Results 11 to 20 of about 5,067,072 (323)
Sialic Acids as Receptors for Pathogens [PDF]
Biomolecules, 2021 Carbohydrates have long been known to mediate intracellular interactions, whether within one organism or between different organisms. Sialic acids (Sias) are carbohydrates that usually occupy the terminal positions in longer carbohydrate chains, which ...
Patrycja Burzyńska +4 more
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Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. [PDF]
PLoS ONE, 2011 Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low levels of cell surface-expressed CD4. Although HIV-1 infections are defined by viral tropisms according to chemokine receptor usage (R5 and X4 ...
Zhongcheng Zou +9 more
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Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein [PDF]
Frontiers in Chemistry, 2021 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still an emergent pandemic for humans. The virus infection is achieved by penetrating its spike protein to host cells via binding with ACE2.
Bingqian Li +12 more
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The Biosynthesis of Sialic Acids
Journal of Biological Chemistry, 1962 Leonard Warren, Herbert Felsenfeld
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Journal of Biological Chemistry, 1966 Sialic acid 9-phosphate synthetase, an enzyme that condenses phosphoenolpyruvate with N-acyl- d -mannosamine 6-phosphate to yield sialic acid 9-phosphate and inorganic phosphate, was purified approximately 800-fold from extracts of hog submaxillary gland. The enzyme was specific for the indicated substrates, and the available data suggest that a single
W. Kündig, Sudhamoy Ghosh, Saul Roseman
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Nature Communications, 2021 Changes in glycosylation during tumour progression are a key hallmark of cancer. One of the glycan moieties generally overexpressed in cancer are sialic acids, which can induce immunomodulatory properties via binding to Siglec receptors.
Ernesto Rodriguez +15 more
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Sialometabolism in Brain Health and Alzheimer’s Disease
Frontiers in Neuroscience, 2021 Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are mostly found as terminal residues in glycan structures of glycoconjugates including both glycoproteins and glycolipids.
Punam Rawal, Liqin Zhao, Liqin Zhao
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Intramolecular Lactones of Sialic Acids. [PDF]
Int J Mol Sci, 2020 The so-called “sialo-chemical-biology” has become an attractive research area, as an increasing number of natural products containing a sialic acid moiety have been shown to play important roles in biological, pathological, and immunological processes.
Rota P +4 more
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Sialic acids in gastropods [PDF]
FEBS Letters, 2001 The occurrence of N‐acetylneuraminic acid and N‐glycolylneuraminic acid residues in preparations of the slug Arion lusitanicus (Gastropoda) was determined by sodium dodecyl sulphate electrophoresis of the proteins followed by lectin blots stained with the sialic acid specific lectin from Maackia amurensis, by the sensitivity of this binding to ...
Sabine Bürgmayr +2 more
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Determination of sialic acids in the nervous system of silkworm (Bombyx mori L.): Effects of aging and development [PDF]
Archives of Biological Sciences, 2017 Sialic acids mainly occur as components on cell surface glycoproteins and glycolipids. They play a major role in the chemical and biological diversity of glycoconjugates. Although sialic acids exhibit great structural variability in vertebrates,
Soya Seçkin +3 more
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