Results 61 to 70 of about 70,942 (317)

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Increased Level of α2,6-Sialylated Glycans on HaCaT Cells Induced by Titanium Dioxide Nanoparticles under UV Radiation

Nanomaterials, 2018
As one of the most widely used nanomaterials, the safety of nano-TiO2 for human beings has raised concern in recent years. Sialylation is an important glycosylation modification that plays a critical role in signal transduction, apoptosis, and tumor ...
Yuanyuan Ren, Xin Liu, Runqing Geng, Qunwei Lu, Rong Rao, Xi Tan, Xiangliang Yang, Wei Liu   +7 more
doaj   +1 more source

Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling

Frontiers in Molecular Biosciences, 2021
All cells are decorated with a highly dense and complex structure of glycan chains, which are mostly attached to proteins and lipids. In this context, sialic acids are a family of nine-carbon acidic monosaccharides typically found at the terminal ...
Cátia Oliveira Soares, Cátia Oliveira Soares, Ana Sofia Grosso, Ana Sofia Grosso, June Ereño-Orbea, June Ereño-Orbea, Helena Coelho, Helena Coelho, Filipa Marcelo, Filipa Marcelo   +9 more
doaj   +1 more source

Glycan analysis of the chicken synaptic plasma membrane glycoproteins - a major synaptic N-glycan carries the LewisX determinant [PDF]

, 2005
The majority of plasma membrane components are glycosylated. It is now widely accepted that this post-translational modification is crucial during the establishment, maintenance and function of the nervous system.
Koles, Kate, McDowell, William, Mileusnic, Radmila, Rose, Steven P.R.   +3 more
core   +4 more sources

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Sialidase NEU1 suppresses progression of human bladder cancer cells by inhibiting fibronectin-integrin α5β1 interaction and Akt signaling pathway

Cell Communication and Signaling, 2020
Background Sialic acids are widely distributed in animal tissues, and aberrantly expressed in a variety of cancer types. High expression of sialic acid contributes to tumor aggressiveness by promoting cell proliferation, migration, angiogenesis, and ...
Xiaoman Zhou, Yanhong Zhai, Changmei Liu, Ganglong Yang, Jia Guo, Guang Li, Chengwen Sun, Xiaowei Qi, Xiang Li, Feng Guan   +9 more
doaj   +1 more source

Specific synthesis of neurostatin and gangliosides O-acetylated in the outer sialic acids using a sialate transferase. [PDF]

PLoS ONE, 2012
Gangliosides are sialic acid containing glycosphingolipids, commonly found on the outer leaflet of the plasma membrane. O-acetylation of sialic acid hydroxyl groups is one of the most common modifications in gangliosides.
Lorenzo Romero-Ramírez, Isabel García-Álvarez, Ramón Campos-Olivas, Michel Gilbert, Marie-France Goneau, Alfonso Fernández-Mayoralas, Manuel Nieto-Sampedro   +6 more
doaj   +1 more source

Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. [PDF]

, 2019
Dietary habits have been associated with alterations of the human gut resident microorganisms contributing to obesity, diabetes and cancer1. In Western diets, red meat is a frequently eaten food2, but long-term consumption has been associated with ...
Alisson-Silva, Frederico, Chang, Geoffrey, Chuzel, Léa, Diaz, Sandra L, Ganatra, Mehul B, Huang, Jianbo, Martino, Cameron, Rees, Steven D, Secrest, Patrick, Siegel, Dionicio, Taron, Christopher H, Varki, Ajit, Zaramela, Livia S, Zengler, Karsten, Zuñiga, Cristal   +14 more
core  

Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]

, 2015
Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming, Gagneux, Pascal, Garcia, Javier O, Garcia-Bingman, Andrea, Glass, Christopher K, Hazen, Stanley L, Heyser, Charles, Lin, Hongqiao, Läubli, Heinz, Pearce, Oliver MT, Romanoski, Casey E, Samraj, Annie N, Schwarz, Flavio, Secrest, Patrick, Varki, Ajit, Varki, Nissi, Wang, Xiaoxia   +16 more
core   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source