Sialic acids: An Avenue to Target Cancer Progression, Metastasis, and Resistance to Therapy
Forum of Clinical Oncology, 2022 Sialic acids are alpha-keto acids with nine carbons that are commonly present in the terminal sugars of glycans on glycoproteins and glycolipids on the cell surface.
Goni Mallikarjun +3 more
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Screening coronavirus and human proteins for sialic acid binding sites using a docking approach
AIMS Biophysics, 2021 The initial step of interaction of some pathogens with the host is driven by the interaction of glycoproteins of either side via endcaps of their glycans. These end caps consist of sialic acids or sugar molecules.
Chia-Wen Wang +2 more
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Sialic acid acquisition in bacteria - one substrate many transporters [PDF]
, 2016 The sialic acids are a family of 9-carbon sugar acids found predominantly on the cell-surface glycans of humans and other animals within the Deuterostomes and are also used in the biology of a wide range of bacteria that often live in association with ...
Thomas, Gavin Hugh
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Synthesis of Sialic Acids and Sialic Acid Derivatives [PDF]
, 1982 Sialic acids as such, sialic acid derivatives, analogues, glycosides and sialooligosaccharides have been subject of many synthetic investigations. These studies were aimed at a further exploration of the properties of sialic acids, the preparation of substrates and inhibitors for sialidases, sialyltransferases or for sialic acid converting enzymes, and
Vliegenthart, J.F.G., Kamerling, J.P.
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Distribution of Sialic Acids on Mucins and Gels: A Defense Mechanism [PDF]
, 2012 Moist mucosal epithelial interfaces that are exposed to external environments are dominated by sugar epitopes, some of which (e.g., sialic acids) are involved in host defense.
Baos, S.C. +4 more
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In-Silico evidence for two receptors based strategy of SARS-CoV-2 [PDF]
Front. Mol. Biosci., 09 June 2021, 2020 We propose a novel numerical method able to determine efficiently and effectively the relationship of complementarity between portions of proteins surfaces. This innovative and general procedure, based on the representation of the molecular iso-electron density surface in terms of 2D Zernike polynomials, allows the rapid and quantitative assessment of ...
arxiv +1 more source
Free and bound forms of sialic acid in blood plasma of patients with chronic lymphocytic leukemia
Regulatory Mechanisms in Biosystems, 2015 The level of free and bound forms of sialic acids (SА) was investigated in chronic lymphocytic leukemia (CLL) and at different stages of receiving chemotherapy.
O. V. Netronina
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Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection
mBio, 2020 Coronaviruses (CoVs) are common human and animal pathogens that can transmit zoonotically and cause severe respiratory disease syndromes. CoV infection requires spike proteins, which bind viruses to host cell receptors and catalyze virus-cell membrane ...
Enya Qing +3 more
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Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids. [PDF]
PLoS ONE, 2011 Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low levels of cell surface-expressed CD4. Although HIV-1 infections are defined by viral tropisms according to chemokine receptor usage (R5 and X4 ...
Zhongcheng Zou +9 more
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Influence of Host Sialic Acid Receptors Structure on the Host Specificity of Influenza Viruses
Viruses, 2022 Influenza viruses need to use sialic acid receptors to invade host cells, and the α-2,3 and α-2,6 sialic acids glycosidic bonds linking the terminal sialic acids are generally considered to be the most important factors influencing the cross-species ...
Chuankuo Zhao, Juan Pu
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