Results 211 to 220 of about 801,740 (256)
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Sigma 1 receptor: A new therapeutic target for pain
European Journal of Pharmacology, 2013Sigma 1 receptor (σ₁ receptor) is a unique ligand-regulated molecular chaperone located mainly in the endoplasmic reticulum and the plasma membrane. σ₁ receptor is activated under stress or pathological conditions and interacts with several neurotransmitter receptors and ion channels to modulate their function.
Luz Romero, Vela Jm, Manuel Merlos
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The sigma 1 receptor: A local media influencer
Cell Calcium, 2021The endoplasmic reticulum (ER) Ca2+ store contains many rapidly differentiable subdomains with specialized signaling properties. Recent work highlights how an integral ER membrane protein - the sigma 1 receptor (S1R) - nucleates local formation of cholesterol-rich ER subdomains.
Claudia M, Rohr, Jonathan S, Marchant
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Human Physiology, 2021
Part II of the review considers the literature data that pronounced cardioprotective activity is possessed by sigma-1 receptors (σ1Rs) and is associated with both membranotropic and chaperone activities. Activated σ1Rs exert a distinct antiarrhythmic/antifibrillatory effect, display anti-ischemia activity, and prevent left ventricular hypertrophy and ...
S. A. Kryzhanovskii +2 more
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Part II of the review considers the literature data that pronounced cardioprotective activity is possessed by sigma-1 receptors (σ1Rs) and is associated with both membranotropic and chaperone activities. Activated σ1Rs exert a distinct antiarrhythmic/antifibrillatory effect, display anti-ischemia activity, and prevent left ventricular hypertrophy and ...
S. A. Kryzhanovskii +2 more
openaire +1 more source
Sigma-1 receptor and inflammatory pain
Inflammation Research, 2015The sigma-1 receptor (Sig-1R) is a unique ligand-regulated molecular chaperone that interacts with several protein targets such as G protein-coupled receptors and ion channels to modulate their activity. Sig-1R is located in areas of the central and peripheral nervous system that are key to pain control.
Georgia, Gris +3 more
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2017
There is a critical need for new analgesics acting through new mechanisms of action, which could increase the efficacy respect to existing therapies and/or reduce their unwanted effects. Current preclinical evidence supports the modulatory role of the sigma-1 receptor (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout ...
Manuel, Merlos +4 more
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There is a critical need for new analgesics acting through new mechanisms of action, which could increase the efficacy respect to existing therapies and/or reduce their unwanted effects. Current preclinical evidence supports the modulatory role of the sigma-1 receptor (σ1R) in nociception, mainly based on the pain-attenuated phenotype of σ1R knockout ...
Manuel, Merlos +4 more
openaire +2 more sources
Focus on Molecules: the Sigma-1 Receptor
Experimental Eye Research, 2005The Sigma-1 receptor (accession number NP 005857) has no known homology with other receptors and in fact most closely resembles a C-8,7 sterol isomerase found in fungi (Hayashi and Su, 2003). The gene encodes a protein consisting of 223 amino acids with two transmembrane spanning domains and a typical argenine-argenine (R–R) endoplasmic reticulum (ER ...
Duncan, George, Wang, Lixin
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