Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:Leishmania donovani, belonging to a unicellular protozoan parasite, display the differential level of linkage-specific sialic acids on their surface.
Saptarshi Roy, Chitra Mandal
doaj +1 more source
Advances in Nutrition, 2012 Early postnatal development encounters milk as a key environmental variable and yet the sole nutrient source. One evolutionary conserved constituent of milk is sialic acid, which is generally displayed on glycoconjugates and free glycans. During early postnatal development, high sialic acid need was proposed to be unmet by the endogenous sialic acid ...
Norbert, Sprenger, Peter I, Duncan
openaire +2 more sources
Polymer-stabilized sialylated nanoparticles : synthesis, optimization, and differential binding to influenza hemagglutinins [PDF]
, 2020 During influenza infection, hemagglutinins (HAs) on the viral surface bind to sialic acids on the host cell's surface. While all HAs bind sialic acids, human influenza targets terminal α2,6 sialic acids and avian influenza targets α2,3 sialic acids.
Baker, Alexander +3 more
core +2 more sources
Biological Functions and Analytical Strategies of Sialic Acids in Tumor
Cells, 2020 Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface.
Xiaoman Zhou, Ganglong Yang, Feng Guan
doaj +1 more source
Determination of sialic acids in the nervous system of silkworm (Bombyx mori L.): Effects of aging and development [PDF]
Archives of Biological Sciences, 2017 Sialic acids mainly occur as components on cell surface glycoproteins and glycolipids. They play a major role in the chemical and biological diversity of glycoconjugates. Although sialic acids exhibit great structural variability in vertebrates,
Soya Seçkin +3 more
doaj +1 more source
Synthesis of Sialic Acids and Sialic Acid Derivatives [PDF]
, 1982 Sialic acids as such, sialic acid derivatives, analogues, glycosides and sialooligosaccharides have been subject of many synthetic investigations. These studies were aimed at a further exploration of the properties of sialic acids, the preparation of substrates and inhibitors for sialidases, sialyltransferases or for sialic acid converting enzymes, and
Vliegenthart, J.F.G., Kamerling, J.P.
openaire +2 more sources
Sialic Acids: An Important Family of Carbohydrates Overlooked in Environmental Biofilms
Applied Sciences, 2020 Sialic acids in the structural matrix of biofilms developing in engineered water systems constitute a potential target in the battle against biofouling.
Ingrid S.M. Pinel +5 more
doaj +1 more source
Sialic acid acquisition in bacteria - one substrate many transporters [PDF]
, 2016 The sialic acids are a family of 9-carbon sugar acids found predominantly on the cell-surface glycans of humans and other animals within the Deuterostomes and are also used in the biology of a wide range of bacteria that often live in association with ...
Thomas, Gavin Hugh
core +1 more source
Sialic acids: An Avenue to Target Cancer Progression, Metastasis, and Resistance to Therapy
Forum of Clinical Oncology, 2022 Sialic acids are alpha-keto acids with nine carbons that are commonly present in the terminal sugars of glycans on glycoproteins and glycolipids on the cell surface.
Goni Mallikarjun +3 more
doaj +1 more source
mBio, 2021 All cells in vertebrates are coated with a dense array of glycans often capped with sugars called sialic acids. Sialic acids have many functions, including serving as a signal for recognition of “self” cells by the immune system, thereby guiding an ...
Sudeshna Saha +15 more
doaj +1 more source