Results 131 to 140 of about 11,185,234 (160)

Siglec-15 dependent alteration of the leukemia immune microenvironment

Blood
Introduction: Relapsed and refractory hematologic malignancies remain a significant clinical challenge despite integration of newer therapeutic strategies engaging the immune system as standard of care.
Dailia B. Francis, Marina E. Michaud, Jodi Dougan, Miyoung Lee, Manoj K. Bhasin, Christopher Porter   +5 more
semanticscholar   +1 more source

Investigating the Role and Mechanism of Methionine in Different Types of Skeletal Fluorosis Based on Siglec-15 Methylation.

Environmental Pollution
Skeletal fluorosis has a complex pathogenic mechanism and diverse phenotypes, which mainly manifest as osteosclerosis, osteoporosis, and osteomalacia. Differences in nutrient levels exert a vital effect on skeletal fluorosis development.
Yu-Dan Liao, Congyu Yin, Niannian Chen, Lei Song, Xi-Lan Wang, Xue-Li Pan   +5 more
semanticscholar   +1 more source

Deciphering the Glycan and Protein Interactome of Siglec-15: Unraveling its Role in Tumor-Associated Immunosuppression 2949

Journal of Immunology
Immunotherapy has revolutionized cancer treatment, driving interest in strategies to counteract immune suppression within the tumor microenvironment. Siglec-15, a member of the sialic acid-binding immunoglobulin-like lectin family, has emerged as a
Nohelly Derosiers, William Aguilar, A. Posey   +2 more
semanticscholar   +1 more source

Screening and Preparation of Nanobodies for SIGLEC-15 Detection.

Protein Expression and Purification
As an important member of the Siglec family, SIGLEC-15 plays an important role in osteoclast differentiation, bone remodeling, and tumor immune evasion. In the tumor microenvironment, SIGLEC-15 functions independently of the B7-H1/PD-1 pathway.
Shuaiying Zhao, Lingyun Li, Zhongyun Lan, Xiangyun Hou, Ruimin Huang, Quanfang Jin, Qiting Huang, Li Jia, Yingying Kong, Jianchuan Wen, Hua-Rui Qiao, Yi'ang Wang, Yi-Wen Xu, Dongna Zhang, Yong Geng, Jian-Feng Xu, Yuan-Yuan Dai   +16 more
semanticscholar   +1 more source

TMIC-21. Dual blockade of Siglec-15 and PD-1, combined with oncolytic Zika virus therapy, confers protection against immune-resistant gliomas

Neuro-Oncology
The immunosuppressive tumor microenvironment is a major challenge in GBM. We are developing oncolytic Zika virus (ZIKV) as a treatment that targets treatment-resistant glioma stem cells and ignites CD8+ T-cell dependent anti-tumor immune response.
Ashwani Kesarwani, Sonam Verma, Amber Neil Griffith, Tong Hu, Fei Shu, Amanda Andrade de Costa, Y. Li, Mridu Kanga, Brett H Herzog, D. DeNardo, Mai T. Dang, Jingqin Luo, Pei-Yong Shi, Xuping Xie, Jun Wang, Lieping Chen, Albert Kim, Peggy L. Kendall, Michael S. Diamond, M. Chheda   +19 more
semanticscholar   +1 more source

Eupatilin suppresses osteoclastogenesis and periodontal bone loss by inhibiting the MAPKs/Siglec-15 pathway.

International Immunopharmacology
Periodontitis is a widely prevalent oral disease around the world characterized by the disruption of the periodontal ligament and the subsequent development of periodontal pockets, as well as the loss of alveolar bone, and may eventually lead to tooth ...
Boxuan Zhao, Zhiyong Chen, Ting Li, Han-Tao Yao, Zi-Jun Wang, Yilin Liao, Haiying Guo, Dong-jie Fu, Yaoting Ji, Min-Quan Du   +9 more
semanticscholar   +1 more source

Targeting Siglec-15 mediates mitochondrial retrograde regulation of cervical cancer development.

Tissue & Cell
Cervical cancer (CCA) is the predominant cause of fatalities from gynecologic malignancies, with metastasis responsible for 80 % of cancer-related mortalities.
Jing Wang, Zeng-Hui Li, Yi-Fan He, Yong-Li Chu   +3 more
semanticscholar   +1 more source

Abstract 1373: Gene expression correlation of immune checkpoint molecules Siglec-15 and PD-L1 varies widely by cancer indication

Cancer Research
Siglec-15 is a novel target for immunotherapy in cancer and exhibits low mRNA expression in normal tissues but broad expression across cancer indications, specifically on tumor-associated macrophages and tumor cells [1]. Expression of Siglec-15 and the
Krystal Watkins, Liyang Diao, Marsha Crochiere, Jan Pinkas   +3 more
semanticscholar   +1 more source

Siglec-15 expression in diffuse gliomas and its correlation with MRI morphologic features and apparent diffusion coefficient

Acta Radiologica
Background Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) enhances tumor immune escape and leads to tumor growth. Purpose To investigate the expression of Siglec-15 in diffuse gliomas and its correlation with tumor magnetic resonance ...
Quan Chen, Chunhua Wang, Yingqian Geng, Wan-Yi Zheng, Zhen Chen, Rifeng Jiang, Xiaomei Hu   +6 more
semanticscholar   +1 more source

Single-Cell Profiling of the Immune Response Following Siglec 15 Knockout in Leukemia Cells

Blood
Background: Siglec-15 (Sig15) has emerged as a putative immune checkpoint, highly expressed in several solid and hematological malignancies, including B cell acute lymphoblastic leukemia (B-ALL).
Marina E. Michaud, Jodi Dougan, Dailia B. Francis, Mojtaba Bakhtiari, Christopher C. Porter, Manoj K. Bhasin   +5 more
semanticscholar   +1 more source