Results 41 to 50 of about 70,786 (313)

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

Frontiers in Cellular and Infection Microbiology, 2019
The most frequent form of hemolytic-uremic syndrome (HUS) is associated with infections caused by Shiga-like toxin-producing Enterohaemorrhagic Escherichia coli (STEC). In rarer cases HUS can be triggered by Streptococcus pneumoniae.
Shahan Syed, Pipsa Hakala, Anirudh K. Singh, Anirudh K. Singh, Helena A. K. Lapatto, Samantha J. King, Samantha J. King, Seppo Meri, T. Sakari Jokiranta, T. Sakari Jokiranta, Karita Haapasalo   +10 more
doaj   +1 more source

Siglecs as Therapeutic Targets in Cancer

Biology, 2021
Hypersialylation is a common post-translational modification of protein and lipids found on cancer cell surfaces, which participate in cell-cell interactions and in the regulation of immune responses. Sialic acids are a family of nine-carbon α-keto acids
Jackwee Lim, Duygu Sari-Ak, Tanaya Bagga
doaj   +1 more source

Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]

, 2019
The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B, Li, Qiongyu, Wong, Maurice, Xie, Yixuan   +3 more
core   +2 more sources

Sialic acid O-acetylation patterns and glycosidic linkage type determination by ion mobility-mass spectrometry

Nature Communications, 2023
O-acetylation is a common modification of sialic acids that has been implicated in a multitude of biological and disease processes. A lack of analytical methods that can determine exact structures of sialic acid variants is a hurdle to determine roles of
Gaёl M. Vos, Kevin C. Hooijschuur, Zeshi Li, John Fjeldsted, Christian Klein, Robert P. de Vries, Javier Sastre Toraño, Geert-Jan Boons   +7 more
doaj   +1 more source

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

Frontiers in Chemistry, 2018
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid ...
Rachel A. North, Rachel A. North, Rachel A. North, Weixiao Y. Wahlgren, Weixiao Y. Wahlgren, Daniela M. Remus, Daniela M. Remus, Mariafrancesca Scalise, Sarah A. Kessans, Sarah A. Kessans, Elin Dunevall, Elin Claesson, Tatiana P. Soares da Costa, Matthew A. Perugini, S. Ramaswamy, Jane R. Allison, Jane R. Allison, Jane R. Allison, Cesare Indiveri, Rosmarie Friemann, Rosmarie Friemann, Renwick C. J. Dobson, Renwick C. J. Dobson   +22 more
doaj   +1 more source

Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition [PDF]

, 2013
The recognition of sialic acids by two strains of minute virus of mice (MVM), MVMp (prototype) and MVMi (immunosuppressive), is an essential requirement for successful infection.
Agbandje-McKenna, M, Chen, X, Cotmore, S, Cummings, RD, Dell, A, Halder, S, Haslam, SM, Heimburg-Molinaro, J, McKenna, R, North, SJ, Smith, DF, Tattersall, P, Trollope, AJ   +12 more
core   +1 more source

Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. [PDF]

, 2016
Trypanosoma cruzi, the flagellate protozoan agent of Chagas disease or American trypanosomiasis, is unable to synthesize sialic acids de novo. Mucins and trans-sialidase (TS) are substrate and enzyme, respectively, of the glycobiological system that ...
A Acosta-Serrano, A Buschiazzo, A Egner, A Galetovic, Andrés B. Lantos, AS Couto, BB Diaz-Rohrer, Beatriz Araoz, CA Buscaglia, CA Buscaglia, Carlos A. Buscaglia, Carolyn R. Bertozzi, DC Bartholomeu, E Bayer-Santos, EJ Finkelsztein, G Bernabo, Giannina Carlevaro, GM Rocha, GM Rocha, GT Dempsey, H Yu, Hai Yu, HT McMahon, HT McMahon, I Levental, I Urban, IA Oliveira, IC Almeida, IC Almeida, J Folling, J Zimmerberg, JA Prescher, JA Prescher, JC Jewett, JH Lumb, JM Baskin, JM Di Noia, JM Di Noia, Juan Mucci, K Simons, KM Tyler, LM De Pablos, LM Freitas, M Hashimoto, Malcolm J. McConville, Mariano Bossi, María de los Milagros Camara, MdL Camara, ME Giorgi, MF Goncalves, MG Risso, ML Salto, MM Camargo, MS Leguizamón, MV Gudheti, NM Quanquin, NW Andrews, Oscar Campetella, P Ruiz Diaz, Pablo Ruiz Diaz, PN Ulrich, RE Thompson, RM de Lederkremer, RP Muiá, S Niyogi, S Schenkman, S Schenkman, S Schenkman, S Tomlinson, SS Rubin de Celis, T Furuya, TJ Gould, Torrecilhas AC Trocoli, U Frevert, V de Paulo Martins, V Jimenez, VA Campo, Vde P Martins, VL Pereira-Chioccola, W de Souza, W de Souza, WB Huttner, X Xu, Xi Chen   +83 more
core   +9 more sources

Cellular and Molecular Engineering of Glycan Sialylation in Heterologous Systems

Molecules, 2021
Glycans have been shown to play a key role in many biological processes, such as signal transduction, immunogenicity, and disease progression. Among the various glycosylation modifications found on cell surfaces and in biomolecules, sialylation is ...
Ryoma Hombu, Sriram Neelamegham, Sheldon Park   +2 more
doaj   +1 more source

The mucin-degradation strategy of Ruminococcus gnavus:The importance of intramolecular trans-sialidases [PDF]

, 2016
We previously identified and characterized an intramolecular trans-sialidase (IT-sialidase) in the gut symbiont Ruminococcus gnavus ATCC 29149, which is associated to the ability of the strain to grow on mucins. In this work we have obtained and analyzed
Crossman, Lisa C., Crost, Emmanuelle H, Henrissat, Bernard, Juge, Nathalie, Monestier, Marie, Swarbreck, David, Tailford, Louise E   +6 more
core   +2 more sources

Histochemical localization of sialic acids and antimicrobial substances in eccrine glands of porcine snout skin

European Journal of Histochemistry, 2012
The distribution of sialic acids and antimicrobial products (lysozyme, IgA, lactoferrin, β-defensin 2) as well as Rab3D in the eccrine glands of porcine snout skin was studied by sialoglycoconjugate histochemistry and immunohistochemistry.
K. Fukui, T. Yasui, H. Gomi, H. Sugiya, O. Fujimori, W. Meyer, A. Tsukise   +6 more
doaj   +1 more source