Sialic Acids as Receptors for Pathogens [PDF]
Biomolecules, 2021 Carbohydrates have long been known to mediate intracellular interactions, whether within one organism or between different organisms. Sialic acids (Sias) are carbohydrates that usually occupy the terminal positions in longer carbohydrate chains, which ...
Patrycja Burzyńska +4 more
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Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Despite the successful application of immune checkpoint blockade in a range of human cancers, immunotherapy in PDAC remains unsuccessful.
Manfred Wuhrer +16 more
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Sialic Acids and Their Influence on Human NK Cell Function [PDF]
Cells, 2021 Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing
Philip Rosenstock, Thomas Kaufmann
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An enhanced dual detection of DMB-labeled sialic acids using high-resolution accurate mass spectrometry and fluorescence detection [PDF]
BBA AdvancesSialic acids are important glycan components not only in the conformation of the structure but also in functions of many biological activities. Detection methods for sialic acid have been developed, and fluorescent labeling of sialic acids with 1,2 ...
Takayuki Omoto +7 more
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α2,3-Linked Sialic Acids Are the Potential Attachment Receptor for Shaan Virus Infection in MARC-145 Cells [PDF]
Microbiology Spectrum, 2022 Shaan virus (ShaV), a novel species of the genus Jeilongvirus, family Paramyxoviridae, was isolated from an insectivore bat (Miniopterus schreibersii) in Korea in 2016.
Seong Sik Jang +5 more
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Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections [PDF]
mBioPorcine epidemic diarrhea virus (PEDV) is a globally distributed alphacoronavirus with economic importance that can cause severe watery diarrhea and even death in piglets.
Guanghao Guo +12 more
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Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein [PDF]
Frontiers in Chemistry, 2021 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still an emergent pandemic for humans. The virus infection is achieved by penetrating its spike protein to host cells via binding with ACE2.
Bingqian Li +12 more
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Journal of Biological Chemistry, 1966 Sialic acid 9-phosphate synthetase, an enzyme that condenses phosphoenolpyruvate with N-acyl- d -mannosamine 6-phosphate to yield sialic acid 9-phosphate and inorganic phosphate, was purified approximately 800-fold from extracts of hog submaxillary gland. The enzyme was specific for the indicated substrates, and the available data suggest that a single
W. Kündig, Sudhamoy Ghosh, Saul Roseman
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The Biosynthesis of Sialic Acids
Journal of Biological Chemistry, 1962 Leonard Warren, Herbert Felsenfeld
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Sialometabolism in Brain Health and Alzheimer’s Disease
Frontiers in Neuroscience, 2021 Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are mostly found as terminal residues in glycan structures of glycoconjugates including both glycoproteins and glycolipids.
Punam Rawal, Liqin Zhao, Liqin Zhao
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