the conformation of the structure but also in functions of many biological activities. Detection methods for sialic acid have been developed, and fluorescent labeling of sialic acids with 1,2 ...
Takayuki Omoto +7 more
doaj +2 more sources
α2,3-Linked Sialic Acids Are the Potential Attachment Receptor for Shaan Virus Infection in MARC-145 Cells [PDF]
Microbiology Spectrum, 2022 Shaan virus (ShaV), a novel species of the genus Jeilongvirus, family Paramyxoviridae, was isolated from an insectivore bat (Miniopterus schreibersii) in Korea in 2016.
Seong Sik Jang +5 more
doaj +2 more sources
Gut Microbes, 2021 Gut microbiome composition depends heavily upon diet and has strong ties to human health. Dietary carbohydrates shape the gut microbiome by providing a potent nutrient source for particular microbes.
Joanna K Coker +3 more
doaj +2 more sources
Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses
Viruses, 2022 Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2,3 and α-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species ...
Chuankuo Zhao, Juan Pu
doaj +2 more sources
Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections [PDF]
mBioPorcine epidemic diarrhea virus (PEDV) is a globally distributed alphacoronavirus with economic importance that can cause severe watery diarrhea and even death in piglets.
Guanghao Guo +12 more
doaj +2 more sources