Results 231 to 240 of about 801,740 (256)

Sigma-1 Receptor Ligands for CNS Cancer Treatment

CNS Drugs
The development of new and effective anticancer drugs remains a significant challenge owing to several factors, including the nonspecific nature of conventional therapies, the tendency of cancer cells to develop multidrug resistance, and the difficulty drugs face in crossing specialized barriers such as the blood-brain barrier (BBB) for cancers ...
Anchalee Prasansuklab, Stephen T. Safrany, Sirikalaya Brimson, James M. Brimson   +3 more
openaire   +2 more sources

Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases

2017
The sigma-1 (σ1) receptor has been associated with regulation of intracellular Ca2+ homeostasis, several cellular signaling pathways, and inter-organelle communication, in part through its chaperone activity. In vivo, agonists of the σ1 receptor enhance brain plasticity, with particularly well-described impact on learning and memory. Under pathological
Maurice, Tangui, Goguadze, Nino
openaire   +3 more sources

Sigma-1 receptor and the control of inflammation

2019
The endoplasmic reticulum resident protein sigma-1 receptor is druggable and controls inflammatory outcomes during acute inflammatory insults.
openaire   +1 more source

Sigma-1 Receptors Modulate NMDA Receptor Function

2013
The sigma-1 receptor (σ-1R) is an endoplasmic reticulum (ER) protein that modulates a number of ion channels. It is hypothesized that σ-1Rs activated with agonist translocate to the plasma membrane. The σ-1R potentiates N-methyl-D-aspartate Receptors (NMDARs), important constituents of synaptic plasticity.
openaire   +2 more sources

Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2

EMBO Molecular Medicine, 2022
, Wentian Zong, Xiaoan Wei
exaly  

Sigma-1 receptor: A potential target for the development of antidepressants

Neurochemistry International, 2022
Wei-Ku Zhang, Jie-Kun Xu, Hong-Mei Jia   +2 more
exaly  

The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer’s

Expert Opinion on Therapeutic Targets, 2021
Mani Iyer Prasanth, James Brimson, Tewin Tencomnao   +2 more
exaly  

Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo

AAPS Journal, 2020
Tamara KING, Christopher R Mccurdy, Jay Mclaughlin   +2 more
exaly  

Sigma‐2 Receptor Ligands and Their Perspectives in Cancer Diagnosis and Therapy

Medicinal Research Reviews, 2014
Yun-Sheng Huang
exaly  

Potential applications for sigma receptor ligands in cancer diagnosis and therapy

Biochimica Et Biophysica Acta - Biomembranes, 2015
Philip Elsinga, Aren Van Waarde, Rudi Dierckx   +2 more
exaly