Results 61 to 70 of about 11,185,234 (160)
Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment
Advanced Science, EarlyView.Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang +9 more
wiley +1 more source
Siglec-1 expression by MDMs is enhanced via IFN exposure and leads to VLP internalization.
, 2017 (A) Representative Siglec-1 and tetherin surface expression of GM-CSF matured MDMs together with 24 h IFN alpha stimulation (1000 U/ml). (B) Western blot of Siglec-1 and actin upon incubation with increasing amounts of IFN alpha in GM-CSF derived MDMs ...
Sarah Takushi (3699919) +7 more
core +1 more source
Cell ReportsSummary: Siglec-15 regulates osteoclast differentiation. The cellular pathways contributing to the expression of Siglec-15 ligand on osteoclast precursors are incompletely understood.
Huei-Syuan Jiang +3 more
doaj +1 more source
Siglecs as Therapeutic Targets in Cancer
Biology, 2021 Hypersialylation is a common post-translational modification of protein and lipids found on cancer cell surfaces, which participate in cell-cell interactions and in the regulation of immune responses. Sialic acids are a family of nine-carbon α-keto acids
Jackwee Lim, Duygu Sari-Ak, Tanaya Bagga
doaj +1 more source
Siglec-1 mediated phagocytosis of promastigotes in macrophages.
, 2016 (A) Sias-siglec dependent phagocytosis was quantitated by flow cytometry. J774A.1 (1× 106/well) cells were grown in a six well plate, either left untreated or blocked with anti-siglec-1 antibody (10 μg/ml) for 1 hr.
Saptarshi Roy (848212) +1 more
core +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
Modulation of Animal Gut Health by Milk Oligosaccharide
Animal Research and One Health, EarlyView.This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen +7 more
wiley +1 more source
CD24-Siglec interactions in inflammatory diseases
Frontiers in Immunology, 2023 CD24 is a small glycosylphosphatidylinositol (GPI)-anchored glycoprotein with broad expression in multiple cell types. Due to differential glycosylation, cell surface CD24 have been shown to interact with various receptors to mediate multiple ...
Yang Liu, Pan Zheng
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble +12 more
wiley +1 more source
Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers
Journal of the Formosan Medical Association, 2021 Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like lectins. All Siglecs have at least two domains including an extracellular domain with variable (V) and constant (C)-set immunoglobulin (Ig) regions, and a ...
Chia-Hsueh Lin +2 more
doaj +1 more source