Results 61 to 70 of about 70,452 (316)

Increased Level of α2,6-Sialylated Glycans on HaCaT Cells Induced by Titanium Dioxide Nanoparticles under UV Radiation

open access: yesNanomaterials, 2018
As one of the most widely used nanomaterials, the safety of nano-TiO2 for human beings has raised concern in recent years. Sialylation is an important glycosylation modification that plays a critical role in signal transduction, apoptosis, and tumor ...
Yuanyuan Ren   +7 more
doaj   +1 more source

Sialidase NEU1 suppresses progression of human bladder cancer cells by inhibiting fibronectin-integrin α5β1 interaction and Akt signaling pathway

open access: yesCell Communication and Signaling, 2020
Background Sialic acids are widely distributed in animal tissues, and aberrantly expressed in a variety of cancer types. High expression of sialic acid contributes to tumor aggressiveness by promoting cell proliferation, migration, angiogenesis, and ...
Xiaoman Zhou   +9 more
doaj   +1 more source

Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]

open access: yesPLoS ONE, 2012
Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez   +6 more
doaj   +1 more source

Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling

open access: yesFrontiers in Molecular Biosciences, 2021
All cells are decorated with a highly dense and complex structure of glycan chains, which are mostly attached to proteins and lipids. In this context, sialic acids are a family of nine-carbon acidic monosaccharides typically found at the terminal ...
Cátia Oliveira Soares   +9 more
doaj   +1 more source

Sialic Acid Receptors of Viruses [PDF]

open access: yes, 2013
Sialic acid linked to glycoproteins and gangliosides is used by many viruses as a receptor for cell entry. These viruses include important human and animal pathogens, such as influenza, parainfluenza, mumps, corona, noro, rota, and DNA tumor viruses.
Georg Herrler   +2 more
openaire   +3 more sources

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

open access: yesFEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Spatiotemporal expression patterns of sialoglycoconjugates during nephron morphogenesis and their regional and cell type-specific distribution in adult rat kidney [PDF]

open access: yes, 2018
The expression of α2,6- and α2,3-linked sialic acids on N-glycans was studied in embryonic, postnatal, and adult rat kidney. Histochemistry and blotting using Polyporus squamosus and Sambucus nigra lectins for α2,6-linked sialic acids and the Maackia ...
Goldstein, Irwin   +5 more
core  

Glycomic analysis of high density lipoprotein shows a highly sialylated particle. [PDF]

open access: yes, 2014
Many of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL.
German, J Bruce   +6 more
core   +1 more source

Carbohydrates great and small, from dietary fiber to sialic acids: How glycans influence the gut microbiome and affect human health

open access: yesGut Microbes, 2021
Gut microbiome composition depends heavily upon diet and has strong ties to human health. Dietary carbohydrates shape the gut microbiome by providing a potent nutrient source for particular microbes.
Joanna K Coker   +3 more
doaj   +1 more source

Interfacial Yield Stress Response in Synthetic Mucin Solutions

open access: yesAdvanced Materials Interfaces, EarlyView.
The solution rheology of novel synthetic mucins mimicking natural mucin domains is studied. Like many natural mucin solutions, apparent solid‐like rheology is seen. However, no bulk structural features are found to explain it. Interfacial rheology and robust modelling reveal that this arises from molecular associations at the air–water interface ...
Sumit Sunil Kumar   +7 more
wiley   +1 more source

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