Sialic Acids and Their Influence on Human NK Cell Function
Cells, 2021 Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing
Thomas Kaufmann, Philip Rosenstock
exaly +4 more sources
Intramolecular Lactones of Sialic Acids. [PDF]
Int J Mol Sci, 2020 The so-called “sialo-chemical-biology” has become an attractive research area, as an increasing number of natural products containing a sialic acid moiety have been shown to play important roles in biological, pathological, and immunological processes.
Rota P +4 more
europepmc +7 more sources
Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Despite the successful application of immune checkpoint blockade in a range of human cancers, immunotherapy in PDAC remains unsuccessful.
Manfred Wuhrer +16 more
doaj +2 more sources
The Emerging Role of Sialic Acids in Obesity and Diabetes: Molecular Mechanisms and Therapeutic Perspectives [PDF]
BiomoleculesSialic acids are terminal monosaccharides that cap glycans on glycoconjugates. Accumulating clinical and experimental evidence shows that obesity, insulin resistance, and diabetes are accompanied by changes in sialic-acid levels. In these conditions, the
Xinyi Peng +4 more
doaj +2 more sources
Sialic acids in gastropods [PDF]
FEBS Letters, 2001 The occurrence of N‐acetylneuraminic acid and N‐glycolylneuraminic acid residues in preparations of the slug Arion lusitanicus (Gastropoda) was determined by sodium dodecyl sulphate electrophoresis of the proteins followed by lectin blots stained with the sialic acid specific lectin from Maackia amurensis, by the sensitivity of this binding to ...
Bürgmayr, Sabine +2 more
openaire +4 more sources
Sialic Acids in Kidney Disease: Immune Regulation, Complement Activation and Glomerular Injury [PDF]
AntioxidantsOxidative stress and inflammation are key drivers of kidney injury and disease progression. In this context, the role of sialic acids emerged as a critical regulatory layer linking redox imbalance, immune activation, and tissue damage.
Agnese Spennacchio +9 more
doaj +2 more sources
Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:Leishmania donovani, belonging to a unicellular protozoan parasite, display the differential level of linkage-specific sialic acids on their surface.
Chitra Mandal, Saptarshi Roy
exaly +2 more sources
Analysis on the terahertz spectral characteristics of two types of sialic acids in solid state and aqueous solution [PDF]
Scientific ReportsIn this study, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) were chosen as representative sialic acids to study their terahertz (THz) spectral characteristics in solid and aqueous states.
Zhuang Peng +6 more
doaj +2 more sources
An enhanced dual detection of DMB-labeled sialic acids using high-resolution accurate mass spectrometry and fluorescence detection [PDF]
BBA AdvancesSialic acids are important glycan components not only in the conformation of the structure but also in functions of many biological activities. Detection methods for sialic acid have been developed, and fluorescent labeling of sialic acids with 1,2 ...
Takayuki Omoto +7 more
doaj +2 more sources
Biological Functions and Analytical Strategies of Sialic Acids in Tumor
Cells, 2020 Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface.
Xiaoman Zhou, Ganglong Yang, Feng Guan
doaj +2 more sources