Results 101 to 110 of about 46,454 (250)

Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling. [PDF]

Nat Commun, 2023
De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau É, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM.   +18 more
europepmc   +1 more source

Determinants of anemia and hemoglobin concentration in haitian school-aged children [PDF]

, 2015
Anemia diminishes oxygen transport in the body, resulting in potentially irreversible growth and developmental consequences for children. Limited evidence for determinants of anemia exists for school-aged children.
Brown, Sarah, Delnatus, Jacques R, Eaton, Jacob C, Griggs, Jennifer J, Iannotti, Lora L, Odom, Audrey R, Wolff, Patricia B   +6 more
core   +2 more sources

Sickling hemoglobin polymerization in iguana erythrocytes

Comparative Biochemistry and Physiology Part A: Physiology, 1982
Abstract 1. 1. Polymerized hemoglobin in the cytoplasm and nuclei of erythrocytes from iguana (Cyclura cornuta and Cyclura figgensi) form fibers like those of sickled cells in some mammals. 2. 2. Sickling is greater in C. cornuta than in C. figgensi and is promoted by O2 or N2 while pH has no effect. 3. 3.
College of Veterinary Medicine and College of Medicine, University of Florida, Box J-136 JHMHC, Gainesville, FL 32610, U.S.A. ( host institution ), Simpson, C.F ( author ), Taylor, W.J ( author ), Jacobson, E.R ( author )   +3 more
openaire   +3 more sources

Continuum of care after newborn screening for sickle cell disease: Multinational evidence from a systematic review and meta‐analysis

British Journal of Haematology, EarlyView.
Tanveer Rehman, Srijeeta Mitra, Kalpita Ganpat Gawit, Ravindra Kumar, Sritama Dutta, Ananya Anurakta Pattanaik, Lakhan Majhee, Tanu Anand, Manisha Madkaikar, Sanghamitra Pati   +9 more
wiley   +1 more source

Exploring the immunomodulatory impacts of blood manufacturing consolidation

Transfusion, EarlyView.
Abstract Introduction The immunomodulatory consequences of blood transfusion, known as transfusion‐related immune modulation (TRIM), are often not captured by hemovigilance systems. Changes to blood product manufacturing processes may impact patient outcomes.
Amanda Kauffman, Michelle P. Zeller, Yang Liu, Jason P. Acker, Donald M. Arnold, Nancy Heddle, Chris Hillis, Na Li, Bram Rochwerg, Kayla Lucier, Summer Syed, Shuoyan Ning   +11 more
wiley   +1 more source

Determining of the Hydroxyurea Effluence on TCD Parameters of Sickle Cell Patients

مجله دانشکده پزشکی اصفهان, 2009
Background: Sickle cell disease is the most common hemoglobinopathies that affect a specific intracellular protein named as hemoglobin. This disease has several clinical manifestations including, CNS involvement.
Nasser Sharafadinzadeh, Nastaran Majdinasb, Khodamorad Zandian, Keiwan Taherpoor, Armaghan Moravej Aleali, Mohamad Pipelzadeh   +5 more
doaj  

Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease. [PDF]

Biomacromolecules, 2022
Vunnam N, Hansen S, Williams DC, Been MO, Lo CH, Pandey AK, Paulson CN, Rohde JA, Thomas DD, Sachs JN, Wood DK.   +10 more
europepmc   +1 more source

Improving Communication between Doctors and Parents after Newborn Screening [PDF]

, 2011
Background: Newborn screening (NBS) enables early treatment, and some consider it a natural vehicle for genetic screening. Bioethicists argue for caution since families of infants with carrier status can develop psychosocial complications.
Christopher, Stephanie, Collins, Jenelle, Eskra, Kerry, Farrell, Michael, Farrell, Philip M., Hoffman, Gary, Kennedy-Parker, Karen, La Pean, Alison, Panepinto, Julie, Tluczek, Audrey   +9 more
core   +2 more sources

Safety and efficacy of blood exchange transfusion for priapism complicating sickle cell disease. [PDF]

, 2016
BACKGROUND: Priapism is unwanted painful penile erection that affects about 36% of boys and men with sickle cell disease (SCD) most of whom have sickle cell anemia. Clinically, priapism could be stuttering, minor, or major.
Adeyoju, Ayache, Ballas, Ballas, Baron, Betke, Charache, Eckman, Emond, Harms, Janes, Mantadakis, Okpala, Powars, Rackoff, Rogers, Seeler, Serjeant, Serjeant, Sharpsteen, Siegel, Talacki, Teixeira, US Department of Health and Human Services   +23 more
core   +2 more sources

Fetal hemoglobin in sickle cell anemia

Blood, 2011
AbstractFetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin polymer. Fetal hemoglobin genes are genetically regulated, and the level of HbF and its distribution among sickle erythrocytes is highly variable.
Idowu, Akinsheye, Abdulrahman, Alsultan, Nadia, Solovieff, Duyen, Ngo, Clinton T, Baldwin, Paola, Sebastiani, David H K, Chui, Martin H, Steinberg   +7 more
openaire   +3 more sources