Results 31 to 40 of about 70,452 (316)
Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin [PDF]
Front Mol Biosci. 2021; 8: 607443, 2020 Despite the huge effort to contain the infection, the novel SARS-CoV-2 coronavirus has rapidly become pandemics, mainly due to its extremely high human-to-human transmission capability, and a surprisingly high viral charge of symptom-less people. While the seek of a vaccine is still ongoing, promising results have been obtained with antiviral compounds.
arxiv +1 more source
Sialic acid and crystal binding [PDF]
Kidney International, 2000 We studied the role of cell surface sialic acid in the adherence of calcium oxalate monohydrate (COM) crystals to Madin-Darby canine kidney (MDCK) cells.Studies were performed with undifferentiated (crystal-binding) cells in subconfluent cultures and maturated (noncrystal-binding) cells in confluent cultures.
Burt G. van der Boom +3 more
openaire +4 more sources
Diversity in the sialic acids [PDF]
Glycobiology, 1992 Historical background It is now more than 50 years since N-acetyl-neuraminic acid was first discovered and subsequently characterized by several groups (reviewed in Roseman, 1970; Gottschalk, 1972; Rosenberg and Schengrund, 1976; Schauer, 1982; Faillard, 1989).
openaire +4 more sources
Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus. [PDF]
, 2017 Sialic acids (Sias) are important glycans displayed on the cells and tissues of many different animals and are frequent targets for binding and modification by pathogens, including influenza viruses.
Ajit Varki +10 more
core +3 more sources
, 2021 Let us study viruses and the role of sialic acids in their first step of reproduction, the attachment to cells. We begin our study with the help of the "Earth's virology course", created by Vincent Racaniello, with David Tuller and Gertrud U. Rey. The first virus that we will study is that of influenza A. Actually, "Earth's virology course" is a proper
openaire +2 more sources
Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]
, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi +2 more
core +2 more sources
An orthologue of bacteroides fragilis NanH is the principal sialidase in tannerella forsythia [PDF]
, 2009 Sialidase activity is a putative virulence factor of the anaerobic periodontal pathogen Tannerella forsythia, but it is uncertain which genes encode this activity.
Booth, V. +4 more
core +3 more sources
Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood
Frontiers in Cellular and Infection Microbiology, 2019 The most frequent form of hemolytic-uremic syndrome (HUS) is associated with infections caused by Shiga-like toxin-producing Enterohaemorrhagic Escherichia coli (STEC). In rarer cases HUS can be triggered by Streptococcus pneumoniae.
Shahan Syed +10 more
doaj +1 more source
Siglecs as Therapeutic Targets in Cancer
Biology, 2021 Hypersialylation is a common post-translational modification of protein and lipids found on cancer cell surfaces, which participate in cell-cell interactions and in the regulation of immune responses. Sialic acids are a family of nine-carbon α-keto acids
Jackwee Lim, Duygu Sari-Ak, Tanaya Bagga
doaj +1 more source
The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity
Frontiers in Chemistry, 2018 Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic acid ...
Rachel A. North +22 more
doaj +1 more source