Results 61 to 70 of about 46,454 (250)
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objectives This study evaluates the association of low‐dose aspirin (LDA) with hemoglobin (Hb) levels during pregnancy and explores how changes in Hb levels relate to hypertensive disorders of pregnancy (HDP). Methods This secondary analysis of a randomized controlled trial comprised 249 pregnant women recruited from a regional hospital in ...
N. M. Ngcobo +4 more
wiley +1 more source
Fetal hemoglobin in sickle cell anemia
Blood, 2020 AbstractFetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer prospects for curative therapy of sickle cell disease. This review focuses on (1) HbF quantitative trait loci and the geography of β-globin gene haplotypes, especially those found in the Middle East; (2) how HbF might differentially impact the ...
openaire +3 more sources
Unusual low sickle cell hemoglobin level
Haematologica, 2013 In the January 2013 issue of this Journal, Joly and Colleagues have described an unusual case of sickle cell trait.[1][1] The patient, originating from Ivory Coast, exhibits a low HbS level (12%) with no phenotypic manifestations.
Faouzi Baklouti, Jean Delaunay
openaire +3 more sources
Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress
iNew Medicine, EarlyView.ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai +7 more
wiley +1 more source
Screening for the Sickle Cell Trait in Odisha, India: An Approach to a Major Public Health Burden
Online Journal of Health & Allied Sciences, 2021 The present study aims to determine the prevalence and distribution of sickle cell traits in Koraput district of Odisha along with the financial burden on households. A total of 1092 individuals of either sex, aged above 30 years, were randomly screened.
Basanta Kumar Bindhani +3 more
doaj
Reaching Community Through School Going Children for Sickle Cell Disease in Zankhvav Village of Surat District, Western India [PDF]
, 2012 Objectives: The objective of the study was to explore a method to reach the community via school going adolescents for screening tribal people for Sickle Cell disease.
Bansal, R +4 more
core +1 more source
Comorbidity, Pain, Utilization, and Psychosocial Outcomes in Older versus Younger Sickle Cell Adults: The PiSCES Project [PDF]
, 2017 Background. Patients with SCD now usually live well into adulthood. Whereas transitions into adulthood are now often studied, little is published about aging beyond the transition period. We therefore studied age-associated SCD differences in utilization,
Aisiku, Imoigele P. +6 more
core +4 more sources
Prenatal Diagnosis, EarlyView.ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear +6 more
wiley +1 more source
Haematologica, 2016 Increased fetal hemoglobin levels lessen the severity of symptoms and increase the lifespan of patients with sickle cell disease. Hydroxyurea, the only drug currently approved for the treatment of sickle cell disease, is not effective in a large ...
Angela Rivers +9 more
doaj +1 more source