Results 111 to 120 of about 11,185,234 (160)

Siglec-15 is a glyco-immune checkpoint in prostate cancer regulating immune evasion and metastasis

Prostate cancer is a leading cause of cancer-related mortality in men, and effective treatment options are limited for advanced and metastatic disease. The sialoglycan immune checkpoint Siglec-15 has emerged as a key mediator of tumour-associated immune ...
David B Sykes, Nicoll Matthews, Liancheng Lu, Richard Beatson, Matthew Fisher, Ziqian Peng, Ella P Dennis, Jennifer Munkley, Margarita Orozco-Moreno, Dallas B Flies, Feier Zeng, Libby Blencoe, Michelle A Lawson, Kirsty Hodgson, Shenglin Mei, Ning Wang   +15 more
core   +1 more source

Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapy

Molecular Cancer
T cell responses are generally curtailed by suppressive mechanisms within the tumor microenvironment (TME) that prevent T cell infiltration and function.
Rui M. L. Coelho, Reno Debets, Dora Hammerl   +2 more
doaj   +1 more source

Mechanisms of tumor immune escape mediated by Siglec-15 and advances and prospects in targeted therapy

Zhongguo aizheng zazhi
Immune checkpoint blockade targeting the programmed cell death protein-1 (PD-1) and its ligand PD-L1 has revolutionized cancer immunotherapy; however, a substantial proportion of patients exhibit primary or acquired resistance, underscoring the existence
WANG Shihui, ZHENG Tianqing
doaj  

Siglec-15 Expression in Gastric Carcinoma and Its Association With Clinicopathological Variables. [PDF]

World J Oncol
Al Badr S, Battah A, Alsughayer A, Alsmarat F, Halahleh K, Sughayer M.   +5 more
europepmc   +1 more source

Association between DPAGT1 and Siglec-15 expression and the malignant phenotype of hepatocellular carcinoma. [PDF]

Am J Cancer Res
Luo M, Wang X, Wang H, Liu Y, Huang C, Wei H.   +5 more
europepmc   +1 more source

Siglec-15 promotes a feed-forward loop between TNBC cells and macrophages via the NF-κB/DcR3/CCL18/STAT3 axis. [PDF]

Transl Oncol
Wang S, Wang HQ, Zhao H, Zhao R, Zhao P, Mu Q.   +5 more
europepmc   +1 more source

Siglec-15 Enhances Cisplatin Resistance in Cervical Cancer Cells by Promoting Mitochondrial Retrograde Signaling Through Activation of the MAPK Pathway

Chemoresistance constitutes a major cause of poor prognosis in advanced cervical cancer. Our previous studies have confirmed that Siglec-15 affects the progression of cervical cancer, whereas its role in regulating cervical cancer ...
Li Hao, Zenghui Li, Junwei Zhao, Jing Wang   +3 more
core   +1 more source

Siglec‑15 dysregulation and its therapeutic implications in new‑onset type 1 diabetes. [PDF]

Int J Mol Med
Guo H, Tao Y, Li S, Gu Y, Huang Y, Fang C, Hu J.   +6 more
europepmc   +1 more source

Quantitative assessment of Siglec-15 expression in lung, breast, head, and neck squamous cell carcinoma and bladder cancer. [PDF]

Lab Invest, 2022
Shafi S, Aung TN, Xirou V, Gavrielatou N, Vathiotis IA, Fernandez A, Moutafi M, Yaghoobi V, Herbst RS, Liu LN, Langermann S, Rimm DL.   +11 more
europepmc   +1 more source

Expression and function of Siglec-15 in RLPS and its correlation with PD-L1: Bioinformatics Analysis and Clinicopathological Evidence. [PDF]

Int J Med Sci, 2022
Cui L, Tian X, Yan L, Guan X, Dong B, Zhao M, Lv A, Liu D, Wu J, Hao C.   +9 more
europepmc   +1 more source