Results 101 to 110 of about 11,185,234 (160)

Identification of therapeutic targets and prognostic biomarkers in the Siglec family of genes in tumor immune microenvironment of sarcoma

Scientific Reports
Sarcomas (SARC) are a highly heterogeneous cancer type that is prone to recurrence and metastasis. Numerous studies have confirmed that Siglecs are involved in immune signaling and play a key role in regulating immune responses in inflammatory diseases ...
Lili Qi, Kuiying Jiang, Fei-fei Zhao, Ping Ren, Ling Wang   +4 more
doaj   +1 more source

IL-4-STAT6-induced high Siglec-G/10 expression aggravates the severe immune suppressive tumor microenvironment and impedes the efficacy of immunotherapy in head and neck squamous cell carcinoma

Journal for ImmunoTherapy of Cancer
Background Immune checkpoint blockade therapy has shown limited efficacy in head and neck squamous cell carcinoma (HNSCC). Sialic acid binding immunoglobulin-like lectin (Siglec)-15 has been identified as a novel immune evasion biomarker, while the role ...
Ming Yan, Wenyi Yang, Zhaoyang Guo, Houyu Ju, Yusheng Lu, Yifan Fei, Yuanchen Yin, Guoxin Ren, Chaofeng Han, Jingzhou Hu   +9 more
doaj   +1 more source

Sialic acid cis-ligand dynamics modulate Siglec-7 and -9 function and affect Siglec-7/9 co-blockade to potentiate natural killer cell anti-tumor activity

OncoImmunology
The glyco-immune checkpoints Siglec-7 and Siglec-9 have received considerable interest as targets for cancer immunotherapy. How Siglec-7/9-sialic acid cis-interactions on immune cells influence trans-signaling induced by tumor cells and whether Siglec-7 ...
Jesper van Eck van der Sluijs, Anne H. C. Valk, Eline J. H. van Houtum, Esther D. Kers-Rebel, Maaike Looman, Willemijn Hobo, Anna E. Marneth, Harry Dolstra, Lune van den Boogaard, Christian Büll, Lenneke A. M. Cornelissen, Gosse J. Adema   +11 more
doaj   +1 more source

Siglec-1 RNAi reduces VCC volumes in HIV-1 NLUdel-infected MDMs.

, 2017
(A) MDMs were infected with VSV-G pseudotyped NLUdel. On the following day, MDMs were transfected with 60 nM scrambled, Siglec-1 or tetherin siRNA. At day 10 post-infection, MDMs were washed, fixed with 4% PFA and immunostained for p24 (green), Siglec-1 (
Sarah Takushi (3699919), Neal Beeman (3699922), Jason E. Hammonds (3699916), Lingmei Ding (324106), Jaang-Jiun Wang (253626), Gregory B. Melikyan (137795), Paul Spearman (156002), Ashwanth C. Francis (2836463)   +7 more
core   +1 more source

CA72-4 derived from synovial cells inhibits monosodium urate-induced macrophage M1 polarization by activating the TIGIT/SHP-1 axis through binding to Siglec-15

Autoimmunity
Excessive M1 polarization of macrophages is a key driver of inflammatory processes in gout, while the regulatory mechanisms involved remain unclear. Herein, the role of carbohydrate antigen 72-4 (CA72-4), derived from human synovial cells (HFLS), in ...
Honglei Hu, Xuefeng Bai, Lingyue Zhang, Hongmei Zhang, Qiang You, Shujuan Wang, Xueshan Bai   +6 more
doaj   +1 more source

Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition

Molecules
Aberrant glycosylation, especially sialylation, on cell surface is often associated with cancer progression and immunosuppression. Over-sialylation of stage-specific embryonic antigen-4 (SSEA-4) to generate disialylGb5 (DSGb5) was reported to trigger ...
Kuo-Shiang Liao, Yixuan Zhou, Cinya Chung, Chih-Chuan Kung, Chien-Tai Ren, Chung-Yi Wu, Yi-Wei Lou, Po-Kai Chuang, Balázs Imre, Yves S. Y. Hsieh, Chi-Huey Wong   +10 more
doaj   +1 more source

Expression and clinical significance of Siglec-15 in elderly patients with laryngeal squamous cell carcinoma

Zhongguo linchuang yanjiu
Objective To investigate the expression pattern of sialic acid-binding immunoglobulin-like lectin 15 (Siglec- 15) in laryngeal squamous cell carcinoma (LSCC) and its correlation with clinical characteristics.
DU Qilong, YANG Junrong, XU Li, JIANG Lihua, YE Wei, MAO Yuan, HUANG Wen   +6 more
doaj   +1 more source

Siglec-1 (cd169) expresszió vizsgálata monocyta alosztályokon gyulladásos myopathiákban

Absztrakt Háttér: Az idiopathias inflammatorikus myopathiák (IIM) szisztémás autoimmun betegségek, különböző klinikai megjelenési formákkal és patomechanizmusokkal. Ezen betegségekben az interferon útvonal az egyik fontos terápiás célpontok egyike.
Kun, Zsuzsanna Bella
core  

Expression of SIGLEC15 correlates with tumor immune infiltration, molecular subtypes, and breast cancer progression.

PLoS ONE
Breast cancer (BRCA) is among the most prevalent cancers and is responsible for numerous patient fatalities. Immunotherapy has emerged as a promising approach to cancer treatment.
Huan Lai, Yiyang Liu, Yan Gong, Chuanyu Zong, Wei Zeng, Honglei Chen   +5 more
doaj   +1 more source

Siglec 15 as a biomarker or a druggable molecule for non-small cell lung cancer. [PDF]

J Cancer Res Clin Oncol, 2023
Moreira RS, da Silva MM, de Melo Vasconcelos CF, da Silva TD, Cordeiro GG, Mattos-Jr LAR, da Rocha Pitta MG, de Melo Rêgo MJB, Pereira MC.   +8 more
europepmc   +1 more source