Results 81 to 90 of about 11,185,234 (160)

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

A Multidimensional Framework for Interpreting Macrophage Markers in the Era of Cellular Heterogeneity

Immunology, EarlyView.
Macrophage markers should be interpreted as context‐dependent biological readouts rather than deterministic cell identifiers. This Review proposes a multidimensional framework integrating lineage, identity, and functional state across complementary experimental modalities to enable a more accurate interpretation of macrophage heterogeneity.
Alessandro Palma
wiley   +1 more source

Siglec-9 blocking antibody decreases viral infectivity of the supernatants of co-cultures of NK and autologous HIV-infected primary CD4⁺ T cells.

, 2021
(A) A schematic representation of the workflow to evaluate the cytotoxic potential of NK cells against autologous HIV-infected CD4+ T cells in the presence of Siglec-9 antibody. CD4+ T cells were isolated from fresh PBMC and exposed to HIV-1 for 72 h. On
Han Xiao (373894), Opeyemi S. Adeniji (11682034), Ziyang Xu (1322553), Glen M. Chew (7122281), Costin Tomescu (606955), Ashley F. George (11682037), Mohamed Abdel-Mohsen (283492), Leticia Kuri-Cervantes (7382828), Chenfei Yu (1586326), Lishomwa C. Ndhlovu (7122293), David B. Weiner (9579320), Michelle Ho (6311882), Qin Liu (59805), Michael R. Betts (11682040), Nadia R. Roan (1320618), Kar Muthumani (504713), Cecilia Shikuma (22963)   +16 more
core   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Immune proteomic associations with indices of cortical development in 5‐year‐old children

Journal of Anatomy, EarlyView.
Typically developing 5‐year‐old children (n = 101–126) from the FinnBrain Birth Cohort Study, Finland, underwent both targeted serum immune proteomics and magnetic resonance brain imaging. Multiple inflammatory markers, from one cluster of co‐expressed immune proteins, were negatively associated with indices of cortical development, including thickness,
Aaron Barron, Aylin Rosberg, Jetro J. Tuulari, Minna Lukkarinen, Harri Merisaari, Eero Silver, Venla Kumpulainen, Anni Copeland, Ekaterina Saukko, Alex M. Dickens, Matej Oresic, Tuulia Hyötylainen, Linnea Karlsson, Hasse Karlsson, Isabella L. C. Mariani Wigley, Elmo P. Pulli   +15 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source

Tumor-associated carbohydrates and immunomodulatory lectins as targets for cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
During oncogenesis, tumor cells present specific carbohydrate chains that are new targets for cancer immunotherapy. Whereas these tumor-associated carbohydrates (TACA) can be targeted with antibodies and vaccination approaches, TACA including sialic acid-
Alfred Zippelius, Heinz Läubli, Natalia Rodrigues Mantuano, Marina Natoli   +3 more
doaj   +1 more source

The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?

Journal of Periodontal Research, EarlyView.
Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander, Huile Lim, Gilad Bachrach, Miguel Reis Ferreira   +3 more
wiley   +1 more source