Results 91 to 100 of about 11,185,234 (160)

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

567 PYX-106, a highly differentiated anti-Siglec-15 monoclonal antibody, reverses Siglec-15 mediated immune suppression and enhances cytotoxic activity in human lymphocytes

Regular and Young Investigator Award Abstracts
Background Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a single-pass type I membrane glycoprotein that functions as an anti-tumor immune suppressor.
Anthony B. Rodriguez, Chuan Shen, Matthew Iovino, Chengfeng Merriman, Nicolas Sévère, Frank Wang, Jan Pinkas   +6 more
semanticscholar   +1 more source

Cholesterol 25‐Hydroxylase Deficiency Provides an Optimal and Durable Protective T Helper 1 Immunity via Interleukin‐12–Interleukin‐2 Axis in BCG‐Vaccinated Mice

MedComm, Volume 7, Issue 10, October 2026.
CH25H deficiency permits optimal dendritic cell activation following BCG exposure, characterized by increased IL‐12p70 production. In vivo, CH25H deficiency promotes enhanced BCG‐mediated protection and sustained IL‐2 producing T cell response. ABSTRACT Bacillus Calmette‐Guérin (BCG) remains the only licensed vaccine for tuberculosis (TB), yet its ...
Hagyu Kim, Eunsol Choi, Kee Woong Kwon, Hong‐Hee Choi, Kyungmin Kim, WeonSeok Jung, Sung Jae Shin   +6 more
wiley   +1 more source

Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus [PDF]

, 2014
Several bacterial pathogens decorate their surfaces with sialic acid (Sia) residues within cell wall components or capsular exopolysaccharides. Sialic acid expression can promote bacterial virulence by blocking complement activation or by engagement of ...
Joshua Olson, Louie, Aaron, Crocker, Paul R., Victor Nizet, Aaron Louie, Ajit Varki, Paul R. Crocker, Varki, Ajit, Nizet, Victor, Yung-Chi Chang, Chang, Yung-Chi, Olson, Joshua   +11 more
core   +1 more source

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation [PDF]

Tsukazaki H., Kikuta J., Ao T., et al. Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation.
Kikuta, Junichi, Tsuda, Eisuke, Minoshima, Masafumi, Ao, Tomoka, Fukuda, Chie, Ishii, Masaru, Kikuchi, Kazuya, Tsukazaki, Hiroyuki, Kaito, Takashi, Morimoto, Akito   +9 more
core   +2 more sources

Seminal Extracellular Vesicles as Molecular Modulators of Male Reproductive Function

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Extracellular vesicles (sEVs) contained in seminal plasma (SP) maintain, in concert with free SP‐components (proteins, hormones, cytokines, metabolites and antioxidants) under an endocrine umbrella the functional in vivo homeostasis of ejaculated spermatozoa. The sEVs define a generic mixture of nanovesicles delivered by male epithelial cells,
Heriberto Rodriguez‐Martinez, Jordi Roca, Fernando Peña Vega, Emilio A. Martinez   +3 more
wiley   +1 more source

Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey, Annkathrin Ratter, Finn Brigger, Louie Cielen, Pascal Kunz, Ea Tulin, Kinga Mikos, Lothar Dieterich, Marco D'Addio, Cornelia Halin, Richard D. Cummings, Vivianne I. Otto   +11 more
wiley   +1 more source

219 Associations of the immunomodulatory molecule Siglec-15 gene and protein expression to immune gene signatures as a potential biomarker for Siglec-15 targeted therapy in non-small cell lung cancer

Regular and Young Investigator Award Abstracts
Background Despite the recent success of immunotherapies against cancer, not all patients benefit from treatment. Biomarkers capable of predicting therapeutic response may improve patient selection and increase the number of patients that benefit from ...
Maira Soto, Krystal Watkins, Justin Trickett, Marsha Crochiere, Jan Pinkas   +4 more
semanticscholar   +1 more source

521 Characterization and prevalence of the novel immunomodulatory protein Siglec-15 expression in tumor cells and macrophages across multiple solid tumor indications

Regular and Young Investigator Award Abstracts
Background Siglec-15 is a member of the sialic acid-binding Ig-like lectins (Siglec) family and is a novel target for immunotherapy in cancer. It exhibits low expression in normal tissues but broad expression across cancer indications, specifically on ...
Krystal Watkins, Chuan Shen, Xiao-Dong F. Liu, Marsha Crochiere, Jan Pinkas   +4 more
semanticscholar   +1 more source