Results 51 to 60 of about 70,942 (317)

Spatiotemporal expression patterns of sialoglycoconjugates during nephron morphogenesis and their regional and cell type-specific distribution in adult rat kidney [PDF]

, 2018
The expression of α2,6- and α2,3-linked sialic acids on N-glycans was studied in embryonic, postnatal, and adult rat kidney. Histochemistry and blotting using Polyporus squamosus and Sambucus nigra lectins for α2,6-linked sialic acids and the Maackia ...
Goldstein, Irwin, Paulson, James, Roth, Jürgen, Toma, Valeriu, Winter, Harry, Zuber, Christian   +5 more
core  

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells [PDF]

, 2015
Sialic acids are negatively charged nine-carbon carboxylated monosaccharides that often cap glycans on glycosylated proteins and lipids. Because of their strategic location at the cell surface, sialic acids contribute to interactions that are critical ...
Hakan Kalay, Henrike Veninga, Janneke N. Samsom, Joke M. M. den Haan, Juan J. Garcia-Vallejo, Juan M. Ilarregui, Lenneke A. M. Cornelissen, Lisette A. van Berkel, Luciana Berod, Marleen I. Verstege, Martino Ambrosini, Maurizio Perdicchio, Paul R. Crocker, Sakaguchi, Sjoerd T. T. Schetters, Steef Engels, Tim Sparwasser, Wendy W. J. Unger, Yvette van Kooyk   +18 more
core   +4 more sources

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Sialic Acid Mutarotation Is Catalyzed by the Escherichia coli β-Propeller Protein YjhT [PDF]

, 2008
The acquisition of host-derived sialic acid is an important virulence factor for some bacterial pathogens, but in vivo this sugar acid is sequestered in sialoconjugates as the {alpha}-anomer.
Leech, Andrew, Müller, Axel, Potts, Jennifer R., Severi, Emmanuele, Thomas, Gavin H., Williamson, David, Wilson, Keith S.   +6 more
core   +1 more source

Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung [PDF]

, 2014
Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently been shown to function as a negative regulator of β2-integrin-dependent neutrophil recruitment to the lung following exposure to lipopolysaccharide (LPS).
Anderson, Boyle, Boyle, Chen, Chen, Doerschuk, Fisher, Franke, Gao, Grommes, Hoyal, Kielland, Kulkarni, Liu, Matthay, McMillan, Mócsai, Pollock, Segal, Segal, Segal, Zhang, Zhang, Zhang   +23 more
core   +3 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells

Cellular & Molecular Biology Letters
Background Small extracellular vesicles (sEV) are closely associated with the development and metastasis of many types of mammalian cancer. Glycoconjugates are highly expressed on sEV and play important roles in sEV biogenesis and their interaction with ...
Meixuan Lin, Xiaoqiang Xu, Xiaoman Zhou, Hui Feng, Ruili Wang, Yunyun Yang, Jing Li, Ning Fan, Yazhuo Jiang, Xiang Li, Feng Guan, Zengqi Tan   +11 more
doaj   +1 more source

Expanding the Reaction Space of Linkage-Specific Sialic Acid Derivatization

Molecules, 2019
The human glycome is characterized by a high degree of sialylation, affecting, amongst others, cell−cell interactions and protein half-life. An established method for the linkage isomer-specific characterization of N-glycan sialylation is based on ...
Tamas Pongracz, Manfred Wuhrer, Noortje de Haan   +2 more
doaj   +1 more source

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. [PDF]

, 2018
Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface.
Haigh, Nathan E, Lebrilla, Carlito B, Liu, Mingqi, Maverakis, Emanual, Park, Diane Dayoung, Phoomak, Chatchai, Wong, Maurice, Wongkham, Sopit, Xu, Gege, Yang, Pengyuan   +9 more
core  

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source