Results 51 to 60 of about 11,185,234 (160)

Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung [PDF]

, 2014
Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently been shown to function as a negative regulator of ß2-integrin-dependent neutrophil recruitment to the lung following exposure to lipopolysaccharide (LPS).
Hegde, Vikas, Crocker, Paul R., Sarah J. McMillan, Ritu S. Sharma, Vikas Hegde, Paul R. Crocker, McMillan, Sarah J., Sharma, Ritu S., Richards, Hannah E., Hannah E. Richards   +9 more
core   +1 more source

Siglec-9⁺ CD56^dim cells exhibit lower cytotoxicity towards K562 cancer cells compared to Siglec-9^- CD56^dim.

, 2021
Cytotoxicity was assessed using NK degranulation and IFNγ production (E: T = 4:1). Total NK cells were gated on Siglec-9+ or Siglec-9- CD56dim NK cell subsets.
Han Xiao (373894), Opeyemi S. Adeniji (11682034), Ziyang Xu (1322553), Glen M. Chew (7122281), Costin Tomescu (606955), Ashley F. George (11682037), Mohamed Abdel-Mohsen (283492), Leticia Kuri-Cervantes (7382828), Chenfei Yu (1586326), Lishomwa C. Ndhlovu (7122293), David B. Weiner (9579320), Michelle Ho (6311882), Qin Liu (59805), Michael R. Betts (11682040), Nadia R. Roan (1320618), Kar Muthumani (504713), Cecilia Shikuma (22963)   +16 more
core   +1 more source

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

, 2017
Chronic inflammation plays a key role in both type 1 and type 2 diabetes. Cytokine and chemokine production within the islets in a diabetic milieu results in β-cell failure and diabetes progression.
G Dharmadhikari (21879041), NG Morgan (21853058), A Varki (21879047), K Stolz (21879044), K Maedler (21879056), M Hauke (20714723), S Kelm (21879053), E de Koning (21879050)   +7 more
core   +6 more sources

Long Noncoding RNA TUG1 Inhibits Tumor Progression through Regulating Siglec-15-Related Anti-Immune Activity in Hepatocellular Carcinoma

Journal of Immunology Research, 2022
Background. Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death, and its biology remains poorly understood, especially in regards to the immunosuppression induced by immune checkpoints, such as Siglec-15.
Yanyi Ren, Jiayi Lyu, Yaoguang Guo, Yuan Yao, Lin Hu   +4 more
doaj   +1 more source

Carbohydrate‐Directed Labeling Probes for UV‐Independent Chemoproteomic Profiling of Carbohydrate–Protein Interactions

Angewandte Chemie, EarlyView.
Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo, Wariya Nirachonkul, Nora Ross, Rahul M. Hedau, Zachary Clark, Michaella J. Rekowski, Michael P. Washburn, Mark P. Farrell   +7 more
wiley   +2 more sources

Additional file 2 of Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

, 2022
Additional file 2: FigureS2. Effect of Siglec-15 expressionrecovery on migration, invasion and autophagy of osteosarcoma cells. (a) Westernblots were used to detect the expression of EMT and autophagy-related proteinsin shSiglec-15-KHOS cells recovering ...
Chuanli Zhou (439175), Peng Yan (465646), Wenfang Chen (331226), Wei Guo (86150), Bin Yue (13111285), Lingling Sun (310915), Chongmin Ren (13111282), Yan Qu (682614), Keliang Song (13111279), Yang Gao (18005), Bingxin Zheng (4831539)   +10 more
core   +1 more source

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

Nature Medicine, 2019
Overexpression of the B7-H1 (PD-L1) molecule in the tumor microenvironment (TME) is a major immune evasion mechanism in some patients with cancer, and antibody blockade of the B7-H1/PD-1 interaction can normalize compromised immunity without excessive ...
Jun Wang, Jingwei Sun, Linda N. Liu, D. Flies, Xin-Xin Nie, Maria I Toki, Jian-Ping Zhang, Chang-xing Song, M. Zarr, Xu Zhou, Xue Han, K. Archer, Thomas O'Neill, R. Herbst, A. Boto, M. Sanmamed, S. Langermann, D. Rimm, Lie-Ping Chen   +18 more
semanticscholar   +1 more source

Die Rolle von Siglec-15 auf Osteoklasten und in Arthritis-Mausmodellen [PDF]

, 2022
Das Sialinsäure-bindende Immunglobulin-ähnliche Lektin 15 (Siglec-15) ist ein aktivierender Regulator der Osteoklastogenese und ist am physiologischen Knochenumbauprozess beteiligt. Diese Rolle von Siglec-15 konnte im Rahmen dieser Arbeit mit laborintern-
Korn, Marina
core   +1 more source

Image_1_Sialic Acid-Siglec-E Interactions During Pseudomonas aeruginosa Infection of Macrophages Interferes With Phagosome Maturation by Altering Intracellular Calcium Concentrations.TIF

, 2020
Pseudomonas aeruginosa (PA) is commonly associated with nosocomial and chronic infections of lungs. We have earlier demonstrated that an acidic sugar, sialic acid, is present in PA which is recognized and bound by sialic acid binding immunoglobulin type ...
Chitra Mandal (148111), Kaustuv Mukherjee (5277620), Biswajit Khatua (8504463)   +2 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source