Results 41 to 50 of about 863,961 (270)

Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses

Viruses, 2022
Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2,3 and α-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species ...
Chuankuo Zhao, Juan Pu
doaj   +1 more source

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. [PDF]

PLoS ONE, 2011
Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low levels of cell surface-expressed CD4. Although HIV-1 infections are defined by viral tropisms according to chemokine receptor usage (R5 and X4 ...
Zhongcheng Zou, Ashley Chastain, Susan Moir, Jennifer Ford, Kathryn Trandem, Elena Martinelli, Claudia Cicala, Paul Crocker, James Arthos, Peter D Sun   +9 more
doaj   +1 more source

Relationship between plasma sialic acid and fibinogen concentration and incident micro-and macrovascular complications in type 1 diabetes [PDF]

, 2008
AIMS/HYPOTHESIS: Type 1 diabetes is associated with an increased risk of vascular complications. This increased risk could be explained by sialic acid and/or fibrinogen.
MICCOLI, ROBERTO, Pickup, J C, SOEDAMAH MUTHU SS, S. S. Soedamah-Muthu, J. H. Fuller, Chaturvedi, N, On behalf of EURODIAB PCS STUDY GROUP, CHATURVEDI N, Pickup, J.C., Fuller, J.H., Fuller, J H, FULLER JH, N. Chaturvedi, null null, PICKUP JC, J. C. Pickup, Soedamah-Muthu, S.S., Soedamah-Muthu, S S, Chaturvedi, N.   +18 more
core   +1 more source

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

Frontiers in Cellular and Infection Microbiology, 2019
The most frequent form of hemolytic-uremic syndrome (HUS) is associated with infections caused by Shiga-like toxin-producing Enterohaemorrhagic Escherichia coli (STEC). In rarer cases HUS can be triggered by Streptococcus pneumoniae.
Shahan Syed, Pipsa Hakala, Anirudh K. Singh, Anirudh K. Singh, Helena A. K. Lapatto, Samantha J. King, Samantha J. King, Seppo Meri, T. Sakari Jokiranta, T. Sakari Jokiranta, Karita Haapasalo   +10 more
doaj   +1 more source

Glycosidation of sialic acid.

Journal of Synthetic Organic Chemistry, Japan, 1989
N-Acetylneuraminic acid (Neu5Ac), a typical sialic acid, located at the non-reducing ends of carbohydrate chains of glycoproteins and glycolipids plays an important role in biological phenomena. The synthesis of oligosaccharides which contain Neu5Ac has focused with clarification of their vital functions.
OKAMOTO, Kaoru, GOTO, Toshio
openaire   +2 more sources

ANALYSIS OF SIALIC ACIDS IN BOVINE INTESTINAL MUCINS [PDF]

, 1984
Molecular species of sialic acids released by mild acid hydrolysis from mucins of bovine small and large intestine were characterized by two dimensional thin layer chromatography and gas chromatography-mass spectrometry.
Masayo, NISHIURA
core   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

Frontiers in Chemistry, 2018
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid ...
Rachel A. North, Rachel A. North, Rachel A. North, Weixiao Y. Wahlgren, Weixiao Y. Wahlgren, Daniela M. Remus, Daniela M. Remus, Mariafrancesca Scalise, Sarah A. Kessans, Sarah A. Kessans, Elin Dunevall, Elin Claesson, Tatiana P. Soares da Costa, Matthew A. Perugini, S. Ramaswamy, Jane R. Allison, Jane R. Allison, Jane R. Allison, Cesare Indiveri, Rosmarie Friemann, Rosmarie Friemann, Renwick C. J. Dobson, Renwick C. J. Dobson   +22 more
doaj   +1 more source

Siglecs as Therapeutic Targets in Cancer

Biology, 2021
Hypersialylation is a common post-translational modification of protein and lipids found on cancer cell surfaces, which participate in cell-cell interactions and in the regulation of immune responses. Sialic acids are a family of nine-carbon α-keto acids
Jackwee Lim, Duygu Sari-Ak, Tanaya Bagga
doaj   +1 more source

Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor [PDF]

, 2015
This research was supported by the University of St Andrews and grants provided by the Medical Research Council.Background: Streptococcus pneumoniae Neuraminidase A (NanA) is a multi-domain protein anchored to the bacterial surface.
Helen Connaris, Yang, Lei, Garry L. Taylor, Taylor, Garry Lindsay, Lei Yang, Potter, Jane Alexandra, Connaris, Helen, Jane A. Potter   +7 more
core   +1 more source